Details of Disease

General Information of Disease (ID: DISF94A2)

Disease Name	Tularemia
Synonyms	Pahvant Valley plague; Ohara disease; rabbit fever; lemming fever; Francisella tularensis infection; Deerfly fever; Yatobyo (Japan); Francisella tularensis disease or disorder; Francisella tularensis infectious disease; Francisella tularensis caused disease or disorder
Disease Class	1B94: Tularaemia
Definition	Tularemia is an infection caused by the bacterium Francisella tularensis. It is more common in rodents and rabbits but has been found in other animals including domestic cats, sheep, birds, and hamsters. Humans can become infected in several different ways: by handling infected animals, through tick or deer fly bites, by drinking contaminated water, or by inhaling contaminated dust or aerosols. Person-to-person transmission has not been reported. The type of tularemia and the particular signs and symptoms vary depending on how the bacteria enter the body. However, fever is seen in most cases. Though tularemia can be life-threatening, most infections can be treated with antibiotics.
Disease Hierarchy	DISGFCIX: Vector-borne disease DIS8ZVFW: Primary bacterial infectious disease DISEM33Q: Infectious disease DISF94A2: Tularemia
ICD Code	ICD-11 ICD-11: 1B94 Expand ICD-11 '1B94 Expand ICD-10 'A21; 'A21.1; 'A21.2; 'A21.3; 'A21.7; 'A21.8; 'A21.9
Disease Identifiers	MONDO ID MONDO_0018077 MESH ID D014406 UMLS CUI C0041351 MedGen ID 22520 Orphanet ID 3392 SNOMED CT ID 19265001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Doxycycline	DM7ICNU	Approved	Small molecular drug	[1]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[2]
Minocycline	DMVN5OH	Approved	Small molecular drug	[3]
Streptomycin	DME1LQN	Approved	Small molecular drug	[4]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
DVC-LVS	DMLGFUD	Phase 2	NA	[5]
Tularemia vaccine	DMZ6PBJ	Phase 1	NA	[5]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Lm Ft	DMKGHKG	Investigative	NA	[6]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
MSRB2	DEMQOF7	Strong	Biomarker	[7]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GPR162	OTK4LT3K	Strong	Genetic Variation	[8]
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References

1	Doxycycline FDA Label
2	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
3	Minocycline FDA Label
4	Streptomycin FDA Label
5	ClinicalTrials.gov (NCT01150695) Phase II Tularemia Vaccine Comparison. U.S. National Institutes of Health.
6	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
7	Contribution of methionine sulfoxide reductase B (MsrB) to Francisella tularensis infection in mice.FEMS Microbiol Lett. 2017 Jan;364(2):fnw260. doi: 10.1093/femsle/fnw260. Epub 2016 Nov 13.
8	Phylogenetic Analysis of Francisella tularensis Group A.II Isolates from 5 Patients with Tularemia, Arizona, USA, 2015-2017.Emerg Infect Dis. 2019 May;25(5):944-946. doi: 10.3201/eid2505.180363.