Details of Disease

General Information of Disease (ID: DISGOZ4P)

Disease Name	Conjunctivitis
Synonyms	Madras eye; pink eye; inflammation of conjunctiva; conjunctivitis (disease); conjunctivitis; conjunctiva inflammation
Disease Class	9A60: Conjunctiva disorder
Definition	Inflammation of the conjunctiva of the eye.
Disease Hierarchy	DISWD40R: Disease DISPTOTB: Conjunctival disorder DIS184KT: Skin inflammation DISGOZ4P: Conjunctivitis
ICD Code	ICD-11 ICD-11: 9A60 ICD-9 ICD-9: 372 Expand ICD-11 '9A60 Expand ICD-10 'H10; 'H10.2; 'H10.3; 'H10.4; 'H10.8; 'H10.9; 'H13.1 Expand ICD-9 372
Disease Identifiers	MONDO ID MONDO_0003799 MESH ID D003231 UMLS CUI C0009763 MedGen ID 1093 HPO ID HP:0000509 SNOMED CT ID 9826008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Natamycin	DMFEHXD	Approved	Small molecular drug	[1]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Pazufloxacin	DMHXTAQ	Phase 3	Small molecular drug	[2]
Cobalt chelate complex CTC-96 dermatological	DMWK4CZ	Phase 2	NA	[3]
PVP-ILH	DMISPKS	Phase 2	NA	[4]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
DE-081	DM3AVO1	Discontinued in Phase 2	Small molecular drug	[5]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 4 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
NVC-638	DMTSJIF	Investigative	NA	[6]
NVC-704	DMSX0GM	Investigative	NA	[6]
NVC-727	DMI6Y5P	Investigative	NA	[6]
ZK-209614	DMKYJR3	Investigative	NA	[6]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PTAFR	TTQL5VC	Strong	Biomarker	[7]
------------------------------------------------------------------------------------

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
HM13	OTGEO1LP	Limited	Biomarker	[8]
IMMP1L	OTA6LOLR	Limited	Biomarker	[8]
IMPA1	OTBUVW1Z	Limited	Biomarker	[8]
PLD3	OTL07SP2	Strong	Genetic Variation	[9]
------------------------------------------------------------------------------------

References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 050514.
2	ClinicalTrials.gov (NCT03696342) Efficacy of the Ophthalmic Pazufloxacin 0.6% for Bacterial Conjunctivitis, Compared to Gatifloxacin 0.3%. (PRO-157). U.S. National Institutes of Health.
3	Clinical pipeline report, company report or official report of Avarx.
4	Polyvinyl pyrrolidone-iodine liposome hydrogel improves epithelialization by combining moisture and antisepis. A new concept in wound therapy. Wound Repair Regen. 2001 Mar-Apr;9(2):116-22.
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000113)
6	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
7	Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis.Mol Vis. 2005 Feb 9;11:114-23.
8	Analysis of IMP-1 type metallo--lactamase-producing Acinetobacter radioresistens isolated from companion animals.J Infect Chemother. 2017 Sep;23(9):655-657. doi: 10.1016/j.jiac.2017.03.011. Epub 2017 Apr 10.
9	Genome types of adenovirus types 19 and 37 isolated from patients with conjunctivitis in Hiroshima City.J Med Virol. 1988 Sep;26(1):15-22. doi: 10.1002/jmv.1890260104.