Details of Disease

Disease Name

Histoplasmosis

darling disease; Histoplasma caused disease or disorder; Histoplasma infectious disease; Histoplasma disease or disorder

Definition

A disease caused by the fungus Histoplasma capsulatum. It primarily affects the lungs but can also occur as a disseminated disease that affects additional organs. The acute respiratory disease has symptoms similar to those of a cold or flu and it usually resolves without treatment in healthy individuals. The disseminated form is generally fatal if untreated.

Disease Hierarchy

DISIP7GM: Primary systemic mycosis

DISEM33Q: Infectious disease

DISGTF4W: Histoplasmosis

Disease Identifiers

MONDO ID

MONDO_0018312

MESH ID

D006660

UMLS CUI

C0019655

MedGen ID

42468

HPO ID

HP:0032256

Orphanet ID

390

SNOMED CT ID

12962009

General Information of Disease (ID: DISGTF4W)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Itraconazole	DMCR1MV	Approved	Small molecular drug	[2]
Ketoconazole	DMPZI3Q	Approved	Small molecular drug	[3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ATP6V1A	TTL2PXZ	Strong	Biomarker	[4]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CIAO3	OT0V91PK	Strong	Biomarker	[5]
RPS4X	OTIH80EK	Strong	Biomarker	[6]
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References

1	Amphotericin B FDA Label
2	Itraconazole FDA Label
3	Ketoconazole FDA Label
4	The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis.Mol Microbiol. 2008 Oct;70(1):127-39. doi: 10.1111/j.1365-2958.2008.06395.x. Epub 2008 Aug 11.
5	PRN Ranibizumab in the Treatment of Choroidal Neovascularization Secondary to Ocular Histoplasmosis.Ophthalmic Surg Lasers Imaging Retina. 2018 Jan 1;49(1):20-26. doi: 10.3928/23258160-20171215-03.
6	Development of specific sequence-characterized amplified region markers for detecting Histoplasma capsulatum in clinical and environmental samples.J Clin Microbiol. 2012 Mar;50(3):673-9. doi: 10.1128/JCM.05271-11. Epub 2011 Dec 21.