Details of Disease | DrugMAP

General Information of Disease (ID: DISGV2SE)

Disease Name	Uterine disorder
Synonyms	uterus disease or disorder; uterus disease; uterine disorder; uterine disease; disorder of uterus; disease or disorder of uterus; disease of uterus
Definition	A non-neoplastic or neoplastic disorder that affects the uterine corpus or the cervix. Representative examples of non-neoplastic disorders include endometritis and cervicitis. Representative examples of neoplastic disorders include endometrial carcinoma, carcinosarcoma, and cervical carcinoma.
Disease Hierarchy	DISWD40R: Disease DISXEPZF: Gynecological disease DISGV2SE: Uterine disorder
Disease Identifiers	MONDO ID MONDO_0002654 MESH ID D014591 UMLS CUI C0042131 MedGen ID 22590 SNOMED CT ID 12337004

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
HSD17B1	TTIWB6L	Strong	Genetic Variation	[1]
CGA	TTFC29G	Definitive	Therapeutic	[2]
------------------------------------------------------------------------------------

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
KLF11	OTKVQDJD	Strong	Altered Expression	[3]
------------------------------------------------------------------------------------

References

1	Association between HSD17B1 rs605059 polymorphisms and the risk of uterine diseases: a systemic review and meta-analysis.Int J Clin Exp Pathol. 2015 Jun 1;8(6):6012-8. eCollection 2015.
2	The involvement of hypophyseal-gonadal and hypophyseal-adrenal axes in arsenic-mediated ovarian and uterine toxicity: modulation by hCG.J Biochem Mol Toxicol. 2010 Jan-Feb;24(1):29-41. doi: 10.1002/jbt.20309.
3	KLF10 Mediated Epigenetic Dysregulation of Epithelial CD40/CD154 Promotes Endometriosis.Biol Reprod. 2016 Sep;95(3):62. doi: 10.1095/biolreprod.116.140764. Epub 2016 Aug 3.