Details of Disease

General Information of Disease (ID: DISGYLY2)

Disease Name Hypoactive sexual desire disorder
Synonyms lack or loss of sexual desire
Definition
A disorder characterized by a recurrent or persistent lack of desire for sexual activity. The lack of sexual desire is not attributable to another psychiatric disorder or to the physiological effects of substance use or a general medical condition.
Disease Hierarchy
DISGQK8E: Psychosexual disorder
DISGYLY2: Hypoactive sexual desire disorder
Disease Identifiers
MONDO ID
MONDO_0001821
MESH ID
D020018
UMLS CUI
C0020594
MedGen ID
43792
SNOMED CT ID
270903007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Flibanserin DM70DTN Approved Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 6 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
GRIA1 TTVPQTF Strong Biomarker [2]
GRIA3 TT82EZV Strong Biomarker [2]
GRIK2 TT0K5RG Strong Biomarker [2]
PRL TTJ2TSA Strong Biomarker [3]
CYP17A1 TTRA5BZ Definitive Biomarker [4]
CYP2D6 TTVG215 Definitive Biomarker [5]
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⏷ Show the Full List of 6 DTT(s)
This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
FEZF1 OTRX4NOT Strong Biomarker [6]
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References

1 Flibanserin FDA Label
2 Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. Neuropsychopharmacology. 2009 Jun;34(7):1819-28. doi: 10.1038/npp.2009.4. Epub 2009 Mar 18.
3 Testosterone replacement-induced hyperprolactinaemia: case report and review of the literature.Ann Clin Biochem. 2005 Mar;42(Pt 2):153-9. doi: 10.1258/0004563053492784.
4 Haploinsufficiency of cytochrome P450 17alpha-hydroxylase/17,20 lyase (CYP17) causes infertility in male mice.Mol Endocrinol. 2005 Sep;19(9):2380-9. doi: 10.1210/me.2004-0418. Epub 2005 May 12.
5 Links among paroxetine-induced sexual dysfunctions, gender, and CYP2D6 activity.J Sex Marital Ther. 2007 Jul-Sep;33(4):343-55. doi: 10.1080/00926230701385589.
6 Fezf1 is a novel regulator of female sex behavior in mice.Horm Behav. 2018 Jan;97:94-101. doi: 10.1016/j.yhbeh.2017.10.010. Epub 2017 Nov 14.