Details of Disease

General Information of Disease (ID: DISIZ0VJ)

• Disease Name: Invasive pulmonary aspergillosis
• Disease Class: 1F20: Aspergillosis
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISIZ0VJ: Invasive pulmonary aspergillosis
• ICD Code:
  ICD-11: ICD-11: 1F20.0
  ICD-10: ICD-10: B44.0
  Expand ICD-11: '1F20.0
  Expand ICD-10: 'B44.0
• Disease Identifiers:
  MONDO ID: MONDO_0005657
  MESH ID: D001228
  UMLS CUI: C0004030
  MedGen ID: 13939
  HPO ID: HP:0020103
  Orphanet ID: 1163
  SNOMED CT ID: 65553006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ASP2397	DMQ5FEC	Phase 2	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BACE1	TTJUNZF	Strong	Biomarker	[2]
CD209	TTBXIM9	Strong	Biomarker	[3]
IDO2	TTALN9W	Strong	Genetic Variation	[4]
TICAM1	TT2GQT6	Strong	Biomarker	[5]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CLEC7A	OTRTBH27	Limited	Biomarker	[6]
ICAM3	OTTZ5A5D	Strong	Biomarker	[7]
PTX3	OTPXHRKU	Strong	Biomarker	[8]
TRIM69	OTTEGTRD	Strong	Biomarker	[5]

References

• [1] ClinicalTrials.gov (NCT03327727) VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis (IA) in Adults. U.S. National Institutes of Health.
• [2] Functional selection of protease inhibitory antibodies.Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16314-16319. doi: 10.1073/pnas.1903330116. Epub 2019 Jul 30.
• [3] Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages.J Immunol. 2004 Nov 1;173(9):5635-43. doi: 10.4049/jimmunol.173.9.5635.
• [4] Genetic Polymorphisms Affecting IDO1 or IDO2 Activity Differently Associate With Aspergillosis in Humans.Front Immunol. 2019 May 7;10:890. doi: 10.3389/fimmu.2019.00890. eCollection 2019.
• [5] PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis.J Immunol. 2014 Sep 1;193(5):2340-8. doi: 10.4049/jimmunol.1400814. Epub 2014 Jul 21.
• [6] Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity.Blood. 2010 Dec 9;116(24):5394-402. doi: 10.1182/blood-2010-04-279307. Epub 2010 Aug 31.
• [7] Overexpression of Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin in Dendritic Cells Protecting against Aspergillosis.Chin Med J (Engl). 2018 Nov 5;131(21):2575-2582. doi: 10.4103/0366-6999.244103.
• [8] Pentraxin 3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with pulmonary aspergillosis.Clin Microbiol Infect. 2019 Apr;25(4):504-510. doi: 10.1016/j.cmi.2018.06.015. Epub 2018 Jun 28.