Details of Disease

General Information of Disease (ID: DISJ17C5)

Disease Name Thymus lymphoma
Synonyms thymus lymphoma; thymic lymphoma; primary thymic lymphoma; lymphoma of thymus; lymphoma of the Thymus; lymphoma of Thymus; Thymus lymphoma
Definition A lymphoma that arises from the thymus. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma.
Disease Hierarchy
DIS0TBWN: Thymus cancer
:
DISN6V4S: Lymphoma
DISJ17C5: Thymus lymphoma
Disease Identifiers
MONDO ID
MONDO_0000951
UMLS CUI
C1336745
MedGen ID
277818

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
DOT1L TTSZ8T1 Strong Posttranslational Modification [1]
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This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC6A6 DTHWCVA moderate Biomarker [2]
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This Disease Is Related to 6 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CBFA2T2 OTNOIB23 Strong Biomarker [3]
IL2RG OTRZ3OMY Strong Biomarker [4]
PPP1R12C OT9Q86JO Strong Biomarker [3]
PPP1R13B OTC88VQO Strong Biomarker [3]
RPL22 OTVCN8K0 Strong Biomarker [5]
SETD4 OTBMCZQA Strong Biomarker [6]
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⏷ Show the Full List of 6 DOT(s)

References

1 Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.EMBO J. 2019 Jul 15;38(14):e101564. doi: 10.15252/embj.2019101564. Epub 2019 Jun 17.
2 Targeting Taurine Transporter (TauT) for Cancer Immunotherapy of p53 Mutation Mediated Cancers - Molecular Basis and Preclinical Implication.Adv Exp Med Biol. 2019;1155:543-553. doi: 10.1007/978-981-13-8023-5_50.
3 Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).Leukemia. 2002 May;16(5):894-901. doi: 10.1038/sj.leu.2402484.
4 Histopathological characteristics of human non-tumor thyroid tissues in a long-term model of adenomatous goiter xenografts in the NOD/Shi-scid, IL-2R(null) mouse.Exp Toxicol Pathol. 2014 Jul;66(4):203-9. doi: 10.1016/j.etp.2014.01.006. Epub 2014 Feb 28.
5 Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.Blood. 2012 Nov 1;120(18):3764-73. doi: 10.1182/blood-2012-03-415349. Epub 2012 Sep 13.
6 Loss of Setd4 delays radiation-induced thymic lymphoma in mice.DNA Repair (Amst). 2020 Feb;86:102754. doi: 10.1016/j.dnarep.2019.102754. Epub 2019 Nov 25.