Details of Disease

General Information of Disease (ID: DISJ3RYM)

Disease Name Thyroid cancer, nonmedullary, 2
Synonyms
NMTC2; thyroid cancer, follicular; thyroid carcinoma, follicular; FTC; thyroid cancer, nonmedullary, 2; thyroid carcinoma, follicular, autosomal dominant, somatic mutation; thyroid cancer, nonmedullary, 2, autosomal dominant, somatic mutation; thyroid cancer, nonmedullary, type 2; thyroid carcinoma, follicular, somatic
Disease Hierarchy
DIS4NUGC: Familial papillary or follicular thyroid carcinoma
DISFK2QT: Thyroid gland follicular carcinoma
DISJ3RYM: Thyroid cancer, nonmedullary, 2
Disease Identifiers
MONDO ID
MONDO_0008566
UMLS CUI
C4225426
OMIM ID
188470
MedGen ID
904175

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
HRAS TT28ZON Limited Genetic Variation [1]
NRAS TTW2R9X Limited Genetic Variation [1]
PTEN TTXJ3W7 Strong Biomarker [2]
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This Disease Is Related to 2 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
MINPP1 DE5Q1SP No Known Unknown [3]
MINPP1 DE5Q1SP Strong Genetic Variation [4]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
MINPP1 OTNYPPCC No Known Unknown [3]
SRGAP1 OTL89HGW No Known Autosomal dominant [5]
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References

1 RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.J Clin Endocrinol Metab. 2003 May;88(5):2318-26. doi: 10.1210/jc.2002-021907.
2 Multiple hamartoma syndrome (Cowden's disease).Arch Dermatol. 1972 Nov;106(5):682-90.
3 Exome sequencing of a large family identifies potential candidate genes contributing risk to bipolar disorder. Gene. 2018 Mar 1;645:119-123. doi: 10.1016/j.gene.2017.12.025. Epub 2017 Dec 14.
4 Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas.J Clin Endocrinol Metab. 2001 Apr;86(4):1801-5. doi: 10.1210/jcem.86.4.7419.
5 SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility. J Clin Endocrinol Metab. 2013 May;98(5):E973-80. doi: 10.1210/jc.2012-3823. Epub 2013 Mar 28.