Details of Disease

General Information of Disease (ID: DISK7GAB)

• Disease Name: Kidney disease
• Synonyms: kidney disease; disease of kidney
• Disease Class: GC2Z: Urinary system disease
• Definition: Any disease in which the causes of the disease is a perturbation of the kidney leading to its dysfunction.
• Disease Hierarchy:
  DISWD40R: Disease
  DISXWP4P: Nephropathy
  DISK7GAB: Kidney disease
• ICD Code:
  ICD-11: ICD-11: GC2Z
  Expand ICD-10: D50,D51,D52,D53,D54,D55,D56,D57,D58,D59,D60,D61,D62,D63,D64,N00,N01,N02,N03,N04,N05,N06,N07,N08,N09,N10,N11,N12,N13,N14,N15,N16,N17,N18,N19,N20,N21,N22,N23,N24,N25,N26,N27,N28,N29
  Expand ICD-9: 2.80E+47
• Disease Identifiers:
  MONDO ID: MONDO_0001343
  UMLS CUI: C0341677
  MedGen ID: 574572

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Aminohippurate sodium	DM0ODBG	Approved	Small molecular drug	[1]
Cinacalcet	DMCX0K3	Approved	Small molecular drug	[2]
Icodextrin	DM648X9	Approved	Small molecular drug	[1]
Tenapanor	DMCOZJY	Approved	Small molecular drug	[3]
Voclosporin	DMWIJTN	Approved	Small molecular drug	[4]
BMP-7 bone morphogenetic protein	DMI2UFO	Phase 4	NA	[5]

This Disease is Treated as An Indication in 7 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CTAP101	DMLCBHW	Preregistration	NA	[6]
FG-4592	DM4XSQ2	Phase 3	Small molecular drug	[7]
62Cu-ETS	DMT5SSZ	Phase 2	NA	[8]
FG-2216	DM7RYL4	Phase 2	NA	[9]
HD-003	DMRQGMZ	Phase 2	NA	[10]
KD020	DMZ416B	Phase 1/2	NA	[11]
LEO-27847	DM38SI1	Phase 1	NA	[12]

This Disease is Treated as An Indication in 2 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
RG7641	DMP8PQW	Discontinued in Phase 1	NA	[13]
A-68828	DMX2UTO	Terminated	NA	[14]

This Disease is Treated as An Indication in 5 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AA-204	DMBGTX9	Investigative	NA	[15]
CT-100	DMFBE2B	Investigative	Small molecular drug	[16]
ETR-001	DMWIPML	Investigative	NA	[16]
INDUS-815B	DMBOQ6M	Investigative	NA	[17]
Recombinant human CFH protein	DMMGR86	Investigative	NA	[16]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3308).
• [3] ClinicalTrials.gov (NCT01764854) Pharmacodynamic Study of AZD1722 in End-stage Renal Disease Patients on Hemodialysis. U.S. National Institutes of Health.
• [4] Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4886).
• [6] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025617)
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8454).
• [8] ClinicalTrials.gov (NCT00714142) Renal Blood Flow Measurement With Positron Emission Tomography (PET). U.S. National Institutes of Health.
• [9] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018242)
• [10] ClinicalTrials.gov (NCT02378194) Change From Baseline to Chronic Kidney Disease Patient Before and After Administration Drug. U.S. National Institutes of Health.
• [11] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020855)
• [12] ClinicalTrials.gov (NCT01007383) LEO 27847 - A Study in Healthy Male Subjects. U.S. National Institutes of Health.
• [13] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039781)
• [14] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003432)
• [15] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1794).
• [16] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [17] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1489).