Details of Disease

General Information of Disease (ID: DISLBTU2)

Disease Name	Cryptosporidium infection
Synonyms	Cryptosporidioses; Cryptosporidium infection; Cryptosporidium disease or disorder; infection by Cryptosporidium; intestinal cryptosporidiosis; Cryptosporidium infectious disease; Cryptosporidium caused disease or disorder; Cryptosporidial gastroenteritis
Disease Class	1A32: Cryptosporidiosis
Definition	Intestinal infection with organisms of the genus Cryptosporidium. It occurs in both animals and humans. Symptoms include severe diarrhea.
Disease Hierarchy	DISVU41B: Coccidiosis DIS1DL0Z: Parasitic intestinal disorder DISEM33Q: Infectious disease DISLBTU2: Cryptosporidium infection
ICD Code	ICD-11 ICD-11: 1A32 ICD-10 ICD-10: A07.2 Expand ICD-11 '1A32 Expand ICD-10 'A07.2
Disease Identifiers	MONDO ID MONDO_0015474 MESH ID D003457 UMLS CUI C0010418 MedGen ID 41362 Orphanet ID 1549 SNOMED CT ID 240370009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Nitazoxanide	DMOWLVG	Approved	Small molecular drug	[1]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CryptoGAM	DMZJZGK	Discontinued in Phase 2	NA	[2]
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This Disease is Treated as An Indication in 2 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Recombinant mab-biocide fusion proteins	DMG5ATW	Investigative	NA	[3]
RM-6427	DM87Z3Y	Investigative	NA	[4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CD7	TTP6B8O	Disputed	Biomarker	[5]
RARG	TT1Q3IE	Definitive	Biomarker	[6]
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This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
OXA1L	OTS0BFRD	Strong	Biomarker	[7]
BRAP	OTB7BAFQ	Definitive	Biomarker	[8]
CEMP1	OTUEH5X5	Definitive	Altered Expression	[9]
IMPA1	OTBUVW1Z	Definitive	Biomarker	[8]
KARS1	OT0EU4SV	Definitive	Biomarker	[10]
PTGES3	OTPPQWI0	Definitive	Genetic Variation	[11]
STK24	OTGUHOIL	Definitive	Genetic Variation	[12]
TMED10	OTUXSHH7	Definitive	Genetic Variation	[11]
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⏷ Show the Full List of 8 DOT(s)

References

1	Nitazoxanide FDA Label
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007103)
3	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797).
5	Molecular cloning and expression of a gene encoding Cryptosporidium parvum glycoproteins gp40 and gp15.Infect Immun. 2000 Jul;68(7):4108-16. doi: 10.1128/IAI.68.7.4108-4116.2000.
6	Self-binding peptides: Binding-upon-folding versus folding-upon-binding.J Theor Biol. 2019 May 21;469:25-34. doi: 10.1016/j.jtbi.2019.02.014. Epub 2019 Feb 23.
7	Decrypting the oscillating nature of the 4'-phosphopantetheine arm in acyl carrier protein AcpM of Mycobacteriumtuberculosis.FEBS Lett. 2019 Mar;593(6):622-633. doi: 10.1002/1873-3468.13339. Epub 2019 Mar 8.
8	Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis.Antimicrob Agents Chemother. 2014;58(3):1603-14. doi: 10.1128/AAC.02075-13. Epub 2013 Dec 23.
9	Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study.Clin Infect Dis. 2020 Jan 2;70(2):323-326. doi: 10.1093/cid/ciz430.
10	Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20.
11	Systemic antibody responses to the immunodominant p23 antigen and p23 polymorphisms in children with cryptosporidiosis in Bangladesh.Am J Trop Med Hyg. 2012 Feb;86(2):214-22. doi: 10.4269/ajtmh.2012.11-0273.
12	Molecular analysis of 311 Cryptococcus neoformans isolates from a 30-month ECMM survey of cryptococcosis in Europe.FEMS Yeast Res. 2006 Jun;6(4):614-9. doi: 10.1111/j.1567-1364.2006.00081.x.