Details of Disease

General Information of Disease (ID: DISMSQ11)

Disease Name Lymphoplasmacytic lymphoma
Synonyms
lymphoplasmacytoid lymphoma; lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia); lymphoplasmacytic lymphoma; lymphoma, plasmacytic; lymphoma, lymphoplasmacytic, malignant; Immunocytoma, lymphoplasmacytic type
Definition A clonal neoplasm of small B-lymphocytes, lymphoplasmacytoid cells, and plasma cells involving the bone marrow, lymph nodes, and the spleen. The majority of patients have a serum IgM paraprotein.
Disease Hierarchy
DISVY326: B-cell neoplasm
DISMSQ11: Lymphoplasmacytic lymphoma
Disease Identifiers
MONDO ID
MONDO_0000432
UMLS CUI
C0334633
MedGen ID
473052
SNOMED CT ID
19340000

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 4 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
PAX5 TTA4REJ Limited Genetic Variation [1]
LPL TTOF3WZ Strong Genetic Variation [2]
MALT1 TTCI81G Strong Genetic Variation [1]
ZAP70 TTUMHT8 Strong Altered Expression [3]
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This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC35B2 DT81RKJ Limited Biomarker [4]
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This Disease Is Related to 5 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACSBG1 OTM040MW Limited Biomarker [5]
EXOC2 OT5QG1WG Limited Genetic Variation [6]
IBTK OTB2GM4G Limited Biomarker [7]
RAPH1 OTMQXW7S Limited Biomarker [5]
BCL9 OTRBIPR4 moderate Altered Expression [8]
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References

1 Fluorescence immunophenotypic and interphase cytogenetic characterization of nodal lymphoplasmacytic lymphoma.Am J Surg Pathol. 2008 Nov;32(11):1643-53. doi: 10.1097/PAS.0b013e3181758806.
2 Outcomes of bendamustine- or cyclophosphamide-based first-line chemotherapy in older patients with indolent B-cell lymphoma.Am J Hematol. 2020 Apr;95(4):354-361. doi: 10.1002/ajh.25707. Epub 2020 Jan 2.
3 Distribution and ZAP-70 expression of WHO lymphoma categories in Shanxi, China: a review of 447 cases using a tissue microarray technique.Appl Immunohistochem Mol Morphol. 2005 Dec;13(4):323-32. doi: 10.1097/01.pai.0000176161.38402.b2.
4 CD5+ true SLL/CLL with plasmacytic differentiation and an unusual 1p36 translocation: case report and review of the literature.Leuk Lymphoma. 2000 Nov;39(5-6):625-32. doi: 10.3109/10428190009113393.
5 CD13 expression in B cell malignancies is a hallmark of plasmacytic differentiation.Br J Haematol. 2019 Feb;184(4):625-633. doi: 10.1111/bjh.15584. Epub 2018 Sep 10.
6 Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenstrm macroglobulinemia.Nat Commun. 2018 Oct 10;9(1):4182. doi: 10.1038/s41467-018-06541-2.
7 Ibrutinib increases the risk of hypertension and atrial fibrillation: Systematic review and meta-analysis.PLoS One. 2019 Feb 20;14(2):e0211228. doi: 10.1371/journal.pone.0211228. eCollection 2019.
8 The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.Nat Med. 2015 Jun;21(6):572-80. doi: 10.1038/nm.3867. Epub 2015 May 25.