Details of Disease

General Information of Disease (ID: DISPFUV2)

Disease Name	Bile duct disease
Synonyms	disorder of bile duct; disease or disorder of bile duct; disease of bile duct; bile duct disorder; bile duct disease or disorder; bile duct disease
Disease Class	LB20: Gallbladder/bile ducts/liver structural developmental anomaly
Definition	A disease involving the bile duct.
Disease Hierarchy	DISWD40R: Disease DISNBDRC: Biliary tract disorder DISPFUV2: Bile duct disease
ICD Code	ICD-11 ICD-11: LB20
Disease Identifiers	MONDO ID MONDO_0002887 MESH ID D001649 UMLS CUI C0005395 MedGen ID 2240 SNOMED CT ID 118926004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Iodoxamate Meglumine	DMZBZAC	Approved	NA	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FECH	TTQ6VF4	Strong	Biomarker	[2]
GPBAR1	TTSDVTR	Strong	Biomarker	[3]
ENPP3	TTD4TKP	Definitive	Biomarker	[4]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MAGEE1	OTOQQO2X	Strong	Biomarker	[5]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria.Gastroenterology. 1999 Sep;117(3):696-705. doi: 10.1016/s0016-5085(99)70464-6.
3	TGR5 sequence variation in primary sclerosing cholangitis.Dig Dis. 2011;29(1):78-84. doi: 10.1159/000324138. Epub 2011 Jun 17.
4	Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases.Cancer Lett. 2004 Apr 30;207(2):139-47. doi: 10.1016/j.canlet.2003.11.002.
5	Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury.Front Genet. 2018 Nov 20;9:527. doi: 10.3389/fgene.2018.00527. eCollection 2018.