Details of Disease

General Information of Disease (ID: DISQ5G6G)

• Disease Name: Hemorrhoids
• Synonyms: hemorrhoidal disease; hemorrhoid; Hemorrhoids; Haemorrhoids
• Disease Class: DB60: Haemorrhoids
• Definition: Dilated veins in the anal canal.
• Disease Hierarchy:
  DISSWEZH: Pelvic varices
  DISQ5G6G: Hemorrhoids
• ICD Code:
  ICD-11: ICD-11: DB60
  ICD-10: ICD-10: K64.8
  Expand ICD-11: 'DB60
  Expand ICD-10: 'K64.8
• Disease Identifiers:
  MONDO ID: MONDO_0004872
  MESH ID: D006484
  UMLS CUI: C0019112
  MedGen ID: 5507
  HPO ID: HP:0032551
  SNOMED CT ID: 70153002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Diosmin	DM29M30	Approved	Small molecular drug	[1]
Morrhuate sodium	DMX5B7G	Approved	NA	[1]
OC-108	DMFH3QR	Approved	NA	[1]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Streptokinase rectal suppository	DMVLKDX	Phase 3	NA	[2]

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Iferanserin-Ventrus	DMDEL2W	Discontinued in Phase 3	NA	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
HAL	TTXQOZW	Strong	Genetic Variation	[4]
PON1	TT9LX82	Strong	Biomarker	[5]
SLC2A9	TTIF3GB	Strong	Genetic Variation	[6]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
DIO3	DET89OV	Strong	Altered Expression	[7]

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AP5M1	OTDLWEBL	Strong	Biomarker	[8]
MARK1	OTP7KL47	Strong	Biomarker	[8]
PPP4C	OT4B0TNV	Strong	Genetic Variation	[9]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Recombinant streptokinase vs phenylephrine-based suppositories in acute hemorrhoids, randomized, controlled trial (THERESA-3). World J Gastroenterol. 2014 Feb 14;20(6):1594-601.
• [3] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014343)
• [4] Assessment of haemorrhoidal artery network using Doppler-guided haemorrhoidal artery ligation for haemorrhoids and pathogenesis implications.ANZ J Surg. 2019 Jul;89(7-8):E288-E291. doi: 10.1111/ans.15143. Epub 2019 Jul 1.
• [5] Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross-sectional study of a Greek rural population professionally exposed to pesticides.Toxicol Lett. 2009 Apr 10;186(1):66-72. doi: 10.1016/j.toxlet.2008.10.018. Epub 2008 Oct 28.
• [6] Biological findings from the PheWAS catalog: focus on connective tissue-related disorders (pelvic floor dysfunction, abdominal hernia, varicose veins and hemorrhoids).Hum Genet. 2016 Jul;135(7):779-95. doi: 10.1007/s00439-016-1672-8. Epub 2016 Apr 28.
• [7] miR-412-5p targets Xpo1 to regulate angiogenesis in hemorrhoid tissue.Gene. 2019 Jul 15;705:167-176. doi: 10.1016/j.gene.2019.04.058. Epub 2019 Apr 23.
• [8] Correction: Altered mental status and an acid-base disturbance.Cleve Clin J Med. 2017 Mar;84(3):214.
• [9] Implementation of a New High-Volume Circular Stapler in Stapled Anopexy for Hemorrhoidal Disease: Is Patient's Short-Term Outcome Affected by a Higher Volume of Resected Tissue?.Dig Surg. 2018;35(5):406-410. doi: 10.1159/000480355. Epub 2017 Nov 2.