Details of Disease

General Information of Disease (ID: DISQRITY)

Disease Name	Spinal disease
Synonyms	spinal disease; vertebral column disease or disorder; vertebral column disease; disorder of vertebral column; disease or disorder of vertebral column; disease of vertebral column; disease of spine
Disease Class	FA72: Vertebra disorder
Definition	A disease involving the vertebral column.
Disease Hierarchy	DISWD40R: Disease DIS5PU87: Skeletal system disorder DISQRITY: Spinal disease
ICD Code	ICD-11 ICD-11: FA72 Expand ICD-11 'FA72 Expand ICD-10 'M48; 'M48.8; 'M48.9
Disease Identifiers	MONDO ID MONDO_0000812 MESH ID D013122 UMLS CUI C0037933 MedGen ID 52455 SNOMED CT ID 699699005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SPI-3608	DM8WR5T	Phase 1	NA	[1]
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This Disease is Treated as An Indication in 3 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
KUR-115	DM8I728	Investigative	NA	[2]
KUR-116	DMTM5A9	Investigative	NA	[2]
ST-05	DMVJARM	Investigative	NA	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SMN1	TT8QL6X	Strong	Genetic Variation	[3]
STMN1	TT7W5OT	Strong	Altered Expression	[4]
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This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PENK	OT8P3HMP	Strong	Biomarker	[5]
SMN2	OT54RLO1	Strong	Altered Expression	[4]
SNRPN	OTQB1ID1	Strong	Altered Expression	[4]
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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023520)
2	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3	Antisense Oligonucleotide-Mediated Terminal Intron Retention of the SMN2 Transcript.Mol Ther Nucleic Acids. 2018 Jun 1;11:91-102. doi: 10.1016/j.omtn.2018.01.011. Epub 2018 Jan 31.
4	Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease.Cell Rep. 2017 Feb 7;18(6):1484-1498. doi: 10.1016/j.celrep.2017.01.035.
5	Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholidine in 6-hydroxydopamine-lesioned rats.Acta Pharmacol Sin. 2000 Oct;21(10):885-92.