Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTQB1ID1)

• DOT Name: Small nuclear ribonucleoprotein-associated protein N (SNRPN)
• Synonyms: snRNP-N; Sm protein D; Sm-D; Sm protein N; Sm-N; SmN; Tissue-specific-splicing protein
• Gene Name: SNRPN
• Related Disease:
  Cone-rod dystrophy 2
  Acute undifferentiated leukemia
  Adult glioblastoma
  Adult lymphoma
  Amyotrophic lateral sclerosis
  Arthrogryposis
  Astrocytoma
  Ataxia-telangiectasia
  Autism
  Autism spectrum disorder
  Beckwith-Wiedemann syndrome
  Breast cancer
  Breast carcinoma
  Charcot marie tooth disease
  Epithelial ovarian cancer
  Ewing sarcoma
  Fragile X syndrome
  Glioblastoma multiforme
  Leiomyoma
  Lymphoma
  Male infertility
  Malignant neoplasm
  Motor neurone disease
  Myopathy
  Neurodevelopmental disorder
  Neuromuscular disease
  Obesity
  Osteoarthritis
  Pediatric lymphoma
  Polymyositis
  Prostate cancer
  Prostate carcinoma
  Respiratory failure
  Schizophrenia
  Seminoma
  Small lymphocytic lymphoma
  Spinal disease
  Systemic lupus erythematosus
  Teratoma
  Uterine fibroids
  Mental disorder
  Spinal muscular atrophy, type III
  Germ cell tumor
  Neuroblastoma
• UniProt ID: RSMN_HUMAN
• PDB ID: 5MF9
• Pfam ID: PF01423
• Sequence:
  MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNAKQPE
  REEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGVGRAAGRGVPAGVPI
  PQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAVAATASIAGAPTQYPPGRGTPPPPVG
  RATPPPGIMAPPPGMRPPMGPPIGLPPARGTPIGMPPPGMRPPPPGIRGPPPPGMRPPRP
• Function: May be involved in tissue-specific alternative RNA processing events.
• Tissue Specificity: Expressed in brain and lymphoblasts.
• Reactome Pathway: mRNA Splicing - Major Pathway (R-HSA-72163)

Molecular Interaction Atlas (MIA) of This DOT

44 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Cone-rod dystrophy 2	DISX2RWY	Definitive	Biomarker	[1]
Acute undifferentiated leukemia	DISJ4SSG	Strong	Biomarker	[2]
Adult glioblastoma	DISVP4LU	Strong	Altered Expression	[3]
Adult lymphoma	DISK8IZR	Strong	Biomarker	[4]
Amyotrophic lateral sclerosis	DISF7HVM	Strong	Biomarker	[5]
Arthrogryposis	DISC81CM	Strong	Genetic Variation	[6]
Astrocytoma	DISL3V18	Strong	Altered Expression	[7]
Ataxia-telangiectasia	DISP3EVR	Strong	Biomarker	[8]
Autism	DISV4V1Z	Strong	Altered Expression	[9]
Autism spectrum disorder	DISXK8NV	Strong	Biomarker	[10]
Beckwith-Wiedemann syndrome	DISH15GR	Strong	Genetic Variation	[11]
Breast cancer	DIS7DPX1	Strong	Posttranslational Modification	[12]
Breast carcinoma	DIS2UE88	Strong	Posttranslational Modification	[12]
Charcot marie tooth disease	DIS3BT2L	Strong	Genetic Variation	[13]
Epithelial ovarian cancer	DIS56MH2	Strong	Biomarker	[14]
Ewing sarcoma	DISQYLV3	Strong	Biomarker	[15]
Fragile X syndrome	DISE8W3A	Strong	Genetic Variation	[12]
Glioblastoma multiforme	DISK8246	Strong	Altered Expression	[3]
Leiomyoma	DISLDDFN	Strong	Genetic Variation	[16]
Lymphoma	DISN6V4S	Strong	Biomarker	[4]
Male infertility	DISY3YZZ	Strong	Biomarker	[17]
Malignant neoplasm	DISS6SNG	Strong	Biomarker	[18]
Motor neurone disease	DISUHWUI	Strong	Genetic Variation	[19]
Myopathy	DISOWG27	Strong	Altered Expression	[20]
Neurodevelopmental disorder	DIS372XH	Strong	Biomarker	[21]
Neuromuscular disease	DISQTIJZ	Strong	Biomarker	[22]
Obesity	DIS47Y1K	Strong	Genetic Variation	[23]
Osteoarthritis	DIS05URM	Strong	Biomarker	[17]
Pediatric lymphoma	DIS51BK2	Strong	Biomarker	[4]
Polymyositis	DIS5DHFP	Strong	Biomarker	[24]
Prostate cancer	DISF190Y	Strong	Biomarker	[25]
Prostate carcinoma	DISMJPLE	Strong	Biomarker	[25]
Respiratory failure	DISVMYJO	Strong	Biomarker	[26]
Schizophrenia	DISSRV2N	Strong	Biomarker	[27]
Seminoma	DIS3J8LJ	Strong	Biomarker	[28]
Small lymphocytic lymphoma	DIS30POX	Strong	Genetic Variation	[29]
Spinal disease	DISQRITY	Strong	Altered Expression	[30]
Systemic lupus erythematosus	DISI1SZ7	Strong	Altered Expression	[31]
Teratoma	DIS6ICY4	Strong	Posttranslational Modification	[32]
Uterine fibroids	DISBZRMJ	Strong	Genetic Variation	[16]
Mental disorder	DIS3J5R8	moderate	Biomarker	[21]
Spinal muscular atrophy, type III	DISNG3SD	moderate	Genetic Variation	[33]
Germ cell tumor	DIS62070	Limited	Biomarker	[34]
Neuroblastoma	DISVZBI4	Limited	Biomarker	[35]

16 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate decreases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[36]
Doxorubicin	DMVP5YE	Approved	Doxorubicin increases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[37]
Cupric Sulfate	DMP0NFQ	Approved	Cupric Sulfate decreases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[38]
Cisplatin	DMRHGI9	Approved	Cisplatin decreases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[39]
Hydrogen peroxide	DM1NG5W	Approved	Hydrogen peroxide increases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[40]
Vorinostat	DMWMPD4	Approved	Vorinostat decreases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[41]
Triclosan	DMZUR4N	Approved	Triclosan decreases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[42]
Folic acid	DMEMBJC	Approved	Folic acid decreases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[43]
Demecolcine	DMCZQGK	Approved	Demecolcine decreases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[44]
Testosterone enanthate	DMB6871	Approved	Testosterone enanthate affects the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[45]
Atenolol	DMNKG1Z	Approved	Atenolol increases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[46]
SNDX-275	DMH7W9X	Phase 3	SNDX-275 affects the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[47]
(+)-JQ1	DM1CZSJ	Phase 1	(+)-JQ1 decreases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[49]
Trichostatin A	DM9C8NX	Investigative	Trichostatin A increases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[36]
Formaldehyde	DM7Q6M0	Investigative	Formaldehyde decreases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[44]
Milchsaure	DM462BT	Investigative	Milchsaure increases the expression of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[52]

3 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the methylation of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[48]
PMID28870136-Compound-52	DMFDERP	Patented	PMID28870136-Compound-52 decreases the phosphorylation of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[50]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the methylation of Small nuclear ribonucleoprotein-associated protein N (SNRPN).	[51]

References

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