Details of Disease

General Information of Disease (ID: DISSHV10)

• Disease Name: Coronary vasospasm
• Synonyms: coronary artery vasospasm; coronary vasospasm; coronary artery spasm
• Definition: Sudden coronary artery smooth muscle contraction leading to lumen constriction and decreased blood flow.
• Disease Hierarchy:
  DIS5OIP1: Coronary heart disease
  DISSHV10: Coronary vasospasm
• Disease Identifiers:
  MONDO ID: MONDO_0005356
  MESH ID: D003329
  UMLS CUI: C0010073
  MedGen ID: 3626
  HPO ID: HP:0025497
  SNOMED CT ID: 23687008

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
NOS3	TTCM4B3	Limited	Genetic Variation	[1]
PON1	TT9LX82	Limited	Genetic Variation	[2]
ABCC9	TTEF5MJ	Strong	Genetic Variation	[3]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SGCD	OTRBL3NQ	moderate	Genetic Variation	[4]
ARHGAP9	OTJNHX96	Strong	Biomarker	[5]
MED23	OTKZQT0R	Strong	Biomarker	[6]
PLCD1	OT6WFVXZ	Strong	Altered Expression	[7]

References

• [1] Determinants of Myocardial Lactate Production During Acetylcholine Provocation Test in Patients With Coronary Spasm.J Am Heart Assoc. 2015 Dec 11;4(12):e002387. doi: 10.1161/JAHA.115.002387.
• [2] First survey of the three gene polymorphisms (PON1 Q192R, eNOS E298D and eNOS C-786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data.Cell Biochem Funct. 2011 Mar;29(2):156-63. doi: 10.1002/cbf.1721. Epub 2011 Feb 2.
• [3] Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9.Int J Cardiol. 2013 Oct 9;168(4):3506-13. doi: 10.1016/j.ijcard.2013.04.210. Epub 2013 Jun 3.
• [4] A delta-sarcoglycan gene polymorphism as a risk factor for hypertrophic cardiomyopathy.Genet Test Mol Biomarkers. 2012 Aug;16(8):855-8. doi: 10.1089/gtmb.2011.0343. Epub 2012 Apr 23.
• [5] Mutation of ARHGAP9 in patients with coronary spastic angina.J Hum Genet. 2010 Jan;55(1):42-9. doi: 10.1038/jhg.2009.120. Epub 2009 Nov 13.
• [6] Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K(ATP) channels.J Clin Invest. 2002 Jul;110(2):203-8. doi: 10.1172/JCI15672.
• [7] Enhanced transient receptor potential channel-mediated Ca(2+) influx in the cells with phospholipase C-1 overexpression: its possible role in coronary artery spasm.Fundam Clin Pharmacol. 2017 Aug;31(4):383-391. doi: 10.1111/fcp.12269. Epub 2017 Feb 16.