Details of Disease

General Information of Disease (ID: DIST3QD3)

Disease Name Leukoplakia
Synonyms lesions, leukoplakic; leukoplakic lesion; leukoplakic lesions; leukoplakias; leukokeratosis; leukokeratoses; lesion, leukoplakic; leukoplakia; keratotic plaque
Definition
A white patch or plaque on a mucous membrane that cannot be characterized clinically or pathologically as any other disease. The diagnosis of leukoplakia is one of exclusion; other conditions such as candidiasis, lichen planus, leukoedema, etc., must be ruled out before a diagnosis of leukoplakia can be made. Leukoplakia may be a premalignant condition.
Disease Hierarchy
DISV06FL: Precancerous condition
DIST3QD3: Leukoplakia
Disease Identifiers
MONDO ID
MONDO_0043243
MESH ID
D007971
UMLS CUI
C0023531
MedGen ID
44133
SNOMED CT ID
274134003

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
EIF5A2 TTH53G9 Limited Genetic Variation [1]
SIK1 TT1H6LC Limited Biomarker [2]
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This Disease Is Related to 1 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
TGM3 DEOEB3Q Limited Biomarker [3]
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This Disease Is Related to 17 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
DERL3 OTRZRT6Q Limited Genetic Variation [1]
ECT2 OTQDUCT6 Limited Genetic Variation [1]
HOXC13 OT52AVNA Limited Genetic Variation [1]
HOXC9 OT60K4M0 Limited Genetic Variation [1]
KRT13 OTTYSKGX Limited Altered Expression [4]
KRT4 OT24PHPM Limited Altered Expression [3]
LTO1 OTQ17ZDT Limited Biomarker [5]
MFAP5 OT46VXSG Limited Genetic Variation [1]
MTUS1 OTBPALMU Limited Altered Expression [6]
NELL2 OTS4MJZ7 Limited Genetic Variation [1]
POLG2 OTDBMZJB Limited Biomarker [7]
POLRMT OT5Q8ZUJ Limited Genetic Variation [7]
CTTN OTJRG4ES moderate Altered Expression [8]
GSTM3 OTLA2WJT Strong Genetic Variation [9]
PABPN1 OT3MC5SE Strong Biomarker [10]
PIWIL2 OT1PXQIF Strong Altered Expression [11]
RRAS2 OT83NCEB Strong Altered Expression [12]
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⏷ Show the Full List of 17 DOT(s)

References

1 Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer.Transl Oncol. 2017 Jun;10(3):396-409. doi: 10.1016/j.tranon.2017.03.008. Epub 2017 Apr 21.
2 PPAR-Mediated p21 Induction in Aerodigestive Preneoplastic Cell Lines.Ann Otol Rhinol Laryngol. 2018 Oct;127(10):677-686. doi: 10.1177/0003489418787833. Epub 2018 Jul 26.
3 Differential expression of the keratin-4, -13, -14, -17 and transglutaminase 3 genes during the development of oral squamous cell carcinoma from leukoplakia.Oral Oncol. 2005 Jul;41(6):607-13. doi: 10.1016/j.oraloncology.2005.01.011. Epub 2005 Apr 14.
4 Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma.J Cancer Res Clin Oncol. 2012 Aug;138(8):1299-310. doi: 10.1007/s00432-012-1202-6. Epub 2012 Apr 3.
5 Amplifications of TAOS1 and EMS1 genes in oral carcinogenesis: association with clinicopathological features.Oral Oncol. 2007 May;43(5):508-14. doi: 10.1016/j.oraloncology.2006.05.008. Epub 2006 Sep 26.
6 Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma.Mol Oncol. 2012 Feb;6(1):73-80. doi: 10.1016/j.molonc.2011.11.002. Epub 2011 Nov 18.
7 Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer.Gene. 2016 Jan 10;575(2 Pt 3):650-4. doi: 10.1016/j.gene.2015.09.039. Epub 2015 Sep 25.
8 Cortactin is a prognostic marker for oral squamous cell carcinoma and its overexpression is involved in oral carcinogenesis.Environ Toxicol. 2017 Mar;32(3):799-812. doi: 10.1002/tox.22280. Epub 2016 May 5.
9 Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers carrying two risk genotypes: one on each of two loci, GSTM3 and XRCC1 (Codon 280).Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2106-12. doi: 10.1158/1055-9965.EPI-05-0108.
10 Variants in FAT1 and COL9A1 genes in male population with or without substance use to assess the risk factors for oral malignancy.PLoS One. 2019 Jan 18;14(1):e0210901. doi: 10.1371/journal.pone.0210901. eCollection 2019.
11 Expression of PIWIL2 in oral cancer and leukoplakia: Prognostic implications and insights from tumors.Cancer Biomark. 2019;26(1):11-20. doi: 10.3233/CBM-182009.
12 Clinical significance of TC21 overexpression in oral cancer.J Oral Pathol Med. 2010 Jul;39(6):477-85. doi: 10.1111/j.1600-0714.2009.00854.x. Epub 2009 Dec 16.