Details of Disease

General Information of Disease (ID: DISV06FL)

Disease Name Precancerous condition
Synonyms precancerous condition; precancerous state; premalignant condition; premalignant state
Definition
A pathological process with signs indicating it may become cancerous. Representative examples include leukoplakia, dysplastic nevus, actinic keratosis, xeroderma pigmentosum, and intraepithelial neoplasia.|Editor note: check classification. Also consider changing def, NCIT defines as disease. Also consider a grouping for this and paraneoplastic syndrome
Disease Hierarchy
DIS11CME: Cell proliferative disorder
DISV06FL: Precancerous condition
Disease Identifiers
MONDO ID
MONDO_0021074
MESH ID
D011230
UMLS CUI
C0032927
MedGen ID
19442

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Celecoxib DM6LOQU Approved Small molecular drug [1]
Rosuvastatin DMMIQ7G Approved Small molecular drug [2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 57 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ALDH2 TTFLN4T Limited Biomarker [3]
CPS1 TT42M75 Limited Biomarker [3]
CSK TTX6F0Q Limited Biomarker [4]
GSTO1 TTWO3SH Limited Biomarker [3]
PEBP1 TT1BGU8 Limited Biomarker [3]
PRKG1 TT7IZSA Limited Biomarker [3]
PSCA TT9T4AV Limited Biomarker [5]
SIRPA TTBRJS9 Limited Biomarker [3]
ABL1 TT6B75U Disputed Biomarker [6]
HRAS TT28ZON Disputed Altered Expression [7]
CDH1 TTLAWO6 moderate Genetic Variation [8]
MGMT TTJ8DV7 moderate Biomarker [9]
STAT3 TTHJT3X moderate Biomarker [10]
ACAT1 TTK3C21 Strong Altered Expression [11]
AKT1 TTWTSCV Strong Biomarker [12]
ARG1 TT7ZQEV Strong Biomarker [13]
BCAT2 TTF9OQ6 Strong Biomarker [6]
CAT TTPS279 Strong Biomarker [14]
CCND1 TTFCJ7S Strong Altered Expression [15]
CDC25B TTR0SWN Strong Biomarker [16]
CEBPA TT5LWG1 Strong Biomarker [17]
CHN2 TT39YVO Strong Biomarker [6]
CTDSP1 TTHZAF0 Strong Biomarker [18]
CTSA TT5NILS Strong Genetic Variation [19]
DPP10 TTOVUPC Strong Biomarker [6]
EGF TTED8JB Strong Biomarker [20]
EIF4EBP1 TTKGEBL Strong Biomarker [21]
FBXO11 TT6G10V Strong Biomarker [22]
FOSL2 TT689IR Strong Altered Expression [23]
FOXM1 TTD3KOX Strong Altered Expression [24]
FTH1 TT975ZT Strong Biomarker [17]
GALR1 TTX3HNZ Strong Genetic Variation [25]
GJB1 TTSJIRP Strong Biomarker [26]
GSTP1 TT40K12 Strong Biomarker [27]
HDC TTV9GOF Strong Altered Expression [28]
IGF2 TTE8WGO Strong Altered Expression [29]
IGFBP1 TTCJTWF Strong Therapeutic [30]
IMP3 TTEJA2R Strong Biomarker [31]
IRS1 TTAJSQ0 Strong Biomarker [32]
KLK6 TTLPF4X Strong Altered Expression [33]
MAP2K7 TT6QY3J Strong Biomarker [34]
MAPK8 TT0K6EO Strong Biomarker [34]
MAPK9 TT3IVG2 Strong Biomarker [34]
MDM2 TT9TE0O Strong Biomarker [35]
MPO TTVCZPI Strong Genetic Variation [14]
MUC1 TTBHFYQ Strong Biomarker [36]
NR1I3 TTRANFM Strong Biomarker [37]
PGC TT7K6AD Strong Genetic Variation [38]
PHB TT6U071 Strong Biomarker [39]
PIM1 TTTN5QW Strong Biomarker [21]
PSEN2 TTWN3F4 Strong Altered Expression [40]
RSPO3 TT7HJTF Strong Biomarker [41]
SERPINB3 TT6QLPX Strong Biomarker [39]
SORD TTLSRBZ Strong Altered Expression [42]
TFF1 TTNOJIZ Strong Altered Expression [43]
TNK2 TTIET93 Strong Biomarker [6]
RARB TTISP28 Definitive Altered Expression [44]
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⏷ Show the Full List of 57 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC52A3 DTBVQIO moderate Biomarker [5]
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This Disease Is Related to 4 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
AS3MT DE9KJP3 Strong Genetic Variation [45]
GSTA4 DEH7XYP Strong Biomarker [46]
MAT1A DEQ6NC9 Strong Altered Expression [11]
UGT1A9 DE85D2P Strong Altered Expression [47]
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This Disease Is Related to 110 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACTC1 OTJU04B1 Limited Biomarker [3]
ACY1 OT9WU7X3 Limited Biomarker [3]
ALDH4A1 OT25Z6XH Limited Biomarker [3]
AOPEP OT0MMANL Limited Biomarker [3]
ATP5F1B OTLFZUQK Limited Biomarker [3]
CFL1 OTT6D5MH Limited Biomarker [3]
CKB OTUCKOTT Limited Altered Expression [48]
COG4 OT6U94UE Limited Biomarker [3]
COL23A1 OTYE0N3I Limited Biomarker [3]
ERGIC3 OT8RWHN3 Limited Biomarker [49]
G3BP2 OTAWW3KI Limited Altered Expression [50]
HADH OTJDOL20 Limited Biomarker [3]
HYAL2 OTTVINXW Limited Biomarker [51]
KRT8 OTTM4X11 Limited Biomarker [3]
PBLD OTI3A8RS Limited Biomarker [3]
PDLIM7 OTAZVODU Limited Biomarker [52]
PRKAA1 OT7TNF0L Limited Biomarker [5]
PSD2 OTYQUH5I Limited Biomarker [3]
RABEP2 OTO61X27 Limited Altered Expression [50]
TRIT1 OTCU9FS5 Limited Biomarker [3]
G0S2 OT8FL49L moderate Biomarker [53]
HPR OTXSC9UB moderate Biomarker [54]
PDZK1IP1 OTWA6M5K moderate Altered Expression [55]
ACSS1 OT6C1WQD Strong Altered Expression [56]
AGO1 OTD3R434 Strong Biomarker [57]
ANXA4 OTUCRYXL Strong Biomarker [6]
ASAP2 OTGEXULW Strong Biomarker [58]
ASPRV1 OT8WVIBW Strong Biomarker [59]
BARD1 OTTC0Z9Y Strong Biomarker [60]
BMP5 OTC0Y6E0 Strong Biomarker [61]
BTRC OT2EZDGR Strong Biomarker [62]
CCDC134 OT70OQQV Strong Biomarker [6]
CCNA1 OTX4HD45 Strong Posttranslational Modification [63]
CD2AP OTC76KQM Strong Biomarker [64]
CDH17 OT9EV2XK Strong Altered Expression [65]
CDX1 OTOHTMJE Strong Altered Expression [66]
CDX2 OTCG4TSY Strong Biomarker [67]
CISH OT8T5NYL Strong Biomarker [21]
CKS1B OTNUPLUJ Strong Biomarker [68]
CREBZF OTO3TOEU Strong Biomarker [22]
CSHL1 OTQKU2F5 Strong Biomarker [69]
CST6 OTZVHJTF Strong Altered Expression [70]
CTNND1 OTUMPSHR Strong Biomarker [71]
DDX54 OTVOJU6G Strong Biomarker [6]
DGCR8 OT62LXE4 Strong Biomarker [57]
EFNB2 OT0DCUOM Strong Biomarker [6]
EIF3E OTI0WG98 Strong Altered Expression [72]
ENDOV OTX2GXXX Strong Biomarker [73]
ESRP1 OTNCS4SL Strong Biomarker [74]
EXOSC2 OTN6NVKL Strong Biomarker [6]
EYA4 OTINGR3Z Strong Altered Expression [75]
GKN2 OTR9DOYG Strong Biomarker [76]
HIGD2A OTX1K4IH Strong Biomarker [6]
HOXA9 OTKNK5H0 Strong Biomarker [77]
HTRA3 OTXJ0H4X Strong Altered Expression [78]
IFITM1 OTECO1G8 Strong Biomarker [79]
IFT88 OTDR3VBD Strong Biomarker [80]
INTS6 OT6GDV46 Strong Altered Expression [72]
KIF1A OT3JVEGV Strong Biomarker [81]
KLF9 OTBFEJRQ Strong Altered Expression [82]
KRT14 OTUVZ1DW Strong Altered Expression [83]
LDOC1 OTWZH4O9 Strong Altered Expression [84]
MAPK15 OT8SW0L7 Strong Biomarker [85]
MRPS30 OTDXIAGG Strong Biomarker [58]
MTPAP OT6HQ02S Strong Biomarker [58]
MYBL2 OTZ3JX8Q Strong Altered Expression [86]
MYT1L OTV45MAS Strong Biomarker [87]
NOL7 OTIJ1KQI Strong Altered Expression [88]
NOLC1 OTKDZU0D Strong Altered Expression [89]
NOP16 OT2829ZC Strong Biomarker [6]
OTUD4 OT7U62SW Strong Altered Expression [90]
PAPOLA OTPHD65D Strong Biomarker [58]
PDAP1 OTJSWMOD Strong Biomarker [58]
PIAS3 OT3TWH9R Strong Biomarker [91]
PIWIL2 OT1PXQIF Strong Altered Expression [92]
PRDX1 OTZ3BEC4 Strong Biomarker [39]
PRICKLE2 OTWBA48T Strong Biomarker [6]
PRIMA1 OT9ITT3P Strong Biomarker [93]
PSG1 OT1U4ZZW Strong Biomarker [94]
RAB3GAP1 OT4DQ8F2 Strong Altered Expression [89]
RBL2 OTBQSOE6 Strong Altered Expression [89]
RBMX OTFZN66E Strong Altered Expression [95]
S100A7 OTJFVJRF Strong Biomarker [96]
SCGB3A1 OTIR98RB Strong Altered Expression [90]
SCPEP1 OT43LYEZ Strong Biomarker [18]
SDHB OTRE1M1T Strong Altered Expression [42]
SFXN1 OTL66767 Strong Genetic Variation [97]
SIX3 OTP5E3VU Strong Biomarker [6]
SMPX OTLSHGBF Strong Biomarker [69]
SOCS4 OTIRULFZ Strong Biomarker [21]
ST3GAL4 OTNENJZQ Strong Altered Expression [98]
STAT5A OTBSJGN3 Strong Biomarker [99]
SULF1 OTJCNCO0 Strong Biomarker [100]
SYCP1 OTWFV4KA Strong Biomarker [18]
TARBP2 OT1QQ8H3 Strong Biomarker [57]
TFF2 OTRXB19X Strong Altered Expression [43]
TLX1 OTVN0MNW Strong Biomarker [101]
TMEM132D OTV6I4Z0 Strong Biomarker [6]
TMOD4 OTXLGJ4R Strong Altered Expression [102]
TPM4 OTN4YLYR Strong Biomarker [39]
TRIO OT71X1AK Strong Biomarker [6]
TSC2 OT47LWI9 Strong Biomarker [21]
TSKS OT5LZ6GG Strong Altered Expression [103]
TTLL9 OT1M1SZH Strong Biomarker [6]
ALOX15B OTWQQ08W Definitive Altered Expression [104]
PELP1 OTVXQNOT Definitive Altered Expression [105]
RRBP1 OT4ZTPTM Definitive Genetic Variation [106]
SEM1 OTASLBM1 Definitive Biomarker [107]
SFRP1 OT0U9G41 Definitive Biomarker [108]
SLURP1 OT89YD2E Definitive Altered Expression [109]
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⏷ Show the Full List of 110 DOT(s)

References

1 Celecoxib FDA Label
2 Rosuvastatin FDA Label
3 Hepatocellular carcinoma-associated protein markers investigated by MALDI-TOF MS.Mol Med Rep. 2010 Jul-Aug;3(4):589-96. doi: 10.3892/mmr_00000302.
4 Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation.FEBS Lett. 2005 Jul 4;579(17):3497-502. doi: 10.1016/j.febslet.2005.05.030.
5 Environmental factors, seven GWAS-identified susceptibility loci, and risk of gastric cancer and its precursors in a Chinese population.Cancer Med. 2017 Mar;6(3):708-720. doi: 10.1002/cam4.1038. Epub 2017 Feb 21.
6 Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.Toxicol Sci. 2009 Apr;108(2):273-89. doi: 10.1093/toxsci/kfp031. Epub 2009 Feb 20.
7 BRCA1 affects global DNA methylation through regulation of DNMT1.Cell Res. 2010 Nov;20(11):1201-15. doi: 10.1038/cr.2010.128. Epub 2010 Sep 7.
8 E-cadherin polymorphisms and susceptibility to arsenic-related skin lesions in West Bengal, India.Sci Total Environ. 2012 Mar 15;420:65-72. doi: 10.1016/j.scitotenv.2012.01.007. Epub 2012 Feb 11.
9 Promoter region hypermethylation and mRNA expression of MGMT and p16 genes in tissue and blood samples of human premalignant oral lesions and oral squamous cell carcinoma.Biomed Res Int. 2014;2014:248419. doi: 10.1155/2014/248419. Epub 2014 Jun 2.
10 Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations.Am J Physiol Gastrointest Liver Physiol. 2019 Feb 1;316(2):G251-G262. doi: 10.1152/ajpgi.00304.2018. Epub 2018 Dec 6.
11 The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis.Cancer Res. 1998 Dec 1;58(23):5500-6.
12 Salvianolic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1 signaling pathway.Cell Death Dis. 2018 May 22;9(6):599. doi: 10.1038/s41419-018-0623-9.
13 Interleukin-17A Promotes Arginase-1 Production and 2,4-Dinitrochlorobenzene-Induced Acute Hyperinflammation in Human Papillomavirus E7 Oncoprotein-Expressing Skin.J Innate Immun. 2015;7(4):392-404. doi: 10.1159/000374115. Epub 2015 Feb 14.
14 Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase. Cancer Lett. 2003 Nov 10;201(1):57-65. doi: 10.1016/s0304-3835(03)00471-3.
15 Asymmetrical proliferative pattern loss linked to cyclin D1 overexpression in adjacent non-tumour epithelium in oral squamous cell carcinoma.Arch Oral Biol. 2019 Jan;97:12-17. doi: 10.1016/j.archoralbio.2018.10.007. Epub 2018 Oct 9.
16 CDC25B and CDC25C overexpression in nonmelanoma skin cancer suppresses cell death.Mol Carcinog. 2019 Sep;58(9):1691-1700. doi: 10.1002/mc.23075. Epub 2019 Jun 24.
17 Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver.Toxicol Sci. 2011 Oct;123(2):433-40. doi: 10.1093/toxsci/kfr193. Epub 2011 Jul 23.
18 Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis.Int J Cancer. 2004 Apr 20;109(4):568-75. doi: 10.1002/ijc.20006.
19 Suicide gene therapy for premalignant disease: a new strategy for the treatment of intraepithelial neoplasia.Gene Ther. 2001 Feb;8(3):232-8. doi: 10.1038/sj.gt.3301344.
20 Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.Nat Med. 2015 Oct;21(10):1163-71. doi: 10.1038/nm.3952. Epub 2015 Sep 21.
21 Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.Neoplasia. 2015 Jul;17(7):586-97. doi: 10.1016/j.neo.2015.07.005.
22 Potential miRNA-target interactions for the screening of gastric carcinoma development in gastric adenoma/dysplasia.Int J Med Sci. 2018 Mar 14;15(6):610-616. doi: 10.7150/ijms.24061. eCollection 2018.
23 Microenvironmental regulation of BRCA1 gene expression by c-Jun and Fra2 in premalignant human ovarian surface epithelial cells.Mol Cancer Res. 2013 Mar;11(3):272-81. doi: 10.1158/1541-7786.MCR-12-0395. Epub 2013 Jan 21.
24 FOXM1 is a novel predictor of recurrence in patients with oral squamous cell carcinoma associated with an increase in epithelialmesenchymal transition.Mol Med Rep. 2019 May;19(5):4101-4108. doi: 10.3892/mmr.2019.10094. Epub 2019 Mar 27.
25 GALR1 methylation in vaginal swabs is highly accurate in identifying women with endometrial cancer.Int J Gynecol Cancer. 2013 Jul;23(6):1050-5. doi: 10.1097/IGC.0b013e3182959103.
26 Changes in gap junction protein (connexin 32) gene expression during rat liver carcinogenesis.J Cell Biochem. 1989 Oct;41(2):97-102. doi: 10.1002/jcb.240410206.
27 The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene.Mutat Res. 2011 Jun 17;722(2):106-13. doi: 10.1016/j.mrgentox.2010.02.011. Epub 2010 Feb 25.
28 Bile acid increases expression of the histamine-producing enzyme, histidine decarboxylase, in gastric cells.World J Gastroenterol. 2014 Jan 7;20(1):175-82. doi: 10.3748/wjg.v20.i1.175.
29 Hypomethylated P4 promoter induces expression of the insulin-like growth factor-II gene in hepatocellular carcinoma in a Chinese population.Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4171-7. doi: 10.1158/1078-0432.CCR-05-2261.
30 Insulin-like growth factor binding protein-1 over-expression in transgenic mice inhibits hepatic preneoplasia.Mol Carcinog. 2003 Mar;36(3):142-6. doi: 10.1002/mc.10105.
31 Expression and clinical significance of IMP3 in microdissected premalignant and malignant pancreatic lesions.Clin Transl Oncol. 2015 Mar;17(3):215-22. doi: 10.1007/s12094-014-1216-4. Epub 2014 Sep 3.
32 Overexpression of insulin receptor substrate-1 emerges early in hepatocarcinogenesis and elicits preneoplastic hepatic glycogenosis.Am J Pathol. 1998 Feb;152(2):341-5.
33 Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer.Cancer. 2011 Jun 15;117(12):2608-19. doi: 10.1002/cncr.25841. Epub 2010 Dec 23.
34 The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.Nat Genet. 2011 Mar;43(3):212-9. doi: 10.1038/ng.767. Epub 2011 Feb 13.
35 Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells.Cancer Res. 2017 Jul 15;77(14):3823-3833. doi: 10.1158/0008-5472.CAN-17-0809. Epub 2017 Jun 2.
36 Clinical associations of mucin 1 in human lung cancer and precancerous lesions.Oncotarget. 2018 Nov 2;9(86):35666-35675. doi: 10.18632/oncotarget.26278. eCollection 2018 Nov 2.
37 Involvement of constitutive androstane receptor in liver hypertrophy and liver tumor development induced by triazole fungicides.Food Chem Toxicol. 2015 Apr;78:86-95. doi: 10.1016/j.fct.2015.01.021. Epub 2015 Feb 2.
38 Impact of pepsinogen C polymorphism on individual susceptibility to gastric cancer and its precancerous conditions in a Northeast Chinese population.J Cancer Res Clin Oncol. 2009 Aug;135(8):1033-9. doi: 10.1007/s00432-008-0539-3. Epub 2009 Jan 9.
39 Comparative proteomic analysis of esophageal squamous cell carcinoma.Proteomics. 2005 Jul;5(11):2960-71. doi: 10.1002/pmic.200401175.
40 Differential expression of the pS2 protein in the human prostate and prostate cancer: association with premalignant changes and neuroendocrine differentiation.Hum Pathol. 1995 Aug;26(8):824-8. doi: 10.1016/0046-8177(95)90002-0.
41 A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion.Nat Commun. 2019 Dec 2;10(1):5490. doi: 10.1038/s41467-019-13330-y.
42 Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells.Cancer Lett. 2019 Jul 1;453:95-106. doi: 10.1016/j.canlet.2019.03.039. Epub 2019 Mar 28.
43 Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer.World J Gastroenterol. 2006 May 21;12(19):3119-22. doi: 10.3748/wjg.v12.i19.3119.
44 The abnormal expression of retinoic acid receptor-beta, p 53 and Ki67 protein in normal, premalignant and malignant esophageal tissues.World J Gastroenterol. 2002 Apr;8(2):200-2. doi: 10.3748/wjg.v8.i2.200.
45 Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions.Toxicol Appl Pharmacol. 2009 Sep 1;239(2):200-7. doi: 10.1016/j.taap.2009.06.007. Epub 2009 Jun 16.
46 Glutathione S-transferase A4 is a positive marker for rat hepatic foci induced by clofibrate and genotoxic carcinogens.Cancer Sci. 2010 May;101(5):1093-8. doi: 10.1111/j.1349-7006.2010.01508.x. Epub 2010 Jan 22.
47 Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer.Cancer Res. 1997 Jul 15;57(14):2979-85.
48 Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer.Cancer Res. 2006 Jan 15;66(2):763-9. doi: 10.1158/0008-5472.CAN-05-3771.
49 Endoplasmic reticulum-Golgi intermediate compartment protein 3 knockdown suppresses lung cancer through endoplasmic reticulum stress-induced autophagy.Oncotarget. 2016 Oct 4;7(40):65335-65347. doi: 10.18632/oncotarget.11678.
50 Carcinogenic Helicobacter pylori Strains Selectively Dysregulate the In Vivo Gastric Proteome, Which May Be Associated with Stomach Cancer Progression.Mol Cell Proteomics. 2019 Feb;18(2):352-371. doi: 10.1074/mcp.RA118.001181. Epub 2018 Nov 19.
51 Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.BMC Cancer. 2013 Apr 5;13:181. doi: 10.1186/1471-2407-13-181.
52 Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells.Oncogene. 2007 May 10;26(21):3069-80. doi: 10.1038/sj.onc.1210106. Epub 2006 Nov 13.
53 Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice.PLoS Genet. 2017 May 1;13(5):e1006716. doi: 10.1371/journal.pgen.1006716. eCollection 2017 May.
54 4-HPR modulates gene expression in ovarian cells. Int J Cancer. 2006 Sep 1;119(5):1005-13. doi: 10.1002/ijc.21797.
55 Identification of a novel gene, selectively up-regulated in human carcinomas, using the differential display technique.Clin Cancer Res. 1995 Oct;1(10):1209-15.
56 Downregulation of acetyl-CoA synthetase 2 is a metabolic hallmark of tumor progression and aggressiveness in colorectal carcinoma.Mod Pathol. 2017 Feb;30(2):267-277. doi: 10.1038/modpathol.2016.172. Epub 2016 Oct 7.
57 Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.Mol Carcinog. 2012 Nov;51(11):916-22. doi: 10.1002/mc.20861. Epub 2011 Oct 24.
58 Detection of HPV and ras gene mutations in cervical smears from female genital lesions.Oncol Rep. 1998 Sep-Oct;5(5):1195-8. doi: 10.3892/or.5.5.1195.
59 A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.PLoS One. 2010 Feb 12;5(2):e9188. doi: 10.1371/journal.pone.0009188.
60 In vitro repression of Brca1-associated RING domain gene, Bard1, induces phenotypic changes in mammary epithelial cells.J Cell Biol. 1998 Nov 30;143(5):1329-39. doi: 10.1083/jcb.143.5.1329.
61 Overexpression of BMP-2/4, -5 and BMPR-IA associated with malignancy of oral epithelium.Oral Oncol. 2001 Apr;37(3):225-33. doi: 10.1016/s1368-8375(00)00087-7.
62 Expediting dynamics approach to understand the influence of 14-3-3 causing metastatic cancer through the interaction of YAP1 and -TRCP.Mol Biosyst. 2017 Sep 26;13(10):1981-1992. doi: 10.1039/c7mb00271h.
63 Cyclin A1 promoter hypermethylation in human papillomavirus-associated cervical cancer.BMC Cancer. 2006 Mar 8;6:55. doi: 10.1186/1471-2407-6-55.
64 Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis.Aging Cell. 2014 Jun;13(3):487-96. doi: 10.1111/acel.12197. Epub 2014 Mar 4.
65 Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma.Hepatology. 2009 Nov;50(5):1453-63. doi: 10.1002/hep.23143.
66 CDX1 Expression Induced by CagA-Expressing Helicobacter pylori Promotes Gastric Tumorigenesis.Mol Cancer Res. 2019 Nov;17(11):2169-2183. doi: 10.1158/1541-7786.MCR-19-0181. Epub 2019 Aug 15.
67 The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms.J Exp Med. 2018 Mar 5;215(3):911-926. doi: 10.1084/jem.20170934. Epub 2018 Feb 8.
68 EBV latent membrane protein 2A orchestrates p27(kip1) degradation via Cks1 to accelerate MYC-driven lymphoma in mice.Blood. 2017 Dec 7;130(23):2516-2526. doi: 10.1182/blood-2017-07-796821. Epub 2017 Oct 26.
69 Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation.Nat Cell Biol. 2015 Sep;17(9):1193-204. doi: 10.1038/ncb3228. Epub 2015 Aug 24.
70 DNA methylation-dependent silencing of CST6 in human breast cancer cell lines.Lab Invest. 2006 Dec;86(12):1233-42. doi: 10.1038/labinvest.3700485. Epub 2006 Oct 16.
71 p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia.Cancer Res. 2016 Jun 1;76(11):3351-63. doi: 10.1158/0008-5472.CAN-15-2268. Epub 2016 Mar 31.
72 Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis.Breast Cancer Res. 2007;9(4):R42. doi: 10.1186/bcr1742.
73 Effect of xenogenic repair enzymes on photoimmunology and photocarcinogenesis.J Photochem Photobiol B. 2001 Dec 31;65(2-3):105-8. doi: 10.1016/s1011-1344(01)00246-9.
74 Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells.Cancer Res. 2018 Apr 15;78(8):1986-1999. doi: 10.1158/0008-5472.CAN-17-0315. Epub 2018 Feb 5.
75 Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus.J Exp Clin Cancer Res. 2009 Nov 25;28(1):145. doi: 10.1186/1756-9966-28-145.
76 Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression.J Clin Invest. 2016 Apr 1;126(4):1383-400. doi: 10.1172/JCI82655. Epub 2016 Mar 14.
77 HOXA9 mediates and marks premalignant compartment size expansion in colonic adenomas.Carcinogenesis. 2019 Dec 31;40(12):1514-1524. doi: 10.1093/carcin/bgz038.
78 Hypoxia is involved in the reduction of HtrA3 in patients with endometrial hyperplasia and cancer.Biochem Biophys Res Commun. 2018 Sep 18;503(4):2918-2923. doi: 10.1016/j.bbrc.2018.08.070. Epub 2018 Aug 20.
79 Gene expression profiling in human gastric mucosa infected with Helicobacter pylori.Mod Pathol. 2007 Sep;20(9):974-89. doi: 10.1038/modpathol.3800930. Epub 2007 Jul 20.
80 The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene.Oncogene. 1997 Oct 9;15(15):1797-803. doi: 10.1038/sj.onc.1201535.
81 Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy.Cancer Prev Res (Phila). 2010 Sep;3(9):1093-103. doi: 10.1158/1940-6207.CAPR-10-0115. Epub 2010 Aug 26.
82 KLF9-dependent ROS regulate melanoma progression in stage-specific manner.Oncogene. 2019 May;38(19):3585-3597. doi: 10.1038/s41388-019-0689-6. Epub 2019 Jan 21.
83 Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation.Carcinogenesis. 2008 Dec;29(12):2377-84. doi: 10.1093/carcin/bgn190. Epub 2008 Aug 12.
84 LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation.Oncotarget. 2015 Sep 22;6(28):25188-201. doi: 10.18632/oncotarget.4512.
85 Overexpression of MAPK15 in gastric cancer is associated with copy number gain and contributes to the stability of c-Jun.Oncotarget. 2015 Aug 21;6(24):20190-203. doi: 10.18632/oncotarget.4171.
86 Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.J Hepatol. 2011 Jul;55(1):111-9. doi: 10.1016/j.jhep.2010.10.031. Epub 2010 Dec 7.
87 From the Cover: Neutralization of terminal differentiation in gliomagenesis.Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14520-7. doi: 10.1073/pnas.1308610110. Epub 2013 Aug 5.
88 The RB tumor suppressor positively regulates transcription of the anti-angiogenic protein NOL7.Neoplasia. 2012 Dec;14(12):1213-22. doi: 10.1593/neo.121422.
89 Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors.Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9391-E9400. doi: 10.1073/pnas.1808903115. Epub 2018 Sep 13.
90 Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract.Int J Cancer. 2011 Oct 15;129(8):1889-98. doi: 10.1002/ijc.25847. Epub 2011 Mar 11.
91 STAT3/PIAS3 Levels Serve as "Early Signature" Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube.Cancer Res. 2018 Apr 1;78(7):1739-1750. doi: 10.1158/0008-5472.CAN-17-1671. Epub 2018 Jan 16.
92 Expression of PIWIL2 in oral cancer and leukoplakia: Prognostic implications and insights from tumors.Cancer Biomark. 2019;26(1):11-20. doi: 10.3233/CBM-182009.
93 Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway.Mol Cancer Ther. 2005 Jun;4(6):901-9. doi: 10.1158/1535-7163.MCT-04-0206.
94 Recombinant Pregnancy-Specific Glycoprotein 1 Has a Protective Role in a Murine Model of Acute Graft-versus-Host Disease.Biol Blood Marrow Transplant. 2019 Feb;25(2):193-203. doi: 10.1016/j.bbmt.2018.09.022. Epub 2018 Sep 22.
95 Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer.Oral Oncol. 2011 Nov;47(11):1011-6. doi: 10.1016/j.oraloncology.2011.07.012. Epub 2011 Aug 12.
96 Identification of genes and molecular pathways involved in the progression of premalignant oral epithelia.Mol Cancer Ther. 2005 Jun;4(6):865-75. doi: 10.1158/1535-7163.MCT-05-0033.
97 Infection with specific Helicobacter pylori-cag pathogenicity island strains is associated with interleukin-1B gene polymorphisms in Venezuelan chronic gastritis patients.Dig Dis Sci. 2011 Feb;56(2):449-56. doi: 10.1007/s10620-010-1316-0. Epub 2010 Jun 29.
98 Expression analysis of ST3GAL4 transcripts in cervical cancer cells.Mol Med Rep. 2018 Jul;18(1):617-621. doi: 10.3892/mmr.2018.8938. Epub 2018 Apr 27.
99 Possible role of Stat5a in rat mammary gland carcinogenesis.Breast Cancer Res Treat. 2004 Dec;88(3):263-72. doi: 10.1007/s10549-004-0805-2.
100 Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions.Oncol Lett. 2018 Sep;16(3):3833-3841. doi: 10.3892/ol.2018.9104. Epub 2018 Jul 6.
101 Induction of tolerance to immunogenic tumor antigens associated with lymphomagenesis in HOX11 transgenic mice.Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13300-5. doi: 10.1073/pnas.240221297.
102 Clinical significance of gelsolin-like actin-capping protein expression in oral carcinogenesis: an immunohistochemical study of premalignant and malignant lesions of the oral cavity.BMC Cancer. 2008 Feb 1;8:39. doi: 10.1186/1471-2407-8-39.
103 Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors.Biochem Biophys Res Commun. 2001 Jul 13;285(2):400-8. doi: 10.1006/bbrc.2001.5165.
104 Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398.Neoplasia. 2003 Mar-Apr;5(2):121-7. doi: 10.1016/s1476-5586(03)80003-9.
105 Cytoplasmic Localization of Proline, Glutamic Acid, Leucine-rich Protein 1 (PELP1) Induces Breast Epithelial Cell Migration through Up-regulation of Inhibitor of B Kinase and Inflammatory Cross-talk with Macrophages.J Biol Chem. 2017 Jan 6;292(1):339-350. doi: 10.1074/jbc.M116.739847. Epub 2016 Nov 23.
106 Molecular profiling of CD3-CD4+ T cells from patients with the lymphocytic variant of hypereosinophilic syndrome reveals targeting of growth control pathways.Blood. 2009 Oct 1;114(14):2969-83. doi: 10.1182/blood-2008-08-175091. Epub 2009 Jul 16.
107 Identification of the deleted in split hand/split foot 1 protein as a novel biomarker for human cervical cancer.Carcinogenesis. 2013 Jan;34(1):68-78. doi: 10.1093/carcin/bgs279. Epub 2012 Sep 28.
108 Estrogen-mediated signaling is differentially affected by the expression levels of Sfrp1 in mammary epithelial cells.Cell Biol Int. 2015 Jul;39(7):873-9. doi: 10.1002/cbin.10468. Epub 2015 May 5.
109 SLURP-1 is mutated in Mal de Meleda, a potential molecular signature for melanoma and a putative squamous lineage tumor suppressor gene.Int J Dermatol. 2018 Feb;57(2):162-170. doi: 10.1111/ijd.13850. Epub 2017 Dec 12.