Details of Disease | DrugMAP

General Information of Disease (ID: DIST826V)

Disease Name	Transient neonatal diabetes mellitus
Synonyms	chromosome 6-associated transient diabetes mellitus; diabetes mellitus, 6q24-related transient neonatal; diabetes mellitus, transient neonatal; transient neonatal diabetes mellitus (disease); transient neonatal diabetes mellitus; TNDM
Definition	Transient neonatal diabetes mellitus (TNDM) is a genetically heterogeneous form of neonatal diabetes (NDM) characterized by hyperglycemia presenting in the neonatal period that remits during infancy but recurs in later life in most patients.
Disease Hierarchy	DISFHF9K: Neonatal diabetes mellitus DIST826V: Transient neonatal diabetes mellitus
Disease Identifiers	MONDO ID MONDO_0020525 UMLS CUI C0342273 MedGen ID 449530 HPO ID HP:0008255 SNOMED CT ID 237603002

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 9 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ZFP57	OT5SOYAK	Strong	Autosomal recessive	[1]
KCNJ11	OTPUUELV	Supportive	Autosomal dominant	[4]
PLAGL1	OTZAO900	Supportive	Autosomal dominant	[5]
ABCC8	OTCWQ54I	Strong	Autosomal dominant	[1]
GATA4	OTQHWAZG	Strong	Autosomal dominant	[1]
GCK	OTR3Q0NN	Strong	Autosomal recessive	[1]
HNF1B	OTSYIC3T	Strong	Autosomal dominant	[1]
INS	OTZ85PDU	Strong	Autosomal dominant	[1]
SLC2A2	OTBL2W7R	Strong	Autosomal recessive	[1]
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⏷ Show the Full List of 9 DOT(s)

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
INS	TTZOPHG	Limited	Biomarker	[2]
ABCC8	TTP835K	Strong	Genetic Variation	[3]
GATA4	TT1VDN2	Strong	Autosomal dominant	[1]
GCK	TTDLNGZ	Strong	Autosomal recessive	[1]
INS	TTZOPHG	Strong	Autosomal dominant	[1]
KCNJ11	TT329V4	Strong	Genetic Variation	[3]
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⏷ Show the Full List of 6 DTT(s)

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
KCNJ11	DTGZICY	Supportive	Autosomal dominant	[4]
ABCC8	DTI58LU	Strong	Autosomal dominant	[1]
SLC2A2	DTUJPOL	Strong	Autosomal recessive	[1]
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References

1	The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources. Genet Med. 2022 Aug;24(8):1732-1742. doi: 10.1016/j.gim.2022.04.017. Epub 2022 May 4.
2	Differentiating Transient Idiopathic Hyperglycaemia and Neonatal Diabetes Mellitus in Preterm Infants.Horm Res Paediatr. 2015;84(1):68-72. doi: 10.1159/000381621. Epub 2015 May 12.
3	Minimal incidence of neonatal/infancy onset diabetes in Italy is 1:90,000 live births.Acta Diabetol. 2012 Oct;49(5):405-8. doi: 10.1007/s00592-011-0331-8. Epub 2011 Sep 28.
4	Review on monogenic diabetes. Curr Opin Endocrinol Diabetes Obes. 2011 Aug;18(4):252-8. doi: 10.1097/MED.0b013e3283488275.
5	Diabetes Mellitus, 6q24-Related Transient Neonatal. 2005 Oct 10 [updated 2018 Sep 13]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews(?) [Internet]. Seattle (WA): University of Washington, Seattle; 1993C2024.