Details of Disease

General Information of Disease (ID: DISUR9Q5)

Disease Name	Complex partial seizure
Synonyms	Complex partial epileptic seizure; psychomotor epilepsy; epilepsy, psychomotor
Disease Class	8A61-8A6Z: Epilepsy/seizure
Definition	A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and automatism may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)
Disease Hierarchy	DIS4LY5L: Focal epilepsy DISUR9Q5: Complex partial seizure
ICD Code	ICD-11 ICD-11: 8A68.0 ICD-9 ICD-9: 345.4 Expand ICD-11 '8A68.0 Expand ICD-9 345.4
Disease Identifiers	MONDO ID MONDO_0006710 MESH ID D017029 UMLS CUI C0085417 MedGen ID 43169 SNOMED CT ID 361123003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Brivaracetam	DMSEPK8	Approved	Small molecular drug	[1]
Cenobamate	DM8KLU9	Approved	NA	[2]
Ethotoin	DMXWOCP	Approved	Small molecular drug	[3]
Gabapentin	DM6T924	Approved	Small molecular drug	[4]
Ganaxolone	DMXJMKF	Approved	Small molecular drug	[5]
Vigabatrin	DMYT0OG	Approved	Small molecular drug	[6]
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⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SCN3A	TTAXZ0K	Strong	Biomarker	[7]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC4A10	DT7RYVF	Limited	Biomarker	[8]
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References

1	2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7183).
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5483).
5	ClinicalTrials.gov (NCT01963208) Phase 3 Study of Adjunctive Ganaxolone in Adults With Drug-resistant Partial Onset Seizures and Open-label Extension. U.S. National Institutes of Health.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4821).
7	Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy. Neurosci Lett. 2008 Mar 5;433(1):65-70. doi: 10.1016/j.neulet.2007.12.064. Epub 2008 Jan 11.
8	Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.Arch Neurol. 2008 Apr;65(4):550-3. doi: 10.1001/archneur.65.4.550.