Details of Disease

Disease Name

Esophageal candidiasis

esophageal thrush; esophageal moniliasis; candidiasis of the oesophagus; candidiasis of the esophagus; candidal esophagitis; Candida esophagitis

Definition

Esophagitis resulting from Candida.

Disease Hierarchy

DISOOKGO: Fungal esophagitis

DISIRYMU: Candidiasis

DISV4PM2: Esophageal candidiasis

Disease Identifiers

MONDO ID

MONDO_0001648

UMLS CUI

C0239295

MedGen ID

66784

HPO ID

HP:0033351

SNOMED CT ID

20639004

General Information of Disease (ID: DISV4PM2)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Anidulafungin	DM8QM5U	Approved	Small molecular drug	[2]
Caspofungin	DMGQIPT	Approved	Small molecular drug	[3]
Fluconazole	DMOWZ6B	Approved	Small molecular drug	[4]
Itraconazole	DMCR1MV	Approved	Small molecular drug	[5]
Micafungin	DM6Y3AN	Approved	Small molecular drug	[6]
Voriconazole	DMAOL2S	Approved	Small molecular drug	[7]
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⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DEFB4A	TTIVY12	Strong	Altered Expression	[8]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ADGRV1	OTLVXHHP	Strong	Genetic Variation	[9]
DEFB103B	OT8RWY64	Strong	Altered Expression	[8]
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References

1	Amphotericin B FDA Label
2	Anidulafungin FDA Label
3	Caspofungin FDA Label
4	Fluconazole FDA Label
5	Itraconazole FDA Label
6	Micafungin FDA Label
7	Voriconazole FDA Label
8	IL-1 and ADAM17 are central regulators of -defensin expression in Candida esophagitis.Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G547-53. doi: 10.1152/ajpgi.00251.2010. Epub 2011 Jan 13.
9	What is the clinical significance of esophagogastric junction outflow obstruction? evaluation of 60 patients at a tertiary referral center.Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13061. Epub 2017 Apr 9.