Details of Disease

General Information of Disease (ID: DISVC72D)

• Disease Name: Pityriasis rubra pilaris
• Definition: A group of skin conditions that cause constant inflammation and scaling of the skin. People with PRP have reddish, scaly patches that may occur everywhere on the body, or only on certain areas. Some people with PRP also develop thickened skin on the underside of the hands and feet (palmoplantar keratoderma), various nail abnormalities, and/or thinning of the hair. There are several types of PRP classified by age when symptoms begin, body areas involved, and whether other conditions are present. This condition occurs in adults (adult onset PRP) as well as children (juvenile onset PRP).
• Disease Hierarchy:
  DISAFOQN: Exanthem
  DISQGG08: Erythrokeratoderma
  DISVC72D: Pityriasis rubra pilaris
• Disease Identifiers:
  MONDO ID: MONDO_0100017
  MESH ID: D010916
  UMLS CUI: C0032027
  OMIM ID: 173200
  MedGen ID: 45939
  Orphanet ID: 2897
  SNOMED CT ID: 3755001

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PRNP	TTY5F9C	Definitive	Biomarker	[1]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CARD14	OTADQHOV	Limited	Genetic Variation	[2]
CNMD	OTHND8EL	Strong	Biomarker	[3]
CNTN3	OTC1274J	Strong	Biomarker	[4]
IL36RN	OT5CO95A	Strong	Genetic Variation	[5]

References

• [1] Choroidal structural changes correlate with severity of diabetic retinopathy in diabetes mellitus.BMC Ophthalmol. 2019 Aug 16;19(1):186. doi: 10.1186/s12886-019-1189-8.
• [2] The management and genetic background of pityriasis rubra pilaris: a single-centre experience.J Eur Acad Dermatol Venereol. 2019 May;33(5):944-949. doi: 10.1111/jdv.15455. Epub 2019 Mar 3.
• [3] Platelet-rich plasma induces post-natal maturation of immature articular cartilage and correlates with LOXL1 activation.Sci Rep. 2017 Jun 16;7(1):3699. doi: 10.1038/s41598-017-02297-9.
• [4] Comparison of mental and physical health between patients with primary and secondary Raynaud's phenomenon Category: Article.J Psychosom Res. 2019 Jan;116:6-9. doi: 10.1016/j.jpsychores.2018.11.001. Epub 2018 Nov 5.
• [5] Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin.J Dermatol Sci. 2018 May;90(2):105-111. doi: 10.1016/j.jdermsci.2018.01.012. Epub 2018 Feb 1.