Details of Disease

Disease Name

exanthem; Rash; exanthem (disease); cutaneous eruption; skin Rash; exanthema; skin eruption

Definition

Any change in the skin which affects its appearance or texture. A rash may be localized to one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful.

Disease Hierarchy

DIS9YPUQ: Dermatological disease

DISAFOQN: Exanthem

Disease Identifiers

MONDO ID

MONDO_0006547

MESH ID

D005076

UMLS CUI

C0015230

MedGen ID

8732

HPO ID

HP:4000054

General Information of Disease (ID: DISAFOQN)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 25 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Alclometasone	DMAE84F	Approved	Small molecular drug	[1]
Amcinonide	DMM1JL9	Approved	Small molecular drug	[2]
Ammonium lactate	DMXMHBB	Approved	Small molecular drug	[3]
Benzoyl peroxide	DMSTW1Q	Approved	Small molecular drug	[4]
Betamethasone	DMAHJEF	Approved	Small molecular drug	[5]
Clocortolone	DM9ZMQH	Approved	Small molecular drug	[6]
Cortisone Acetate	DMG8K57	Approved	Small molecular drug	[7]
Desonide	DMTP2NJ	Approved	Small molecular drug	[8]
Desoximetasone	DM4PXF6	Approved	Small molecular drug	[9]
Dexamethasone	DMMWZET	Approved	Small molecular drug	[10]
Diflorasone	DMI9PRJ	Approved	Small molecular drug	[11]
Flumethasone	DMUNG4A	Approved	NA	[12]
Fluocinolone Acetonide	DMG2KI4	Approved	Small molecular drug	[13]
Fluocinonide	DM65KL8	Approved	Small molecular drug	[14]
Flurandrenolide	DMHCI9S	Approved	Small molecular drug	[15]
Fluticasone propionate	DMRWLB2	Approved	NA	[16]
Halcinonide	DMGLAX1	Approved	Small molecular drug	[17]
Hydrocortisone	DMGEMB7	Approved	Small molecular drug	[18]
Methylprednisolone	DM4BDON	Approved	Small molecular drug	[19]
Mometasone	DM45OJN	Approved	Small molecular drug	[20]
Pramoxine	DMZ2LGD	Approved	Small molecular drug	[21]
Prednicarbate	DMBUNVW	Approved	Small molecular drug	[22]
Prednisolone	DMQ8FR2	Approved	Small molecular drug	[23]
Triamcinolone	DM98IXF	Approved	Small molecular drug	[24]
Urea	DMUK75B	Approved	Small molecular drug	[25]
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⏷ Show the Full List of 25 Drug(s)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
IDP-122	DM3A701	Phase 3	NA	[26]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 18 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
APOA1	TT5S8DR	Limited	Biomarker	[27]
PTH1R	TTFPD47	Limited	Genetic Variation	[28]
TNFRSF11A	TT3K9S2	Limited	Altered Expression	[29]
TNFRSF8	TT2GM5R	Limited	Biomarker	[30]
CCR4	TT7HQD0	Disputed	Genetic Variation	[31]
ABCB11	TTUXCAF	Strong	Genetic Variation	[32]
CFP	TTLA0VS	Strong	Biomarker	[33]
CPA1	TT3LJ6G	Strong	Biomarker	[34]
CTLA4	TTI2S1D	Strong	Biomarker	[35]
GJA1	TT4F7SL	Strong	Biomarker	[36]
IL1RL2	TTUS18T	Strong	Genetic Variation	[37]
IL1RN	TT6GSR3	Strong	Therapeutic	[38]
MVK	TT5DFHW	Strong	Biomarker	[39]
NLRP3	TT4EN8X	Strong	Genetic Variation	[40]
NOD2	TTYPUHA	Strong	Genetic Variation	[41]
PGRMC1	TTY3LAZ	Strong	Biomarker	[42]
RUNX2	TTD6SZ8	Strong	Genetic Variation	[43]
TIRAP	TTKU0LS	Strong	Biomarker	[44]
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⏷ Show the Full List of 18 DTT(s)

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
GPT	DER5HFI	Limited	Biomarker	[45]
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This Disease Is Related to 27 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ADNP	OTEGICWR	Limited	Biomarker	[46]
CARD14	OTADQHOV	Limited	Biomarker	[47]
CKB	OTUCKOTT	Limited	Biomarker	[48]
FAM20A	OT5Z5IW8	Limited	Biomarker	[49]
C1QA	OT6XKVVA	moderate	Biomarker	[27]
A1BG	OTFVUGNQ	Strong	Biomarker	[50]
ADAM11	OTPTVW5W	Strong	Biomarker	[51]
AMBN	OTWASIMQ	Strong	Biomarker	[52]
ARID4B	OTYLPILE	Strong	Biomarker	[53]
ASPN	OTYJM80N	Strong	Biomarker	[54]
CSTA	OT1K68KE	Strong	Biomarker	[55]
DIRAS3	OT3XHLQA	Strong	Altered Expression	[56]
DLX4	OTLWVCN4	Strong	Biomarker	[57]
DSG1	OT11HC3A	Strong	Biomarker	[58]
ENOSF1	OT65D3ZK	Strong	Genetic Variation	[59]
GNLY	OTZJKA8C	Strong	Biomarker	[60]
LDHB	OT9B1CT3	Strong	Biomarker	[61]
NAE1	OTMC6F3Y	Strong	Biomarker	[62]
NPHS1	OT21JD3P	Strong	Genetic Variation	[63]
ODAM	OTT666SJ	Strong	Altered Expression	[64]
PIK3R1	OT5BZ1J9	Strong	Genetic Variation	[65]
RECQL4	OT59LSW7	Strong	Genetic Variation	[59]
RHOH	OT1J9SEB	Strong	Biomarker	[66]
SAE1	OT18HFX5	Strong	Biomarker	[67]
SDHB	OTRE1M1T	Strong	Genetic Variation	[68]
SERPINB4	OT88LHZ8	Strong	Altered Expression	[69]
SPRTN	OT01D5CE	Strong	Genetic Variation	[70]
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⏷ Show the Full List of 27 DOT(s)

References

1	Alclometasone FDA Label
2	Amcinonide FDA Label
3	Ammonium lactate FDA Label
4	Benzoyl peroxide FDA Label
5	Betamethasone FDA Label
6	Clocortolone FDA Label
7	Cortisone acetate FDA Label
8	Desonide FDA Label
9	Desoximetasone FDA Label
10	Dexamethasone FDA Label
11	Diflorasone FDA Label
12	Flumethasone FDA Label
13	Fluocinolone acetonide FDA Label
14	Fluocinonide FDA Label
15	Flurandrenolide FDA Label
16	Fluticasone propionate FDA Label
17	Halcinonide FDA Label
18	Hydrocortisone FDA Label
19	Methylprednisolone FDA Label
20	Mometasone FDA Label
21	Pramoxine FDA Label
22	Prednicarbate FDA Label
23	Prednisolone FDA Label
24	Triamcinolone FDA Label
25	Urea FDA Label
26	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
27	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
28	A novel nonsense PTH1R variant shows incomplete penetrance of primary failure of eruption: a case report.BMC Oral Health. 2019 Nov 15;19(1):249. doi: 10.1186/s12903-019-0944-9.
29	Abnormal bone remodelling activity of dental follicle cells from a cleidocranial dysplasia patient.Oral Dis. 2018 Oct;24(7):1270-1281. doi: 10.1111/odi.12900. Epub 2018 Jun 8.
30	Disseminated CD8-positive, CD30-positive cutaneous lymphoproliferative eruption with overlapping features of mycosis fungoides and primary cutaneous anaplastic large cell lymphoma following remote solitary lesional presentation.J Cutan Pathol. 2017 Aug;44(8):703-712. doi: 10.1111/cup.12961. Epub 2017 Jun 13.
31	Mogamulizumab for the Treatment of Adult T-cell Leukemia/Lymphoma.Clin Lymphoma Myeloma Leuk. 2019 Jun;19(6):326-331. doi: 10.1016/j.clml.2019.03.004. Epub 2019 Mar 23.
32	Diagnosis of BSEP/ABCB11 mutations in Asian patients with cholestasis using denaturing high performance liquid chromatography.J Pediatr. 2008 Dec;153(6):825-32. doi: 10.1016/j.jpeds.2008.06.034. Epub 2008 Aug 9.
33	The Application of T.SPOT-TB Assay for Early Diagnosis of Active Tuberculosis in Chronic Kidney Disease Patients Receiving Immunosuppressive Treatment.J Invest Surg. 2020 Oct;33(9):853-858. doi: 10.1080/08941939.2019.1566417. Epub 2019 Mar 27.
34	Chikungunya virus infection in Aruba: Diagnosis, clinical features and predictors of post-chikungunya chronic polyarthralgia.PLoS One. 2018 Apr 30;13(4):e0196630. doi: 10.1371/journal.pone.0196630. eCollection 2018.
35	Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events.J Transl Med. 2013 Mar 22;11:75. doi: 10.1186/1479-5876-11-75.
36	Gene expression profiles in dental follicles from patients with impacted canines.Odontology. 2018 Oct;106(4):351-359. doi: 10.1007/s10266-018-0342-9. Epub 2018 Feb 12.
37	IL36RN mutation causing generalized pustular psoriasis in a Palestinian patient.Int J Dermatol. 2014 Jul;53(7):866-8. doi: 10.1111/ijd.12525. Epub 2014 Jun 5.
38	Beneficial response to anakinra and thalidomide in Schnitzler's syndrome.Ann Rheum Dis. 2006 Apr;65(4):542-4. doi: 10.1136/ard.2005.045245. Epub 2005 Aug 11.
39	Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome.Nat Genet. 1999 Jun;22(2):175-7. doi: 10.1038/9691.
40	Nlrp3: an immune sensor of cellular stress and infection.Int J Biochem Cell Biol. 2010 Jun;42(6):792-5. doi: 10.1016/j.biocel.2010.01.008. Epub 2010 Jan 13.
41	Early diagnosis of early-onset sarcoidosis: a case report with functional analysis and review of the literature.Clin Rheumatol. 2017 May;36(5):1189-1196. doi: 10.1007/s10067-017-3544-6. Epub 2017 Jan 27.
42	Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1.Breast Cancer Res. 2008;10(5):R85. doi: 10.1186/bcr2155. Epub 2008 Oct 15.
43	RUNX2 mutation impairs osteogenic differentiation of dental follicle cells.Arch Oral Biol. 2019 Jan;97:156-164. doi: 10.1016/j.archoralbio.2018.10.029. Epub 2018 Oct 29.
44	Association of TLR4 (D299G, T399I), TLR9 -1486T>C, TIRAP S180L and TNF- promoter (-1031, -863, -857) polymorphisms with risk for systemic lupus erythematosus among South Indians.Lupus. 2015 Jan;24(1):50-7. doi: 10.1177/0961203314549792. Epub 2014 Sep 2.
45	Vincristine and sirolimus in the treatment of kaposiform haemangioendothelioma.J Paediatr Child Health. 2019 Sep;55(9):1119-1124. doi: 10.1111/jpc.14370. Epub 2019 Jan 2.
46	Premature primary tooth eruption in cognitive/motor-delayed ADNP-mutated children.Transl Psychiatry. 2017 Feb 21;7(2):e1043. doi: 10.1038/tp.2017.27.
47	Histopathologic findings characteristic of CARD14-associated papulosquamous eruption.J Cutan Pathol. 2020 May;47(5):425-430. doi: 10.1111/cup.13633. Epub 2019 Dec 26.
48	Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer.Cancer Res. 2006 Jan 15;66(2):763-9. doi: 10.1158/0008-5472.CAN-05-3771.
49	FAM20A mutations associated with enamel renal syndrome.J Dent Res. 2014 Jan;93(1):42-8. doi: 10.1177/0022034513512653. Epub 2013 Nov 6.
50	Outcomes of 44 Consecutive Complete Bilateral Cleft Lip and Palate Patients Treated With Secondary Alveolar Bone Grafting and Premaxillary Osteotomy.Cleft Palate Craniofac J. 2017 May;54(3):249-255. doi: 10.1597/15-162. Epub 2016 Mar 31.
51	Up-regulation of CCL17, CCL22 and CCR4 in drug-induced maculopapular exanthema.Clin Exp Allergy. 2007 May;37(5):704-13. doi: 10.1111/j.1365-2222.2007.02699.x.
52	Genetic analysis of familial non-syndromic primary failure of eruption.Orthod Craniofac Res. 2009 May;12(2):74-81. doi: 10.1111/j.1601-6343.2009.01440.x.
53	Maple Syrup Urine Disease Complicated with Kyphoscoliosis and Myelopathy.Pediatr Neonatol. 2016 Oct;57(5):431-435. doi: 10.1016/j.pedneo.2013.10.013. Epub 2014 Jan 30.
54	Periodontal ligament-associated protein-1 gets involved in the development of osseous eruption canal.J Mol Histol. 2019 Feb;50(1):35-42. doi: 10.1007/s10735-018-9805-0. Epub 2018 Dec 3.
55	Mental health effects following the eruption in Eyjafjallajkull volcano in Iceland: A population-based study.Scand J Public Health. 2019 Mar;47(2):251-259. doi: 10.1177/1403494817751327. Epub 2018 Jan 9.
56	NOEY2 mutations in primary breast cancers and breast hyperplasia.Breast. 2009 Jun;18(3):197-203. doi: 10.1016/j.breast.2009.04.004. Epub 2009 May 30.
57	Long-term efficacy and safety of lamotrigine for all types of bipolar disorder.Neuropsychiatr Dis Treat. 2017 Mar 20;13:843-854. doi: 10.2147/NDT.S128653. eCollection 2017.
58	Desmoglein1 Deficiency Is a Potential Cause of Cutaneous Eruptions Induced by Shuanghuanglian Injection.Molecules. 2018 Jun 19;23(6):1477. doi: 10.3390/molecules23061477.
59	Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome.Hum Mol Genet. 2005 Mar 15;14(6):813-25. doi: 10.1093/hmg/ddi075. Epub 2005 Feb 9.
60	Clinicopathologic analysis of atypical hand, foot, and mouth disease in adult patients.J Am Acad Dermatol. 2017 Apr;76(4):722-729. doi: 10.1016/j.jaad.2016.10.022. Epub 2016 Dec 24.
61	Comparative analysis of inflamed and non-inflamed colon biopsies reveals strong proteomic inflammation profile in patients with ulcerative colitis.BMC Gastroenterol. 2012 Jun 24;12:76. doi: 10.1186/1471-230X-12-76.
62	An evaluation of single nucleotide polymorphisms used to differentiate vaccine and wild type strains of varicella-zoster virus.J Med Virol. 2005 Jan;75(1):174-80. doi: 10.1002/jmv.20253.
63	Genotype/phenotype correlations of NPHS1 and NPHS2 mutations in nephrotic syndrome advocate a functional inter-relationship in glomerular filtration. Hum Mol Genet. 2002 Feb 15;11(4):379-88. doi: 10.1093/hmg/11.4.379.
64	Expression of odontogenic ameloblast-associated protein in the dental follicle and its role in osteogenic differentiation of dental follicle stem cells.Arch Oral Biol. 2017 Jun;78:6-12. doi: 10.1016/j.archoralbio.2017.02.001. Epub 2017 Feb 5.
65	High-throughput screening identified inherited genetic variations in the EGFR pathway contributing to skin toxicity of EGFR inhibitors.Pharmacogenomics. 2015;16(14):1605-19. doi: 10.2217/pgs.15.97. Epub 2015 Sep 30.
66	EGFR pathway biomarkers in erlotinib-treated patients with advanced pancreatic cancer: translational results from the randomised, crossover phase 3 trial AIO-PK0104.Br J Cancer. 2013 Feb 5;108(2):469-76. doi: 10.1038/bjc.2012.495. Epub 2012 Nov 20.
67	Association Between Autoantibody Phenotype and Cutaneous Adverse Reactions to Hydroxychloroquine in Dermatomyositis.JAMA Dermatol. 2018 Oct 1;154(10):1199-1203. doi: 10.1001/jamadermatol.2018.2549.
68	Novel germline mutations in the SDHB and SDHD genes in Japanese pheochromocytomas.Horm Res. 2007;68(2):68-71. doi: 10.1159/000099655. Epub 2007 Feb 15.
69	Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients.Allergol Int. 2018 Jan;67(1):124-130. doi: 10.1016/j.alit.2017.06.016. Epub 2017 Jul 19.
70	Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model.Chem Res Toxicol. 2020 Jan 21;33(1):211-222. doi: 10.1021/acs.chemrestox.9b00247. Epub 2019 Oct 9.