Details of Disease

General Information of Disease (ID: DISVFLRK)

• Disease Name: Nematode infection
• Synonyms: Disease due to Nematoda; nematode infection; Infections, Nematode; Nematode infection; Nematodiasis; nematodiasis; Nematode Infection; Infection, Nematode; Nematode Infections; Nematoda disease or disorder; disease due to nematoda; Nematoda caused disease or disorder
• Disease Class: 1F60-1F69: Nematode infection
• Definition: Infections caused by nematode larvae which never develop into the adult stage and migrate through various body tissues. They commonly infect the skin, eyes, and viscera in humans. Ancylostoma brasiliensis causes cutaneous larva migrans. Toxocara causes visceral larva migrans.
• Disease Hierarchy:
  DIS7CGKY: Helminth infection
  DISEM33Q: Infectious disease
  DISVFLRK: Nematode infection
• ICD Code: ICD-11: ICD-11: 1F60-1F69
• Disease Identifiers:
  MONDO ID: MONDO_0005871
  UMLS CUI: C0027583
  MedGen ID: 45025
  SNOMED CT ID: 84706005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
KSI-4088	DM4EF1K	Investigative	NA	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PPOX	TTNFMS9	Limited	Altered Expression	[2]
IL4	TTLGTKB	Strong	Biomarker	[3]
IL4R	TTDWHC3	Strong	Biomarker	[4]
TNFRSF1A	TTG043C	Strong	Biomarker	[5]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP1A1	DE6OQ3W	Strong	Biomarker	[6]

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AIP	OTDJ3OSV	Limited	Biomarker	[7]
PRSS22	OTANEFGM	Limited	Altered Expression	[8]
RIOX2	OT2YFPI2	Limited	Biomarker	[9]
RNPC3	OTW5MKC1	Limited	Biomarker	[10]
TRIT1	OTCU9FS5	Limited	Biomarker	[11]
MUC2	OT3X4QVX	Strong	Biomarker	[12]
MUC4	OTLT11V1	Strong	Biomarker	[12]
RETNLB	OT9JJQQQ	Strong	Altered Expression	[13]

References

• [1] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [2] The prophenoloxidase system in Drosophila participates in the anti-nematode immune response.Mol Immunol. 2019 May;109:88-98. doi: 10.1016/j.molimm.2019.03.008. Epub 2019 Mar 22.
• [3] Changes of cytokine mRNA expression and IgG responses in rats infected with Capillaria hepatica.Korean J Parasitol. 2007 Jun;45(2):95-102. doi: 10.3347/kjp.2007.45.2.95.
• [4] Ym1 induces RELM and rescues IL-4R deficiency in lung repair during nematode infection.PLoS Pathog. 2018 Nov 30;14(11):e1007423. doi: 10.1371/journal.ppat.1007423. eCollection 2018 Nov.
• [5] An atherogenic lipid profile with low serum paraoxonase-1 activity during nematode infection in rats.Eur J Clin Invest. 2010 Nov;40(11):984-93. doi: 10.1111/j.1365-2362.2010.02352.x.
• [6] Infection of rats with Taenia taeniformis metacestodes increases hepatic CYP450, induces the activity of CYP1A1, CYP2B1 and COH isoforms and increases the genotoxicity of the procarcinogens benzo[a]pyrene, cyclophosphamide and aflatoxin B(1).Mutagenesis. 2003 Mar;18(2):211-6. doi: 10.1093/mutage/18.2.211.
• [7] Purification and cloning of an apoptosis-inducing protein derived from fish infected with Anisakis simplex, a causative nematode of human anisakiasis.J Immunol. 2000 Aug 1;165(3):1491-7. doi: 10.4049/jimmunol.165.3.1491.
• [8] Differential expression of genes in fetal brain as a consequence of maternal protein deficiency and nematode infection.Int J Parasitol. 2018 Jan;48(1):51-58. doi: 10.1016/j.ijpara.2017.07.005. Epub 2017 Sep 10.
• [9] Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway.PLoS One. 2019 Feb 26;14(2):e0211244. doi: 10.1371/journal.pone.0211244. eCollection 2019.
• [10] Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms.J Vis Exp. 2018 May 25;(135):57350. doi: 10.3791/57350.
• [11] The modified base isopentenyladenosine and its derivatives in tRNA.RNA Biol. 2017 Sep 2;14(9):1197-1208. doi: 10.1080/15476286.2017.1294309. Epub 2017 Feb 17.
• [12] Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat.APMIS. 2006 Apr;114(4):270-8. doi: 10.1111/j.1600-0463.2006.apm_353.x.
• [13] A Novel Non-invasive Method to Detect RELM Beta Transcript in Gut Barrier Related Changes During a Gastrointestinal Nematode Infection.Front Immunol. 2019 Mar 12;10:445. doi: 10.3389/fimmu.2019.00445. eCollection 2019.