Details of Disease

General Information of Disease (ID: DISVVH6I)

Disease Name Hemiplegia
Synonyms postnatal infantile hemiplegia; infantile hemiplegia
Definition
Severe or complete loss of motor function on one side of the body. This condition is usually caused by brain diseases that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, brain stem lesions; cervical spinal cord diseases; peripheral nervous system diseases; and other conditions may manifest as hemiplegia. The term hemiparesis (see paresis) refers to mild to moderate weakness involving one side of the body.
Disease Hierarchy
DISH9EST: Palsy
DISVVH6I: Hemiplegia
Disease Identifiers
MONDO ID
MONDO_0001170
MESH ID
D006429
UMLS CUI
C0018991
MedGen ID
9196
HPO ID
HP:0002301
SNOMED CT ID
50582007

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 4 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
SCN1A TTANOZH moderate Genetic Variation [1]
CACNA1A TTX4QDJ Strong Biomarker [2]
CGA TTFC29G Strong Biomarker [3]
SLC1A3 TT8WRDA Strong Genetic Variation [4]
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This Disease Is Related to 3 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ATP1A3 OTM8EG6H Strong Genetic Variation [5]
HNRNPU OTLQN1E2 Strong Genetic Variation [6]
PRSS21 OT8ZYC7G Strong Biomarker [7]
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References

1 Neuroimaging and neuropathology of Dravet syndrome.Epilepsia. 2011 Apr;52 Suppl 2:30-4. doi: 10.1111/j.1528-1167.2011.02998.x.
2 Familial Hemiplegic Migraine With Progressive Cerebellar Ataxia Caused by a p.Thr666Met CACNA1A Gene Mutation in a Chinese Family.Front Neurol. 2019 Nov 19;10:1221. doi: 10.3389/fneur.2019.01221. eCollection 2019.
3 Hemiplegia after thyrotropin alfa in a hypothyroid patient with thyroid carcinoma metastatic to the brain.J Clin Endocrinol Metab. 1999 Nov;84(11):3867-71. doi: 10.1210/jcem.84.11.6161.
4 Episodic ataxia associated with EAAT1 mutation C186S affecting glutamate reuptake. Arch Neurol. 2009 Jan;66(1):97-101. doi: 10.1001/archneurol.2008.535.
5 Cognitive deficits caused by a disease-mutation in the 3 Na(+)/K(+)-ATPase isoform.Sci Rep. 2016 Aug 23;6:31972. doi: 10.1038/srep31972.
6 An episode of acute encephalopathy with biphasic seizures and late reduced diffusion followed by hemiplegia and intractable epilepsy observed in a patient with a novel frameshift mutation in HNRNPU.Brain Dev. 2018 Oct;40(9):813-818. doi: 10.1016/j.braindev.2018.05.010. Epub 2018 May 29.
7 Echocardiography-guided aortic cannulation by the Seldinger technique for type A dissection with cerebral malperfusion.J Thorac Cardiovasc Surg. 2020 Mar;159(3):784-793. doi: 10.1016/j.jtcvs.2019.02.097. Epub 2019 Mar 13.