Details of Disease

General Information of Disease (ID: DISY8WKT)

Disease Name Trophoblastic neoplasm
Synonyms
tumour of trophoblast; tumor of trophoblast; trophoblastic tumour (qualifier value); trophoblastic tumour; trophoblastic tumor (qualifier value); trophoblastic tumor; trophoblastic neoplasms; trophoblastic neoplasm NOS (morphologic abnormality); trophoblastic neoplasm (morphologic abnormality); trophoblastic neoplasm; trophoblast tumour; trophoblast tumor; trophoblast neoplasm (disease); trophoblast neoplasm; neoplasm of trophoblast
Definition A gestational or non-gestational neoplasm composed of neoplastic trophoblastic cells. Representative examples include hydatidiform mole and choriocarcinoma.
Disease Hierarchy
DISTBY9Z: Tumour
DISY8WKT: Trophoblastic neoplasm
Disease Identifiers
MONDO ID
MONDO_0002872
MESH ID
D014328
UMLS CUI
C0041182
MedGen ID
21708
HPO ID
HP:0031502
SNOMED CT ID
115234004

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
HSD3B1 DERDQWN moderate Biomarker [1]
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This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CITED1 OTUJQ3VL Strong Altered Expression [2]
GH2 OT32TR4C Strong Altered Expression [3]
RASA2 OTL06RG2 Strong Altered Expression [4]
SALL1 OTYYZGLH Strong Altered Expression [5]
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References

1 HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions.Am J Surg Pathol. 2008 Feb;32(2):236-42. doi: 10.1097/PAS.0b013e31812e0046.
2 Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling.Cell Death Dis. 2018 Sep 11;9(9):924. doi: 10.1038/s41419-018-0991-1.
3 Detection of placental growth hormone variant and chorionic somatomammotropin ribonucleic acid expression in human trophoblastic neoplasms by reverse transcriptase-polymerase chain reaction.Endocrinology. 1994 Jun;134(6):2461-7. doi: 10.1210/endo.134.6.7515000.
4 The role of ras GTPase activating protein in human tumorigenesis.Pathobiology. 1995;63(6):348-50. doi: 10.1159/000163971.
5 SALL1 expression in the human pituitary-adrenal/gonadal axis.J Endocrinol. 2002 Jun;173(3):437-48. doi: 10.1677/joe.0.1730437.