Details of Disease

General Information of Disease (ID: DIS6ZC3X)

Disease Name	Brain disease
Synonyms	encephalopathy; disorder of brain; disease of brain; disease or disorder of brain; brain disease; brain disease or disorder
Disease Class	8C70-8E61: Brain disease
Definition	A disease affecting the brain or part of the brain.\|Editor note: NCIT has different classes for brain disease and encephalopathy
Disease Hierarchy	DISEP2HK: Central and peripheral nervous disease DISWD40R: Disease DIS6ZC3X: Brain disease
ICD Code	ICD-11 ICD-11: 8C70-8E61 ICD-10 ICD-10: G00-G99
Disease Identifiers	MONDO ID MONDO_0005560 MESH ID D001927 UMLS CUI C0006111 MedGen ID 14214 SNOMED CT ID 81308009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Dacarbazine	DMNPZL4	Approved	Small molecular drug	[1]
Dasatinib	DMJV2EK	Approved	Small molecular drug	[2]
Gadoteridol	DMRGSKK	Approved	Small molecular drug	[3]
Iodamide	DM8FOMA	Approved	Small molecular drug	[3]
Iomeprol	DMRPPF5	Approved	Small molecular drug	[3]
Pramiracetam	DM2FHG3	Approved (orphan drug)	Small molecular drug	[3]
Temozolomide	DMKECZD	Approved	Small molecular drug	[4]
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⏷ Show the Full List of 7 Drug(s)

This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
99mTc-tropantiol	DMH81QG	Phase 2/3	NA	[5]
11C-PBR-28	DMSLMY7	Phase 2	NA	[6]
BAY-85-8102	DMOUVE7	Phase 1	NA	[7]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BC-19	DM8MFS6	Investigative	NA	[8]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 55 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ALB	TTFNGC9	Limited	Biomarker	[9]
KCNQ2	TTPXI3S	Limited	Biomarker	[10]
MPO	TTVCZPI	Limited	Biomarker	[11]
OGG1	TTRU01G	Limited	Biomarker	[12]
OTC	TT5KIO9	Limited	Biomarker	[13]
SLC1A1	TTG2A6F	Limited	Biomarker	[14]
SLC6A5	TTI0138	Limited	Biomarker	[15]
TH	TTUHP71	Limited	Therapeutic	[16]
TYMS	TTP1UKZ	Limited	Biomarker	[17]
CDK5	TTL4Q97	moderate	Altered Expression	[18]
GRIN2B	TTN9D8E	moderate	Biomarker	[19]
SLC1A3	TT8WRDA	moderate	Biomarker	[20]
SV2A	TTT3P91	moderate	Biomarker	[21]
TSPO	TTPTXIN	moderate	Biomarker	[22]
ABCA4	TTLB52K	Strong	Genetic Variation	[23]
ABCC9	TTEF5MJ	Strong	Genetic Variation	[24]
ADAMTS4	TTYG6BU	Strong	Biomarker	[25]
APEH	TTYWEDQ	Strong	Biomarker	[26]
APP	TTE4KHA	Strong	Biomarker	[27]
C9orf72	TTA4SHR	Strong	Biomarker	[28]
CDK5R1	TTBYM6V	Strong	Biomarker	[29]
COASY	TT4YO0Z	Strong	Biomarker	[30]
CYP46A1	TT4EB85	Strong	Biomarker	[31]
DPYSL2	TTZCW3T	Strong	Altered Expression	[32]
FDPS	TTIKWV4	Strong	Biomarker	[33]
FES	TTLBY21	Strong	Biomarker	[33]
FGF14	TTKJX1V	Strong	Biomarker	[34]
GAP43	TTSGLN5	Strong	Biomarker	[35]
GBA	TT1B5PU	Strong	Biomarker	[36]
GIP	TT40HS5	Strong	Biomarker	[37]
GPR17	TTMPART	Strong	Biomarker	[38]
GRIN2A	TTKJEMQ	Strong	Biomarker	[39]
GRM2	TTXJ47W	Strong	Biomarker	[40]
GRN	TT0LWE3	Strong	Biomarker	[41]
HCRT	TTU5HJP	Strong	Altered Expression	[42]
HTR4	TT07C3Y	Strong	Altered Expression	[43]
HTT	TTIWZ0O	Strong	Biomarker	[44]
IDS	TTNY2AP	Strong	Biomarker	[45]
IFNB1	TT4TZ8J	Strong	Biomarker	[46]
MAPK10	TT056SO	Strong	Genetic Variation	[47]
NR4A2	TT9HKN3	Strong	Biomarker	[48]
P2RX7	TT473XN	Strong	Biomarker	[49]
PDE9A	TTZOEBC	Strong	Biomarker	[50]
PDF	TT9SL3Q	Strong	Biomarker	[51]
PREP	TTNGKET	Strong	Biomarker	[52]
RTN4R	TTVRZUO	Strong	Biomarker	[53]
S100B	TTQ0V86	Strong	Biomarker	[54]
SCN2A	TTLJTUF	Strong	Biomarker	[55]
SLC12A1	TTS087L	Strong	Biomarker	[56]
SLC22A8	TTTQR47	Strong	Biomarker	[57]
SLC5A4	TTN7Y4P	Strong	Biomarker	[58]
SLC6A3	TTVBI8W	Strong	Biomarker	[59]
SNCA	TT08OSU	Strong	Biomarker	[60]
TARDBP	TT9RZ03	Strong	Biomarker	[61]
CYP2A6	TTAQ6ZW	Definitive	Biomarker	[62]
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⏷ Show the Full List of 55 DTT(s)

This Disease Is Related to 6 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
CACNG2	DTRL7OG	Strong	Biomarker	[63]
KCNK2	DTENHUP	Strong	Altered Expression	[64]
SLC12A2	DTHKL3Q	Strong	Biomarker	[65]
SLC30A3	DTKMECW	Strong	Altered Expression	[66]
SLC9A6	DTN0JXW	Strong	Genetic Variation	[67]
SLC9A9	DT8LP62	Strong	Genetic Variation	[67]
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⏷ Show the Full List of 6 DTP(s)

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
MAT1A	DEQ6NC9	Strong	Biomarker	[68]
QARS1	DEVSTRI	Strong	Genetic Variation	[69]
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This Disease Is Related to 74 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CP	OTM8JE4Y	Limited	Biomarker	[70]
RBFOX3	OTL0F3D6	Limited	Genetic Variation	[71]
SCO1	OTC45UGB	Limited	Biomarker	[72]
TJP1	OTBDCUPK	Limited	Biomarker	[73]
TSC2	OT47LWI9	Limited	Biomarker	[74]
AQP4	OTA9MYD5	moderate	Biomarker	[75]
CALML6	OTHVPDSD	moderate	Genetic Variation	[76]
CETN1	OTGQ8JOZ	moderate	Genetic Variation	[76]
DISC1	OT43AW4H	moderate	Biomarker	[77]
ABCG4	OT2XJIOG	Strong	Biomarker	[78]
ACTL6B	OTO7EJIS	Strong	Biomarker	[79]
ADAMTS2	OTTK22NO	Strong	Biomarker	[25]
ASTN1	OT23FQIB	Strong	Genetic Variation	[80]
ATP6V0D1	OT9GU2NW	Strong	Biomarker	[29]
CDK5R2	OTNUTLPU	Strong	Biomarker	[29]
CLN5	OTY265P6	Strong	Biomarker	[81]
CTC1	OTRJY7QD	Strong	Biomarker	[82]
CYFIP1	OTOBEH24	Strong	Biomarker	[83]
CYFIP2	OTCAY35T	Strong	Biomarker	[83]
DLX1	OT7BH057	Strong	Biomarker	[84]
DLX2	OTKC2DQ0	Strong	Altered Expression	[84]
DSCAM	OTL7PRMK	Strong	Altered Expression	[85]
EFHD2	OTM9VMN3	Strong	Biomarker	[86]
EIF2B1	OT4NCVY1	Strong	Genetic Variation	[87]
EIF2B2	OTQQMHM1	Strong	Genetic Variation	[87]
EIF2B4	OTTM5SX1	Strong	Genetic Variation	[87]
EIF2S2	OTXF0B09	Strong	Genetic Variation	[87]
FUT8	OTJJCVG1	Strong	Biomarker	[88]
GCHFR	OTEOT8GI	Strong	Biomarker	[29]
IBTK	OTB2GM4G	Strong	Biomarker	[89]
ILF2	OTWWVM9X	Strong	Biomarker	[90]
KDM4B	OT5P1UPY	Strong	Biomarker	[91]
KIRREL2	OTSLTR4Y	Strong	Altered Expression	[92]
LAMC3	OTKNAYJO	Strong	Biomarker	[93]
LAT	OTZC1XZ1	Strong	Genetic Variation	[94]
LRRC4C	OT5QI5EP	Strong	Biomarker	[95]
LRSAM1	OTOKWR6C	Strong	Biomarker	[96]
MPEG1	OT7DAO0F	Strong	Genetic Variation	[97]
NALCN	OTWY7DS0	Strong	Biomarker	[98]
NCAM2	OT8LBJN8	Strong	Altered Expression	[99]
NCAN	OT8OO6ZE	Strong	Biomarker	[100]
NDN	OTYBYJ82	Strong	Altered Expression	[101]
NLGN3	OTKDEC1Q	Strong	Genetic Variation	[102]
NLGN4X	OTDJGBK8	Strong	Biomarker	[102]
NOS1AP	OTDFOBRU	Strong	Biomarker	[103]
NRF1	OTOXWNV8	Strong	Biomarker	[104]
NRXN1	OTJN1JQA	Strong	Genetic Variation	[105]
NUBP1	OTE8RAKZ	Strong	Biomarker	[30]
OPN4	OT1LZ7TS	Strong	Biomarker	[106]
ORM2	OTRJGZP8	Strong	Biomarker	[107]
PCDH19	OTSOW3MV	Strong	Genetic Variation	[108]
PDCD10	OTCHJTSF	Strong	Genetic Variation	[109]
PIK3R2	OTZSUQK5	Strong	Genetic Variation	[110]
POMT1	OTGQSHL5	Strong	Altered Expression	[111]
PRRX2	OT8UR4AU	Strong	Biomarker	[112]
RPP25	OTEN6QN7	Strong	Biomarker	[113]
RPS27	OTFXKY7P	Strong	Genetic Variation	[97]
SARS1	OTFKXQ1O	Strong	Biomarker	[114]
SARS2	OTU4T99W	Strong	Biomarker	[114]
SERPINI1	OTUJHIJW	Strong	Genetic Variation	[109]
SPAST	OTIF3AJI	Strong	Genetic Variation	[115]
SRCIN1	OTQZNQQ5	Strong	Altered Expression	[116]
SRPX2	OT6A63TX	Strong	Genetic Variation	[117]
SYNGAP1	OT41HVYQ	Strong	Biomarker	[118]
TAAR6	OTUBUJ2N	Strong	Biomarker	[119]
TAFA1	OT1V0THS	Strong	Biomarker	[120]
TAS1R3	OTOVM44D	Strong	Biomarker	[58]
TMEM106B	OTUWA6NW	Strong	Genetic Variation	[121]
TREX1	OTQG7K12	Strong	Genetic Variation	[122]
TRIOBP	OTGB5WHC	Strong	Genetic Variation	[123]
TSC1	OTFF4YZ7	Strong	Biomarker	[74]
RNASET2	OTWY64L7	Definitive	Biomarker	[124]
STAMBP	OTOT2OXM	Definitive	Biomarker	[125]
TSPOAP1	OTAM8SGF	Definitive	Biomarker	[126]
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⏷ Show the Full List of 74 DOT(s)

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