Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DE5WGIM)

DME Name	Aminoglycoside phosphotransferase (aph-Ib)
Synonyms	Campylobacter jejuni aminoglycoside phosphotransferase; 2''-aminoglycoside phosphotransferase; Aph(2'')-Ib
Gene Name	aph(2'')-Ib
UniProt ID	A0A075C7U3_CAMJU
INTEDE ID	DME1090
EC Number	EC: 2.7.1.190 Transferase Kinase Phosphotransferase EC: 2.7.1.190
Lineage	Species: Campylobacter jejuni Kingdom: Bacteria Phylum: Proteobacteria Class: Epsilonproteobacteria Order: Campylobacterales Family: Campylobacteraceae Genus: Campylobacter Species: Campylobacter jejuni
Tissue Distribution	Primarily distributed in human gut.
Sequence	MIDLDVEIYQHLNEQIKINKLCYLSSGDDSDTFLCNEQYVVKVPKRDSVRFAQKREFELY RFLENCNLSYQTPAVVYQSDRFNIMKYIKGERITYEQYHKLSEKEKDALAYDEATFLKEL HSIEIDCSVSLFSDALVNKKDKFLQDKKLLISILEKEQLLTDEMLEHIETIYENISSNAV IFNYIPCLVHNDFSANNLIFRNNRLFGVIDFGDFNVGDPDNDFLCLLDCSTDDFGKEFGR KVLKYYQHKAPEVAERKAELNDVYWSIDQIIYGYERKDREMLIKGVSELLQTQAEMFIF
Function	This enzyme is the most clinically important aminoglycoside-modifying enzyme in Gram-positive bacteria, responsible for high-level resistance in both Enterococci and Staphylococci. And this bacterial enzyme phosphorylates many 4,6-disubstituted aminoglycoside antibiotics that have a hydroxyl group at position 2'', including kanamycin A, kanamycin B, tobramycin, dibekacin, arbekacin, amikacin, gentamicin C, sisomicin and netilmicin.

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

5 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[1]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[1]
Sisomicin	DM92P0F	N. A.	N. A.	Approved	[2]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[1]
Dibekacin	DMTX0PZ	N. A.	N. A.	Phase 4	[2]
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References

1	Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17.
2	Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen. Antimicrob Agents Chemother. 2013 Jan;57(1):452-7.