Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DE5WGIM)

• DME Name: Aminoglycoside phosphotransferase (aph-Ib) DME Info
• Gene Name: aph(2'')-Ib

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[1]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[1]
Sisomicin	DM92P0F	N. A.	N. A.	Approved	[2]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[1]
Dibekacin	DMTX0PZ	N. A.	N. A.	Phase 4	[2]

References

• [1] Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17.
• [2] Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen. Antimicrob Agents Chemother. 2013 Jan;57(1):452-7.