Details of Drug-Metabolizing Enzyme (DME)

General Information of Drug-Metabolizing Enzyme (DME) (ID: DECV2ME)

DME Name	Cytochrome P450 105D7 (cyp105)
Synonyms	Cytochrome P450 family 105 subfamily D member 7; Pentalenic acid synthase; SAV_7469; cyp105d7; cyp28
Gene Name	cyp28
UniProt ID	CYP28_STRAW
INTEDE ID	DME1233
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	EC: 1.14.15.11 Oxidoreductase Oxygen paired donor oxidoreductase Iron-sulfur protein donor oxidoreductase EC: 1.14.15.11
Lineage	Species: Streptomyces avermitilis Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Streptomycetales Family: Streptomycetaceae Genus: Streptomyces Species: Streptomyces avermitilis
Tissue Distribution	Primarily distributed in human gut.
Sequence	MTEPGTSVSAPVAFPQDRTCPYDPPTAYDPLREGRPLSRVSLYDGRSVWVVTGHAAARAL LSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGVDDPEHRTQRRMLVPSFTLKRAAALR PRIQETVDGLLDAMEAQGPPAELVSAFALPLPSMVICALLGVPYADHDFFESQSRRLLRG PGIAEVQDARAQLDDYLYALIDRKRKEPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLI AGHETTANMISLGTFTLLRHPEQLAELRAEPGLMPAAVEELLRFLSIADGLLRVATEDIE VAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHRSARHHVAFGFGIHQCLGQNLARAE MEIALGTLFERLPGLRLAAPADEIPFKPGDTIQGMLELPVTW
Function	This enzyme is a P-450 heme-thiolate protein, and it catalyzes the conversion of 1-deoxypentalenic acid to pentalenic acid in the biosynthesis of neopentalenolactone antibiotic.
KEGG Pathway	( ) ( )

Molecular Interaction Atlas (MIA) of This DME

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DME

1 Approved Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac	DMPIHLS	Osteoarthritis	FA00-FA05	Approved	[1], [2]
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1 Clinical Trial Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Naringenin	DMHAZLM	N. A.	N. A.	Phase 1	[1], [2]
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1 Discontinued Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mevastatin	DM1LGKP	N. A.	N. A.	Terminated	[1], [2]
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1 Investigative Drug(s) Metabolized by This DME

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Q-27137207	DML5KMT	Discovery agent	N.A.	Investigative	[1], [2]
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Experimental Enzyme Kinetic Data of Drugs

Drug Name	Indication	Highest Status	Kinetic Data	REF
Mevastatin	N. A.	Terminated	Km = 39.1 microM	[1], [2]
Diclofenac	Osteoarthritis [FA00-FA05]	Approved	Kcat/Km = 0.15 s-1microM-1	[1], [2]

References

1	The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
2	Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.