General Information of Drug Off-Target (DOT) (ID: OT1BLFJO)

DOT Name Histone H2B type 1-B (H2BC3)
Synonyms H2B-clustered histone 3; Histone H2B.1; Histone H2B.f; H2B/f
Gene Name H2BC3
UniProt ID
H2B1B_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
3X1S; 3X1U
Pfam ID
PF00125
Sequence
MPEPSKSAPAPKKGSKKAITKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
KEGG Pathway
Neutrophil extracellular trap formation (hsa04613 )
Alcoholism (hsa05034 )
Viral carcinogenesis (hsa05203 )
Systemic lupus erythematosus (hsa05322 )
Reactome Pathway
Cleavage of the damaged pyrimidine (R-HSA-110329 )
Recognition and association of DNA glycosylase with site containing an affected purine (R-HSA-110330 )
Cleavage of the damaged purine (R-HSA-110331 )
Meiotic synapsis (R-HSA-1221632 )
Packaging Of Telomere Ends (R-HSA-171306 )
Pre-NOTCH Transcription and Translation (R-HSA-1912408 )
Formation of the beta-catenin (R-HSA-201722 )
PRC2 methylates histones and DNA (R-HSA-212300 )
Condensation of Prophase Chromosomes (R-HSA-2299718 )
Oxidative Stress Induced Senescence (R-HSA-2559580 )
Senescence-Associated Secretory Phenotype (SASP) (R-HSA-2559582 )
DNA Damage/Telomere Stress Induced Senescence (R-HSA-2559586 )
HDACs deacetylate histones (R-HSA-3214815 )
HATs acetylate histones (R-HSA-3214847 )
SIRT1 negatively regulates rRNA expression (R-HSA-427359 )
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (R-HSA-427389 )
NoRC negatively regulates rRNA expression (R-HSA-427413 )
B-WICH complex positively regulates rRNA expression (R-HSA-5250924 )
DNA methylation (R-HSA-5334118 )
Transcriptional regulation by small RNAs (R-HSA-5578749 )
Activation of anterior HOX genes in hindbrain development during early embryogenesis (R-HSA-5617472 )
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886 )
Ub-specific processing proteases (R-HSA-5689880 )
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (R-HSA-5693565 )
Nonhomologous End-Joining (NHEJ) (R-HSA-5693571 )
Processing of DNA double-strand break ends (R-HSA-5693607 )
Deposition of new CENPA-containing nucleosomes at the centromere (R-HSA-606279 )
Assembly of the ORC complex at the origin of replication (R-HSA-68616 )
G2/M DNA damage checkpoint (R-HSA-69473 )
RNA Polymerase I Promoter Opening (R-HSA-73728 )
RNA Polymerase I Promoter Escape (R-HSA-73772 )
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654 )
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (R-HSA-8936459 )
RUNX1 regulates transcription of genes involved in differentiation of HSCs (R-HSA-8939236 )
Estrogen-dependent gene expression (R-HSA-9018519 )
Meiotic recombination (R-HSA-912446 )
HCMV Early Events (R-HSA-9609690 )
HCMV Late Events (R-HSA-9610379 )
Transcriptional regulation of granulopoiesis (R-HSA-9616222 )
Inhibition of DNA recombination at telomere (R-HSA-9670095 )
Defective pyroptosis (R-HSA-9710421 )
Amyloid fiber formation (R-HSA-977225 )
Chromatin modifications during the maternal to zygotic transition (MZT) (R-HSA-9821002 )
Replacement of protamines by nucleosomes in the male pronucleus (R-HSA-9821993 )
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (R-HSA-110328 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
14 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Acetaminophen decreases the expression of Histone H2B type 1-B (H2BC3). [1]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of Histone H2B type 1-B (H2BC3). [2]
Cisplatin DMRHGI9 Approved Cisplatin decreases the expression of Histone H2B type 1-B (H2BC3). [3]
Hydrogen peroxide DM1NG5W Approved Hydrogen peroxide affects the expression of Histone H2B type 1-B (H2BC3). [4]
Methotrexate DM2TEOL Approved Methotrexate decreases the expression of Histone H2B type 1-B (H2BC3). [5]
Menadione DMSJDTY Approved Menadione affects the expression of Histone H2B type 1-B (H2BC3). [4]
Demecolcine DMCZQGK Approved Demecolcine increases the expression of Histone H2B type 1-B (H2BC3). [6]
Dasatinib DMJV2EK Approved Dasatinib decreases the expression of Histone H2B type 1-B (H2BC3). [7]
Bicalutamide DMZMSPF Approved Bicalutamide increases the expression of Histone H2B type 1-B (H2BC3). [8]
Urethane DM7NSI0 Phase 4 Urethane decreases the expression of Histone H2B type 1-B (H2BC3). [9]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the expression of Histone H2B type 1-B (H2BC3). [11]
Formaldehyde DM7Q6M0 Investigative Formaldehyde increases the expression of Histone H2B type 1-B (H2BC3). [6]
Deguelin DMXT7WG Investigative Deguelin increases the expression of Histone H2B type 1-B (H2BC3). [12]
Paraquat DMR8O3X Investigative Paraquat decreases the expression of Histone H2B type 1-B (H2BC3). [13]
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⏷ Show the Full List of 14 Drug(s)
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of Histone H2B type 1-B (H2BC3). [10]
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References

1 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
2 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
3 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
4 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
5 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
6 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
7 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
8 Casodex treatment induces hypoxia-related gene expression in the LNCaP prostate cancer progression model. BMC Urol. 2005 Mar 24;5:5.
9 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
10 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
11 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
12 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
13 An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat. Toxicol In Vitro. 2022 Jun;81:105333. doi: 10.1016/j.tiv.2022.105333. Epub 2022 Feb 16.