General Information of Drug Off-Target (DOT) (ID: OT3BAB16)

DOT Name Histone H2A type 1-D (H2AC7)
Synonyms Histone H2A.3; Histone H2A/g
Gene Name H2AC7
UniProt ID
H2A1D_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
5GT3; 6KBB; 7EA8; 7WLP; 8H1T
Pfam ID
PF00125 ; PF16211
Sequence
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
KEGG Pathway
ATP-dependent chromatin remodeling (hsa03082 )
Necroptosis (hsa04217 )
Neutrophil extracellular trap formation (hsa04613 )
Alcoholism (hsa05034 )
Systemic lupus erythematosus (hsa05322 )
Reactome Pathway
Cleavage of the damaged pyrimidine (R-HSA-110329 )
Recognition and association of DNA glycosylase with site containing an affected purine (R-HSA-110330 )
Cleavage of the damaged purine (R-HSA-110331 )
Meiotic synapsis (R-HSA-1221632 )
Packaging Of Telomere Ends (R-HSA-171306 )
Pre-NOTCH Transcription and Translation (R-HSA-1912408 )
Formation of the beta-catenin (R-HSA-201722 )
PRC2 methylates histones and DNA (R-HSA-212300 )
Condensation of Prophase Chromosomes (R-HSA-2299718 )
Oxidative Stress Induced Senescence (R-HSA-2559580 )
Senescence-Associated Secretory Phenotype (SASP) (R-HSA-2559582 )
DNA Damage/Telomere Stress Induced Senescence (R-HSA-2559586 )
HDACs deacetylate histones (R-HSA-3214815 )
HATs acetylate histones (R-HSA-3214847 )
RMTs methylate histone arginines (R-HSA-3214858 )
SIRT1 negatively regulates rRNA expression (R-HSA-427359 )
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (R-HSA-427389 )
NoRC negatively regulates rRNA expression (R-HSA-427413 )
B-WICH complex positively regulates rRNA expression (R-HSA-5250924 )
DNA methylation (R-HSA-5334118 )
Transcriptional regulation by small RNAs (R-HSA-5578749 )
Activation of anterior HOX genes in hindbrain development during early embryogenesis (R-HSA-5617472 )
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886 )
UCH proteinases (R-HSA-5689603 )
Ub-specific processing proteases (R-HSA-5689880 )
Metalloprotease DUBs (R-HSA-5689901 )
Deposition of new CENPA-containing nucleosomes at the centromere (R-HSA-606279 )
Assembly of the ORC complex at the origin of replication (R-HSA-68616 )
RNA Polymerase I Promoter Opening (R-HSA-73728 )
RNA Polymerase I Promoter Escape (R-HSA-73772 )
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (R-HSA-8936459 )
RUNX1 regulates transcription of genes involved in differentiation of HSCs (R-HSA-8939236 )
Estrogen-dependent gene expression (R-HSA-9018519 )
Meiotic recombination (R-HSA-912446 )
HCMV Early Events (R-HSA-9609690 )
HCMV Late Events (R-HSA-9610379 )
Transcriptional regulation of granulopoiesis (R-HSA-9616222 )
Inhibition of DNA recombination at telomere (R-HSA-9670095 )
Defective pyroptosis (R-HSA-9710421 )
Amyloid fiber formation (R-HSA-977225 )
Chromatin modifications during the maternal to zygotic transition (MZT) (R-HSA-9821002 )
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (R-HSA-110328 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
9 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Acetaminophen increases the expression of Histone H2A type 1-D (H2AC7). [1]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of Histone H2A type 1-D (H2AC7). [2]
Cisplatin DMRHGI9 Approved Cisplatin increases the expression of Histone H2A type 1-D (H2AC7). [3]
Menadione DMSJDTY Approved Menadione affects the expression of Histone H2A type 1-D (H2AC7). [4]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the expression of Histone H2A type 1-D (H2AC7). [5]
(+)-JQ1 DM1CZSJ Phase 1 (+)-JQ1 increases the expression of Histone H2A type 1-D (H2AC7). [6]
PMID28460551-Compound-2 DM4DOUB Patented PMID28460551-Compound-2 decreases the expression of Histone H2A type 1-D (H2AC7). [7]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the expression of Histone H2A type 1-D (H2AC7). [8]
Milchsaure DM462BT Investigative Milchsaure increases the expression of Histone H2A type 1-D (H2AC7). [9]
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⏷ Show the Full List of 9 Drug(s)

References

1 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
2 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
3 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
4 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
5 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
6 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
7 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
8 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
9 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.