Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT4IPNZC)

• DOT Name: Adhesion G-protein coupled receptor G7 (ADGRG7)
• Synonyms: G-protein coupled receptor 128
• Gene Name: ADGRG7
• Related Disease:
  Hepatocellular carcinoma
  Adult lymphoma
  Androgen insensitivity syndrome
  Lymphoma
  Pediatric lymphoma
  Thyroid tumor
• UniProt ID: AGRG7_HUMAN
• Pfam ID: PF00002 ; PF01825
• Sequence:
  MASCRAWNLRVLVAVVCGLLTGIILGLGIWRIVIRIQRGKSTSSSSTPTEFCRNGGTWEN
  GRCICTEEWKGLRCTIANFCENSTYMGFTFARIPVGRYGPSLQTCGKDTPNAGNPMAVRL
  CSLSLYGEIELQKVTIGNCNENLETLEKQVKDVTAPLNNISSEVQILTSDANKLTAENIT
  SATRVVGQIFNTSRNASPEAKKVAIVTVSQLLDASEDAFQRVAATANDDALTTLIEQMET
  YSLSLGNQSVVEPNIAIQSANFSSENAVGPSNVRFSVQKGASSSLVSSSTFIHTNVDGLN
  PDAQTELQVLLNMTKNYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDENEQDQS
  ASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAV
  LMTFKKDYQYPKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLI
  FNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVT
  FTWNALSAAQLYYLLIRTMKPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWE
  LDYRQEKICWLAIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTS
  TKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQGLQIFILY
  TVRTKVFQSEASKVLMLLSSIGRRKSLPSVTRPRLRVKMYNFLRSLPTLHERFRLLETSP
  STEEITLSESDNAKESI
• Function: Orphan receptor.

Molecular Interaction Atlas (MIA) of This DOT

6 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Hepatocellular carcinoma	DIS0J828	Definitive	Biomarker	[1]
Adult lymphoma	DISK8IZR	Strong	Biomarker	[2]
Androgen insensitivity syndrome	DISUZBBO	Strong	Altered Expression	[3]
Lymphoma	DISN6V4S	Strong	Biomarker	[2]
Pediatric lymphoma	DIS51BK2	Strong	Biomarker	[2]
Thyroid tumor	DISLVKMD	Strong	Altered Expression	[2]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate decreases the methylation of Adhesion G-protein coupled receptor G7 (ADGRG7).	[4]

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the expression of Adhesion G-protein coupled receptor G7 (ADGRG7).	[5]
QUERCITRIN	DM1DH96	Investigative	QUERCITRIN increases the expression of Adhesion G-protein coupled receptor G7 (ADGRG7).	[6]

References

• [1] Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
• [2] TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals.Haematologica. 2010 Jan;95(1):20-6. doi: 10.3324/haematol.2009.011536. Epub 2009 Oct 1.
• [3] The 17-estradiol induced upregulation of the adhesion G-protein coupled receptor (ADGRG7) is modulated by ESR and SP1 complex.Biol Open. 2019 Jan 14;8(1):bio037390. doi: 10.1242/bio.037390.
• [4] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [5] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [6] Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.