Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT4WC3OQ)

DOT Name Selenocysteine lyase (SCLY)
Synonyms hSCL; EC 4.4.1.16
Gene Name SCLY
UniProt ID
SCLY_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
PDB ID
3GZC; 3GZD
EC Number
4.4.1.16
Pfam ID
PF00266
Sequence
MEAAVAPGRDAPAPAASQPSGCGKHNSPERKVYMDYNATTPLEPEVIQAMTKAMWEAWGN
PSSPYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSVVKHFHANQTS
KGHTGGHHSPVKGAKPHFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKVSGQAEVDDI
LAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKALNQERVAAGLPPILVHTDAAQALGK
QRVDVEDLGVDFLTIVGHKFYGPRIGALYIRGLGEFTPLYPMLFGGGQERNFRPGTENTP
MIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFGQKRIHLNSQFPGTQRLPNTCN
FSIRGPRLQGHVVLAQCRVLMASVGAACHSDHGDQPSPVLLSYGVPFDVARNALRLSVGR
STTRAEVDLVVQDLKQAVAQLEDQA
Function Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.
KEGG Pathway
Selenocompound metabolism (hsa00450 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Metabolism of ingested SeMet, Sec, MeSec into H2Se (R-HSA-2408508 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Selenocysteine lyase (SCLY). [1]
------------------------------------------------------------------------------------
8 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Ciclosporin DMAZJFX Approved Ciclosporin decreases the expression of Selenocysteine lyase (SCLY). [2]
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Selenocysteine lyase (SCLY). [3]
Acetaminophen DMUIE76 Approved Acetaminophen decreases the expression of Selenocysteine lyase (SCLY). [4]
Cisplatin DMRHGI9 Approved Cisplatin decreases the expression of Selenocysteine lyase (SCLY). [5]
Hydrogen peroxide DM1NG5W Approved Hydrogen peroxide affects the expression of Selenocysteine lyase (SCLY). [6]
Demecolcine DMCZQGK Approved Demecolcine decreases the expression of Selenocysteine lyase (SCLY). [7]
GSK2110183 DMZHB37 Phase 2 GSK2110183 decreases the expression of Selenocysteine lyase (SCLY). [8]
Formaldehyde DM7Q6M0 Investigative Formaldehyde decreases the expression of Selenocysteine lyase (SCLY). [7]
------------------------------------------------------------------------------------
⏷ Show the Full List of 8 Drug(s)

References

1 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
2 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
3 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
4 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
5 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
6 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
7 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
8 Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.