Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT5B6EU8)

• DOT Name: Ester hydrolase C11orf54 (C11ORF54)
• Synonyms: EC 3.1.-.-
• Gene Name: C11ORF54
• UniProt ID: CK054_HUMAN
• PDB ID: 1XCR
• EC Number: 3.1.-.-
• Pfam ID: PF08925
• Sequence:
  MACAEFSFHVPSLEELAGVMQKGLKDNFADVQVSVVDCPDLTKEPFTFPVKGICGKTRIA
  EVGGVPYLLPLVNQKKVYDLNKIAKEIKLPGAFILGAGAGPFQTLGFNSEFMPVIQTESE
  HKPPVNGSYFAHVNPADGGCLLEKYSEKCHDFQCALLANLFASEGQPGKVIEVKAKRRTG
  PLNFVTCMRETLEKHYGNKPIGMGGTFIIQKGKVKSHIMPAEFSSCPLNSDEEVNKWLHF
  YEMKAPLVCLPVFVSRDPGFDLRLEHTHFFSRHGEGGHYHYDTTPDIVEYLGYFLPAEFL
  YRIDQPKETHSIGRD
• Function: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.

Molecular Interaction Atlas (MIA) of This DOT

14 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate decreases the expression of Ester hydrolase C11orf54 (C11ORF54).	[1]
Ciclosporin	DMAZJFX	Approved	Ciclosporin decreases the expression of Ester hydrolase C11orf54 (C11ORF54).	[2]
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Ester hydrolase C11orf54 (C11ORF54).	[3]
Cisplatin	DMRHGI9	Approved	Cisplatin increases the expression of Ester hydrolase C11orf54 (C11ORF54).	[4]
Ivermectin	DMDBX5F	Approved	Ivermectin decreases the expression of Ester hydrolase C11orf54 (C11ORF54).	[5]
Quercetin	DM3NC4M	Approved	Quercetin decreases the expression of Ester hydrolase C11orf54 (C11ORF54).	[6]
Arsenic trioxide	DM61TA4	Approved	Arsenic trioxide decreases the expression of Ester hydrolase C11orf54 (C11ORF54).	[7]
Hydrogen peroxide	DM1NG5W	Approved	Hydrogen peroxide decreases the expression of Ester hydrolase C11orf54 (C11ORF54).	[8]
Calcitriol	DM8ZVJ7	Approved	Calcitriol increases the expression of Ester hydrolase C11orf54 (C11ORF54).	[9]
Vitamin C	DMXJ7O8	Approved	Vitamin C decreases the expression of Ester hydrolase C11orf54 (C11ORF54).	[7]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the expression of Ester hydrolase C11orf54 (C11ORF54).	[10]
PMID28460551-Compound-2	DM4DOUB	Patented	PMID28460551-Compound-2 increases the expression of Ester hydrolase C11orf54 (C11ORF54).	[11]
Formaldehyde	DM7Q6M0	Investigative	Formaldehyde decreases the expression of Ester hydrolase C11orf54 (C11ORF54).	[13]
Milchsaure	DM462BT	Investigative	Milchsaure decreases the expression of Ester hydrolase C11orf54 (C11ORF54).	[14]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A increases the methylation of Ester hydrolase C11orf54 (C11ORF54).	[12]

References

• [1] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [2] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [3] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [4] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [5] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [6] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [7] Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.
• [8] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [9] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [10] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [11] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [12] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [13] Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
• [14] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.