Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OT7VJXAT)

DOT Name Fanconi anemia core complex-associated protein 100 (FAAP100)
Synonyms Fanconi anemia-associated protein of 100 kDa
Gene Name FAAP100
Related Disease
Fanconi anemia complementation group A ( )
Fanconi's anemia ( )
UniProt ID
FP100_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
7KZP; 7KZQ; 7KZR; 7KZS; 7KZT; 7KZV
Pfam ID
PF15146
Sequence
MAGAAPRVRYLAGFCCPLGGLAAGKPRVLCHEAEVFLSTGSELVYVYDQEGGLLTAAFRF
PDQVWHLELLAPRRLLYALCARRGLYCLSLDHPGRSRSTSQDDRDSEDGDQPSPVIPVDP
DACILPDAALCAFTLLDSVLVTLVQGPARWKMQLFEQPCPGEDPRPGGQIGEVELSSYTP
PAGVPGKPAAPHFLPVLCSVSPSGSRVPHDLLGGSGGFTLEDALFGLLFGADATLLQSPV
VLCGLPDGQLCCVILKALVTSRSAPGDPNALVKILHHLEEPVIFIGALKTEPQAAEAAEN
FLPDEDVHCDCLVAFGHHGRMLAIKASWDESGKLVPELREYCLPGPVLCAACGGGGRVYH
STPSDLCVVDLSRGSTPLGPEQPEEGPGGLPPMLCPASLNICSVVSLSASPRTHEGGTKL
LALSAKGRLMTCSLDLDSEMPGPARMTTESAGQKIKELLSGIGNISERVSFLKKAVDQRN
KALTSLNEAMNVSCALLSSGTGPRPISCTTSTTWSRLQTQDVLMATCVLENSSSFSLDQG
WTLCIQVLTSSCALDLDSACSAITYTIPVDQLGPGARREVTLPLGPGENGGLDLPVTVSC
TLFYSLREVVGGALAPSDSEDPFLDECPSDVLPEQEGVCLPLSRHTVDMLQCLRFPGLAP
PHTRAPSPLGPTRDPVATFLETCREPGSQPAGPASLRAEYLPPSVASIKVSAELLRAALK
DGHSGVPLCCATLQWLLAENAAVDVVRARALSSIQGVAPDGANVHLIVREVAMTDLCPAG
PIQAVEIQVESSSLADICRAHHAVVGRMQTMVTEQATQGSSAPDLRVQYLRQIHANHETL
LREVQTLRDRLCTEDEASSCATAQRLLQVYRQLRHPSLILL
Function
Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed.
KEGG Pathway
Fanconi anemia pathway (hsa03460 )
Reactome Pathway
PKR-mediated signaling (R-HSA-9833482 )
Fanconi Anemia Pathway (R-HSA-6783310 )

Molecular Interaction Atlas (MIA) of This DOT

2 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Fanconi anemia complementation group A DIS8PZLI Strong Biomarker [1]
Fanconi's anemia DISGW6Q8 Limited Biomarker [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
3 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Fanconi anemia core complex-associated protein 100 (FAAP100). [3]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Fanconi anemia core complex-associated protein 100 (FAAP100). [8]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the methylation of Fanconi anemia core complex-associated protein 100 (FAAP100). [9]
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5 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Fanconi anemia core complex-associated protein 100 (FAAP100). [4]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate decreases the expression of Fanconi anemia core complex-associated protein 100 (FAAP100). [5]
Estradiol DMUNTE3 Approved Estradiol increases the expression of Fanconi anemia core complex-associated protein 100 (FAAP100). [6]
Temozolomide DMKECZD Approved Temozolomide increases the expression of Fanconi anemia core complex-associated protein 100 (FAAP100). [7]
Formaldehyde DM7Q6M0 Investigative Formaldehyde decreases the expression of Fanconi anemia core complex-associated protein 100 (FAAP100). [10]
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References

1 Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility.PLoS Genet. 2018 Dec 12;14(12):e1007821. doi: 10.1371/journal.pgen.1007821. eCollection 2018 Dec.
2 Structure of the Fanconi anaemia monoubiquitin ligase complex.Nature. 2019 Nov;575(7781):234-237. doi: 10.1038/s41586-019-1703-4. Epub 2019 Oct 30.
3 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
4 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
5 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
6 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
7 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
8 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
9 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
10 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.