Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTDOBD9M)

DOT Name Actin-like protein 9 (ACTL9)
Gene Name ACTL9
Related Disease
Atopic dermatitis ( )
Spermatogenic failure 53 ( )
Obsolete non-syndromic male infertility due to sperm motility disorder ( )
UniProt ID
ACTL9_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00022
Sequence
MDASRPKSSESQSSLEAPRPGPNPSPNVVNKPLQRDSPGMVADRLPPKTGAVVIDMGTGT
CKVGFAGQASPTYTVATILGCQPKKPATSGQSGLQTFIGEAARVLPELTLVQPLRSGIVV
DWDAAELIWRHLLEHDLRVATHDHPLLFSDPPFSPATNREKLVEVAFESLRSPAMYVASQ
SVLSVYAHGRVSGLVVDTGHGVTYTVPVFQGYNLLHATERLDLAGNNLTAFLAEMLLQAG
LPLGQQDLDLVENIKHHYCYVASDFQKEQARPEQEYKRTLKLPDGRTVTLGKELFQCPEL
LFNPPEVPGLSPVGLSTMAKQSLRKLSLEMRADLAQNVLLCGGSSLFTGFEGRFRAELLR
ALPAETHVVVAAQPTRNFSVWIGGSILASLRAFQSCWVLREQYEEQGPYIVYRKCY
Function Testis-specic protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.
Tissue Specificity Testis-specific.

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Atopic dermatitis DISTCP41 Strong Genetic Variation [1]
Spermatogenic failure 53 DISBKKAZ Strong Autosomal recessive [2]
Obsolete non-syndromic male infertility due to sperm motility disorder DISG7641 Supportive Autosomal recessive [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Actin-like protein 9 (ACTL9). [3]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Actin-like protein 9 (ACTL9). [4]
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References

1 Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients.Gene. 2015 Oct 25;571(2):249-51. doi: 10.1016/j.gene.2015.06.068. Epub 2015 Jun 27.
2 Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice. Am J Hum Genet. 2021 Mar 4;108(3):469-481. doi: 10.1016/j.ajhg.2021.02.004. Epub 2021 Feb 23.
3 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
4 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.