Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTHKTSA0)

DOT Name	Ras-related protein Rab-34, isoform NARR (RAB34)
Synonyms	Nine amino-acid residue-repeats
Gene Name	RAB34
Related Disease	Subarachnoid hemorrhage ( ) Advanced cancer ( ) Breast cancer ( ) Breast carcinoma ( ) Cleft lip/palate ( ) Glioma ( ) Hereditary hemochromatosis ( ) Neoplasm ( ) Polydactyly ( ) Hepatocellular carcinoma ( )
UniProt ID	NARR_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVGQPQPRDDVGSPRPRVIVGTIRPRVIVGTIRPRVIVGSARARPPPDGTPRPQLAAEES PRPRVIFGTPRARVILGSPRPRVIVSSPWPAVVVASPRPRTPVGSPWPRVVVGTPRPRVI VGSPRARVADADPASAPSQGALQGRRQDEHSGTRAEGSRPGGAAPVPEEGGRFARAQRLP PPRHLRLPGAPDRHRGQI

Molecular Interaction Atlas (MIA) of This DOT

10 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance
Subarachnoid hemorrhage	DISI7I8Y	Definitive	Biomarker	[1]
Advanced cancer	DISAT1Z9	Strong	Biomarker	[2]
Breast cancer	DIS7DPX1	Strong	Biomarker	[2]
Breast carcinoma	DIS2UE88	Strong	Biomarker	[2]
Cleft lip/palate	DIS14IG3	Strong	Genetic Variation	[3]
Glioma	DIS5RPEH	Strong	Altered Expression	[4]
Hereditary hemochromatosis	DISVG5MT	Strong	Biomarker	[5]
Neoplasm	DISZKGEW	Strong	Altered Expression	[6]
Polydactyly	DIS25BMZ	Strong	Genetic Variation	[3]
Hepatocellular carcinoma	DIS0J828	moderate	Altered Expression	[6]
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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DOT

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the methylation of Ras-related protein Rab-34, isoform NARR (RAB34).	[7]
Arsenic	DMTL2Y1	Approved	Arsenic affects the methylation of Ras-related protein Rab-34, isoform NARR (RAB34).	[9]
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2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Ivermectin	DMDBX5F	Approved	Ivermectin decreases the expression of Ras-related protein Rab-34, isoform NARR (RAB34).	[8]
Carbamazepine	DMZOLBI	Approved	Carbamazepine affects the expression of Ras-related protein Rab-34, isoform NARR (RAB34).	[10]
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References

1	Anatomical triangles defining routes to anterior communicating artery aneurysms: the junctional and precommunicating triangles and the role of dome projection.J Neurosurg. 2019 Apr 5;132(5):1517-1528. doi: 10.3171/2018.12.JNS183264.
2	Rab34 regulates adhesion, migration, and invasion of breast cancer cells.Oncogene. 2018 Jul;37(27):3698-3714. doi: 10.1038/s41388-018-0202-7. Epub 2018 Apr 6.
3	Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse.J Cell Sci. 2018 Nov 8;131(21):jcs213710. doi: 10.1242/jcs.213710.
4	RAB34 was a progression- and prognosis-associated biomarker in gliomas.Tumour Biol. 2015 Mar;36(3):1573-8. doi: 10.1007/s13277-014-2732-0. Epub 2014 Dec 13.
5	Small GTPases in hedgehog signalling: emerging insights into the disease mechanisms of Rab23-mediated and Arl13b-mediated ciliopathies.Curr Opin Genet Dev. 2019 Jun;56:61-68. doi: 10.1016/j.gde.2019.07.009. Epub 2019 Aug 27.
6	Overexpression of RAB34 correlates with poor prognosis and tumor progression in hepatocellular carcinoma.Oncol Rep. 2017 Nov;38(5):2967-2974. doi: 10.3892/or.2017.5957. Epub 2017 Sep 18.
7	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
8	Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
9	Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
10	Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.