Details of the Drug

General Information of Drug (ID: DMZOLBI)

Drug Name
Carbamazepine
Synonyms Carbamazepine (iv, epilepsy); Carbamazepine (iv, epilepsy), Lundbeck; Carbamazepine (iv, epilepsy), Ovation Pharmaceuticals
Indication
Disease Entry ICD 11 Status REF
Epilepsy 8A60-8A68 Approved [1]
Epilepsy with generalized tonic-clonic seizures N.A. Approved [2]
Focal epilepsy N.A. Approved [2]
Glossopharyngeal neuralgia N.A. Approved [2]
Trigeminal neuralgia 8B82.0 Approved [2]
Type-1 diabetes 5A10 NDA filed [3]
Gastric adenocarcinoma 2B72 Phase 3 [4]
⏷ Show the Full List of Indication(s)
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 236.27
Logarithm of the Partition Coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 1
ADMET Property
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 1.9 +/- 0.3 mg/L [5]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 19 +/- 7 h [5]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [6]
Bioavailability
The bioavailability of drug is 75-85% [5]
Clearance
The apparent oral clearance of drug is 25 +/- 5 mL/min [7]
Elimination
After an oral dose of radiolabeled carbamazepine, 72% of the administered radioactive dose was detected in the urine and the remainder of the ingested dose was found in the feces [7]
Half-life
The concentration or amount of drug in body reduced by one-half in 35 - 40 hours [7]
Metabolism
The drug is metabolized via the liver [8]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 113.00359 micromolar/kg/day [9]
Vd
The volume of distribution (Vd) of drug is 1.0 L/kg [10]
Water Solubility
The ability of drug to dissolve in water is measured as 0.256 mg/mL [6]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Drug dependence Not Available EPHX2 OTPTRCNW [11]
Nephropathy toxic Not Available GGT1 OTYDA1Z7 [11]
Porphyria Not Available hemB OT8LTBA9 [11]
Porphyria Not Available ALAD OTHM9GSH [11]
Rash macular HLA-C*08:01 HLA-C OTV38BUJ [12]
Renal impairment Not Available B2M OTDWN6NX [11]
Stevens-Johnson syndrome rs3909184 FLOT1 OT0JPPJZ [13]
⏷ Show the Full List of 7 ADR Information of This Drug
Chemical Identifiers
Formula
C15H12N2O
IUPAC Name
benzo[b][1]benzazepine-11-carboxamide
Canonical SMILES
C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
InChI
InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
InChIKey
FFGPTBGBLSHEPO-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2554
ChEBI ID
CHEBI:3387
CAS Number
298-46-4
DrugBank ID
DB00564
TTD ID
D04MSM
VARIDT ID
DR00395
INTEDE ID
DR0270
ACDINA ID
D00097
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Modulator [14]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [15]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [16]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [17]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [18]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [19]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [20]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [21]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Substrate [22]
Epoxide hydrolase 1 (EPHX1) DELB4KP HYEP_HUMAN Substrate [23]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) OTSBQR6D PLCG1_HUMAN Gene/Protein Processing [24]
14-3-3 protein beta/alpha OTGBS3RF 1433B_HUMAN Gene/Protein Processing [24]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Gene/Protein Processing [25]
14-3-3 protein theta OTWG7F3H 1433T_HUMAN Gene/Protein Processing [24]
2-hydroxyacyl-CoA lyase 1 (HACL1) OT0XBOVJ HACL1_HUMAN Gene/Protein Processing [25]
2-oxoadipate dehydrogenase complex component E1 (DHTKD1) OTDQLSNT DHTK1_HUMAN Gene/Protein Processing [25]
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA) OT0LHOZB ODBA_HUMAN Gene/Protein Processing [25]
2-phosphoxylose phosphatase 1 (PXYLP1) OTX8T7F6 PXYP1_HUMAN Gene/Protein Processing [25]
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1) OTBAJT4I CP39A_HUMAN Gene/Protein Processing [26]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Gene/Protein Processing [27]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Carbamazepine
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Primidone DM0WX6I Moderate Increased metabolism of Carbamazepine caused by Primidone mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [28]
Felbamate DM1V5ZS Moderate Decreased metabolism of Carbamazepine caused by Felbamate mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [29]
Oxcarbazepine DM5PU6O Moderate Increased metabolism of Carbamazepine caused by Oxcarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [30]
Ethosuximide DMDZ9LT Minor Increased metabolism of Carbamazepine caused by Ethosuximide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [31]
Cenobamate DM8KLU9 Moderate Increased metabolism of Carbamazepine caused by Cenobamate mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [32]
Tiagabine DMKSQG0 Moderate Increased metabolism of Carbamazepine caused by Tiagabine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Stiripentol DMMSDOY Major Increased metabolism of Carbamazepine caused by Stiripentol mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [34]
Fosphenytoin DMOX3LB Moderate Increased metabolism of Carbamazepine caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [35]
Brivaracetam DMSEPK8 Moderate Increased metabolism of Carbamazepine caused by Brivaracetam mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [36]
Clonazepam DMTO13J Moderate Increased metabolism of Carbamazepine caused by Clonazepam mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [36]
Ethotoin DMXWOCP Moderate Increased metabolism of Carbamazepine caused by Ethotoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [35]
Phenobarbital DMXZOCG Minor Increased metabolism of Carbamazepine caused by Phenobarbital mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [37]
Eslicarbazepine DMZREFQ Moderate Increased metabolism of Carbamazepine caused by Eslicarbazepine mediated induction of UGT. Epilepsy/seizure [8A61-8A6Z] [38]
⏷ Show the Full List of 13 DDI Information of This Drug
Coadministration of a Drug Treating the Disease Different from Carbamazepine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Accelerated clearance of Carbamazepine due to the transporter induction by Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [36]
Clindamycin DM15HL8 Moderate Increased metabolism of Carbamazepine caused by Clindamycin mediated induction of CYP450 enzyme. Acne vulgaris [ED80] [39]
Nicotinamide DMUPE07 Minor Decreased metabolism of Carbamazepine caused by Nicotinamide mediated inhibition of CYP450 enzyme. Acquired cutaneous blood vessel malformation [EF20] [40]
Methylene blue DMJAPE7 Major Additive serotonergic effects by the combination of Carbamazepine and Methylene blue. Acquired methaemoglobinaemia [3A93] [41]
Repaglinide DM5SXUV Moderate Increased metabolism of Carbamazepine caused by Repaglinide mediated induction of CYP450 enzyme. Acute diabete complication [5A2Y] [42]
Pioglitazone DMKJ485 Moderate Increased metabolism of Carbamazepine caused by Pioglitazone mediated induction of CYP450 enzyme. Acute diabete complication [5A2Y] [43]
Ivosidenib DM8S6T7 Major Increased metabolism of Carbamazepine caused by Ivosidenib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [44]
Midostaurin DMI6E0R Major Increased metabolism of Carbamazepine caused by Midostaurin mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [45]
Gilteritinib DMTI0ZO Major Increased metabolism of Carbamazepine caused by Gilteritinib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [46]
Emapalumab DMZG5WL Moderate Altered metabolism of Carbamazepine due to Emapalumab alters the formation of CYP450 enzymes. Adaptive immunity immunodeficiency [4A01] [36]
Galantamine DMEO794 Moderate Antagonize the effect of Carbamazepine when combined with Galantamine. Alzheimer disease [8A20] [47]
Donepezil DMIYG7Z Moderate Antagonize the effect of Carbamazepine when combined with Donepezil. Alzheimer disease [8A20] [47]
Siltuximab DMGEATB Moderate Altered metabolism of Carbamazepine due to Siltuximab alters the formation of CYP450 enzymes. Anemia [3A00-3A9Z] [36]
Ivabradine DM0L594 Major Increased metabolism of Carbamazepine caused by Ivabradine mediated induction of CYP450 enzyme. Angina pectoris [BA40] [36]
Bepridil DM0RKS4 Major Increased metabolism of Carbamazepine caused by Bepridil mediated induction of CYP450 enzyme. Angina pectoris [BA40] [48]
Dronedarone DMA8FS5 Moderate Increased metabolism of Carbamazepine caused by Dronedarone mediated induction of CYP450 enzyme. Angina pectoris [BA40] [49]
Nifedipine DMSVOZT Major Increased metabolism of Carbamazepine caused by Nifedipine mediated induction of CYP450 enzyme. Angina pectoris [BA40] [48]
Bedaquiline DM3906J Major Increased metabolism of Carbamazepine caused by Bedaquiline mediated induction of CYP450 enzyme. Antimicrobial drug resistance [MG50-MG52] [36]
Methylphenobarbital DMDSWAG Minor Increased metabolism of Carbamazepine caused by Methylphenobarbital mediated induction of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [50]
Halazepam DMPFWO6 Moderate Increased metabolism of Carbamazepine caused by Halazepam mediated induction of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [51]
Voriconazole DMAOL2S Major Increased metabolism of Carbamazepine caused by Voriconazole mediated induction of CYP450 enzyme. Aspergillosis [1F20] [52]
Posaconazole DMUL5EW Moderate Increased metabolism of Carbamazepine caused by Posaconazole mediated induction of UGT. Aspergillosis [1F20] [36]
Aminophylline DML2NIB Moderate Increased metabolism of Carbamazepine caused by Aminophylline mediated induction of CYP450 enzyme. Asthma [CA23] [53]
Roflumilast DMPGHY8 Moderate Increased metabolism of Carbamazepine caused by Roflumilast mediated induction of CYP450 enzyme. Asthma [CA23] [54]
Desipramine DMT2FDC Moderate Antagonize the effect of Carbamazepine when combined with Desipramine. Attention deficit hyperactivity disorder [6A05] [55]
Dalfopristin DM4LTKV Moderate Decreased metabolism of Carbamazepine caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [56]
Clarithromycin DM4M1SG Major Decreased metabolism of Carbamazepine caused by Clarithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [57]
Linezolid DMGFPU2 Major Additive serotonergic effects by the combination of Carbamazepine and Linezolid. Bacterial infection [1A00-1C4Z] [41]
Telithromycin DMZ4P3A Major Increased metabolism of Carbamazepine caused by Telithromycin mediated induction of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [36]
Retigabine DMGNYIH Moderate Increased metabolism of Carbamazepine caused by Retigabine mediated induction of UGT. Behcet disease [4A62] [58]
Cariprazine DMJYDVK Moderate Increased metabolism of Carbamazepine caused by Cariprazine mediated induction of CYP450 enzyme. Bipolar disorder [6A60] [59]
Erdafitinib DMI782S Major Increased metabolism of Carbamazepine caused by Erdafitinib mediated induction of CYP450 enzyme. Bladder cancer [2C94] [60]
Pexidartinib DMS2J0Z Major Decreased metabolism of Carbamazepine caused by Pexidartinib mediated inhibition of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [61]
Ixabepilone DM2OZ3G Moderate Increased metabolism of Carbamazepine caused by Ixabepilone mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [62]
Lapatinib DM3BH1Y Moderate Increased metabolism of Carbamazepine caused by Lapatinib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [63]
HKI-272 DM6QOVN Major Increased metabolism of Carbamazepine caused by HKI-272 mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [63]
LY2835219 DM93VBZ Major Increased metabolism of Carbamazepine caused by LY2835219 mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [64]
Exemestane DM9HPW3 Moderate Increased metabolism of Carbamazepine caused by Exemestane mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [65]
Esterified estrogens DM9KZDO Moderate Increased metabolism of Carbamazepine caused by Esterified estrogens mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [66]
Tucatinib DMBESUA Major Increased metabolism of Carbamazepine caused by Tucatinib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [67]
Palbociclib DMD7L94 Major Increased metabolism of Carbamazepine caused by Palbociclib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [63]
Alpelisib DMEXMYK Major Increased metabolism of Carbamazepine caused by Alpelisib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [68]
Thiotepa DMIZKOP Moderate Increased metabolism of Carbamazepine caused by Thiotepa mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [69]
Quinestrol DMJ6H1Z Moderate Increased metabolism of Carbamazepine caused by Quinestrol mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [66]
Tamoxifen DMLB0EZ Moderate Increased metabolism of Carbamazepine caused by Tamoxifen mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [70]
Cabazitaxel DMPAZHC Moderate Increased metabolism of Carbamazepine caused by Cabazitaxel mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [71]
Bosutinib DMTI8YE Major Increased metabolism of Carbamazepine caused by Bosutinib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [72]
Estradiol DMUNTE3 Moderate Increased metabolism of Carbamazepine caused by Estradiol mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [66]
Atorvastatin DMF28YC Moderate Increased metabolism of Carbamazepine caused by Atorvastatin mediated induction of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [73]
Macitentan DMP79A1 Major Increased metabolism of Carbamazepine caused by Macitentan mediated induction of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [74]
Doxercalciferol DM6FG1P Moderate Increased metabolism of Carbamazepine caused by Doxercalciferol mediated induction of CYP450 enzyme. Chronic kidney disease [GB61] [75]
Corticotropin DMP9TWZ Moderate Increased metabolism of Carbamazepine caused by Corticotropin mediated induction of CYP450 enzyme. Chronic kidney disease [GB61] [76]
PF-04449913 DMSB068 Major Increased metabolism of Carbamazepine caused by PF-04449913 mediated induction of CYP450 enzyme. Chronic myelomonocytic leukaemia [2A40] [77]
Dihydrocodeine DMB0FWL Moderate Increased metabolism of Carbamazepine caused by Dihydrocodeine mediated induction of CYP450 enzyme. Chronic pain [MG30] [78]
Anisindione DM2C48U Moderate Increased metabolism of Carbamazepine caused by Anisindione mediated induction of CYP450 enzyme. Coagulation defect [3B10] [79]
Regorafenib DMHSY1I Moderate Increased metabolism of Carbamazepine caused by Regorafenib mediated induction of CYP450 enzyme. Colorectal cancer [2B91] [80]
Irinotecan DMP6SC2 Major Increased metabolism of Carbamazepine caused by Irinotecan mediated induction of CYP450 enzyme. Colorectal cancer [2B91] [81]
Intedanib DMSTA36 Major Increased metabolism of Carbamazepine caused by Intedanib mediated induction of CYP450 enzyme. Colorectal cancer [2B91] [82]
Olopatadine DMKMWQG Moderate Additive CNS depression effects by the combination of Carbamazepine and Olopatadine. Conjunctiva disorder [9A60] [83]
Drospirenone DM1A9W3 Major Increased metabolism of Carbamazepine caused by Drospirenone mediated induction of CYP450 enzyme. Contraceptive management [QA21] [66]
Levonorgestrel DM1DP7T Major Increased metabolism of Carbamazepine caused by Levonorgestrel mediated induction of CYP450 enzyme. Contraceptive management [QA21] [66]
Ulipristal DMBNI20 Moderate Increased metabolism of Carbamazepine caused by Ulipristal mediated induction of CYP450 enzyme. Contraceptive management [QA21] [36]
Norgestimate DMYP4XC Major Increased metabolism of Carbamazepine caused by Norgestimate mediated induction of CYP450 enzyme. Contraceptive management [QA21] [84]
Levobupivacaine DM783CH Minor Increased metabolism of Carbamazepine caused by Levobupivacaine mediated induction of CYP450 enzyme. Corneal disease [9A76-9A78] [85]
Oxtriphylline DMLHSE3 Moderate Increased metabolism of Carbamazepine caused by Oxtriphylline mediated induction of CYP450 enzyme. Cough [MD12] [53]
Mifepristone DMGZQEF Moderate Increased metabolism of Carbamazepine caused by Mifepristone mediated induction of CYP450 enzyme. Cushing syndrome [5A70] [86]
Osilodrostat DMIJC9X Major Increased metabolism of Carbamazepine caused by Osilodrostat mediated induction of CYP450 enzyme. Cushing syndrome [5A70] [36]
Ivacaftor DMZC1HS Major Increased metabolism of Carbamazepine caused by Ivacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [63]
Ethanol DMDRQZU Moderate Additive CNS depression effects by the combination of Carbamazepine and Ethanol. Cystitis [GC00] [83]
MK-8228 DMOB58Q Moderate Accelerated clearance of Carbamazepine due to the transporter induction by MK-8228. Cytomegaloviral disease [1D82] [63]
Rivaroxaban DMQMBZ1 Major Increased metabolism of Carbamazepine caused by Rivaroxaban mediated induction of CYP450 enzyme. Deep vein thrombosis [BD71] [52]
Aprepitant DM053KT Moderate Increased metabolism of Carbamazepine caused by Aprepitant mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [87]
Sertraline DM0FB1J Moderate Increased risk of lowers seizure threshold by the combination of Carbamazepine and Sertraline. Depression [6A70-6A7Z] [36]
Vilazodone DM4LECQ Moderate Increased metabolism of Carbamazepine caused by Vilazodone mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [88]
Nefazodone DM4ZS8M Major Decreased metabolism of Carbamazepine caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [89]
Selegiline DM6034S Major Additive serotonergic effects by the combination of Carbamazepine and Selegiline. Depression [6A70-6A7Z] [41]
Vortioxetine DM6F1PU Moderate Increased metabolism of Carbamazepine caused by Vortioxetine mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [90]
Isocarboxazid DMAF1NB Major Additive serotonergic effects by the combination of Carbamazepine and Isocarboxazid. Depression [6A70-6A7Z] [41]
Escitalopram DMFK9HG Minor Increased metabolism of Carbamazepine caused by Escitalopram mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [91]
Tranylcypromine DMGB5RE Major Additive serotonergic effects by the combination of Carbamazepine and Tranylcypromine. Depression [6A70-6A7Z] [41]
OPC-34712 DMHG57U Moderate Increased metabolism of Carbamazepine caused by OPC-34712 mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [92]
Phenelzine DMHIDUE Major Additive serotonergic effects by the combination of Carbamazepine and Phenelzine. Depression [6A70-6A7Z] [41]
Clomipramine DMINRKW Moderate Antagonize the effect of Carbamazepine when combined with Clomipramine. Depression [6A70-6A7Z] [55]
Trazodone DMK1GBJ Moderate Increased metabolism of Carbamazepine caused by Trazodone mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [93]
Doxepin DMPI98T Moderate Increased metabolism of Carbamazepine caused by Doxepin mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [55]
Empagliflozin DMRF9YK Moderate Increased metabolism of Carbamazepine caused by Empagliflozin mediated induction of UGT. Diabetes mellitus [5A10] [63]
Polatuzumab vedotin DMF6Y0L Minor Increased metabolism of Carbamazepine caused by Polatuzumab vedotin mediated induction of CYP450 enzyme. Diffuse large B-cell lymphoma [2A81] [63]
[3H]estrone-3-sulphate DMGPF0N Moderate Increased metabolism of Carbamazepine caused by [3H]estrone-3-sulphate mediated induction of CYP450 enzyme. Discovery agent [N.A.] [94]
Ospemifene DMC4GEI Moderate Increased metabolism of Carbamazepine caused by Ospemifene mediated induction of CYP450 enzyme. Dyspareunia [GA12] [95]
Ingrezza DMVPLNC Major Increased metabolism of Carbamazepine caused by Ingrezza mediated induction of CYP450 enzyme. Dystonic disorder [8A02] [96]
Oestradiol valerate and dienogest DMZK0FQ Major Increased metabolism of Carbamazepine caused by Oestradiol valerate and dienogest mediated induction of CYP450 enzyme. Endometriosis [GA10] [84]
Cannabidiol DM0659E Moderate Increased metabolism of Carbamazepine caused by Cannabidiol mediated induction of CYP450 enzyme. Epileptic encephalopathy [8A62] [36]
Ethacrynic acid DM60QMR Moderate Increased risk of hyponatremia by the combination of Carbamazepine and Ethacrynic acid. Essential hypertension [BA00] [97]
Nicardipine DMCDYW7 Major Increased metabolism of Carbamazepine caused by Nicardipine mediated induction of CYP450 enzyme. Essential hypertension [BA00] [48]
Praziquantel DMOU1PK Major Increased metabolism of Carbamazepine caused by Praziquantel mediated induction of CYP450 enzyme. Flatworm infection [1F70-1F86] [98]
Bay 80-6946 DMLOS5R Major Accelerated clearance of Carbamazepine due to the transporter induction by Bay 80-6946. Follicular lymphoma [2A80] [99]
Tazemetostat DMWP1BH Major Increased metabolism of Carbamazepine caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [100]
Mirabegron DMS1GYT Minor Increased metabolism of Carbamazepine caused by Mirabegron mediated induction of CYP450 enzyme. Functional bladder disorder [GC50] [101]
Itraconazole DMCR1MV Moderate Increased metabolism of Carbamazepine caused by Itraconazole mediated induction of CYP450 enzyme. Fungal infection [1F29-1F2F] [102]
Miconazole DMPMYE8 Moderate Decreased metabolism of Carbamazepine caused by Miconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [36]
Ripretinib DM958QB Major Increased metabolism of Carbamazepine caused by Ripretinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [103]
Sunitinib DMCBJSR Major Increased metabolism of Carbamazepine caused by Sunitinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [63]
Avapritinib DMK2GZX Major Increased metabolism of Carbamazepine caused by Avapritinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [36]
Sulfinpyrazone DMEV954 Moderate Increased metabolism of Carbamazepine caused by Sulfinpyrazone mediated induction of CYP450 enzyme. Gout [FA25] [37]
Ergotamine DMKR3C5 Moderate Increased metabolism of Carbamazepine caused by Ergotamine mediated induction of CYP450 enzyme. Headache [8A80-8A84] [63]
Eplerenone DMF0NQR Minor Increased metabolism of Carbamazepine caused by Eplerenone mediated induction of CYP450 enzyme. Heart failure [BD10-BD1Z] [104]
Chlorothiazide DMLHESP Moderate Increased risk of hyponatremia by the combination of Carbamazepine and Chlorothiazide. Heart failure [BD10-BD1Z] [105]
Furosemide DMMQ8ZG Moderate Increased risk of hyponatremia by the combination of Carbamazepine and Furosemide. Heart failure [BD10-BD1Z] [105]
Amiloride DMRTSGP Moderate Increased risk of hyponatremia by the combination of Carbamazepine and Amiloride. Heart failure [BD10-BD1Z] [105]
Bumetanide DMRV7H0 Moderate Increased risk of hyponatremia by the combination of Carbamazepine and Bumetanide. Heart failure [BD10-BD1Z] [105]
Hydroflumethiazide DMVPUQI Moderate Increased risk of hyponatremia by the combination of Carbamazepine and Hydroflumethiazide. Heart failure [BD10-BD1Z] [105]
Boceprevir DMBSHMF Major Increased metabolism of Carbamazepine caused by Boceprevir mediated induction of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [106]
PSI-7977 DMLSUWZ Major Accelerated clearance of Carbamazepine due to the transporter induction by PSI-7977. Hepatitis virus infection [1E50-1E51] [36]
Simeprevir DMLUA9D Major Increased metabolism of Carbamazepine caused by Simeprevir mediated induction of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [107]
Telaprevir DMMRV29 Major Increased metabolism of Carbamazepine caused by Telaprevir mediated induction of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [108]
ABT-267 DMNQ869 Major Increased metabolism of Carbamazepine caused by ABT-267 mediated induction of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [36]
Daclatasvir DMSFK9V Major Increased metabolism of Carbamazepine caused by Daclatasvir mediated induction of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [36]
Isoniazid DM5JVS3 Moderate Decreased metabolism of Carbamazepine caused by Isoniazid mediated inhibition of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [109]
Rifampin DMA8J1G Moderate Increased metabolism of Carbamazepine caused by Rifampin mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [110]
Pretomanid DMDYA31 Major Increased metabolism of Carbamazepine caused by Pretomanid mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [111]
Procarbazine DMIK367 Major Additive serotonergic effects by the combination of Carbamazepine and Procarbazine. Hodgkin lymphoma [2B30] [41]
Brentuximab vedotin DMWLC57 Moderate Increased risk of hepatotoxicity by the combination of Carbamazepine and Brentuximab vedotin. Hodgkin lymphoma [2B30] [112]
MK-1439 DM215WE Major Increased metabolism of Carbamazepine caused by MK-1439 mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [113]
Delavirdine DM3NF5G Major Increased metabolism of Carbamazepine caused by Delavirdine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [114]
Fosamprenavir DM4W9B3 Moderate Increased metabolism of Carbamazepine caused by Fosamprenavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [115]
Cobicistat DM6L4H2 Major Increased metabolism of Carbamazepine caused by Cobicistat mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [63]
Tipranavir DM8HJX6 Moderate Increased metabolism of Carbamazepine caused by Tipranavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [115]
Efavirenz DMC0GSJ Moderate Increased metabolism of Carbamazepine caused by Efavirenz mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [116]
Dolutegravir DMCZGRE Major Increased metabolism of Carbamazepine caused by Dolutegravir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [63]
Saquinavir DMG814N Moderate Increased metabolism of Carbamazepine caused by Saquinavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [115]
Elvitegravir DMG9B1U Major Increased metabolism of Carbamazepine caused by Elvitegravir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [63]
Etravirine DMGV8QU Major Increased metabolism of Carbamazepine caused by Etravirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [117]
Lopinavir DMITQS0 Major Increased metabolism of Carbamazepine caused by Lopinavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [118]
Rilpivirine DMJ0QOW Major Increased metabolism of Carbamazepine caused by Rilpivirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [119]
Amprenavir DMLMXE0 Moderate Increased metabolism of Carbamazepine caused by Amprenavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [115]
Darunavir DMN3GCH Major Increased metabolism of Carbamazepine caused by Darunavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [52]
Atazanavir DMSYRBX Moderate Increased metabolism of Carbamazepine caused by Atazanavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [115]
Maraviroc DMTL94F Major Increased metabolism of Carbamazepine caused by Maraviroc mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [120]
Raltegravir DMYURI6 Minor Increased metabolism of Carbamazepine caused by Raltegravir mediated induction of UGT. Human immunodeficiency virus disease [1C60-1C62] [52]
Simvastatin DM30SGU Moderate Increased metabolism of Carbamazepine caused by Simvastatin mediated induction of CYP450 enzyme. Hyper-lipoproteinaemia [5C80] [121]
Mipomersen DMGSRN1 Major Increased risk of hepatotoxicity by the combination of Carbamazepine and Mipomersen. Hyper-lipoproteinaemia [5C80] [122]
Teriflunomide DMQ2FKJ Major Increased risk of hepatotoxicity by the combination of Carbamazepine and Teriflunomide. Hyper-lipoproteinaemia [5C80] [52]
Paricalcitol DMYBV3G Moderate Increased metabolism of Carbamazepine caused by Paricalcitol mediated induction of CYP450 enzyme. Hyper-parathyroidism [5A51] [75]
Levamlodipine DM92S6N Major Increased metabolism of Carbamazepine caused by Levamlodipine mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [48]
Indapamide DMGN1PW Moderate Increased risk of hyponatremia by the combination of Carbamazepine and Indapamide. Hypertension [BA00-BA04] [105]
Trichlormethiazide DMHAQCO Moderate Increased risk of hyponatremia by the combination of Carbamazepine and Trichlormethiazide. Hypertension [BA00-BA04] [105]
Felodipine DMOSW35 Moderate Increased metabolism of Carbamazepine caused by Felodipine mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [48]
Hydrochlorothiazide DMUSZHD Moderate Increased risk of hyponatremia by the combination of Carbamazepine and Hydrochlorothiazide. Hypertension [BA00-BA04] [105]
Conivaptan DM1V329 Moderate Decreased metabolism of Carbamazepine caused by Conivaptan mediated inhibition of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [123]
Tolvaptan DMIWFRL Major Increased metabolism of Carbamazepine caused by Tolvaptan mediated induction of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [36]
Fludrocortisone DMUDIR8 Moderate Increased metabolism of Carbamazepine caused by Fludrocortisone mediated induction of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [76]
Pirfenidone DM6VZFQ Moderate Increased metabolism of Carbamazepine caused by Pirfenidone mediated induction of CYP450 enzyme. Idiopathic interstitial pneumonitis [CB03] [36]
Vitamin B3 DMQVRZH Minor Decreased metabolism of Carbamazepine caused by Vitamin B3 mediated inhibition of CYP450 enzyme. Inborn lipid metabolism error [5C52] [40]
Febuxostat DMDEXQ0 Minor Increased metabolism of Carbamazepine caused by Febuxostat mediated induction of UGT. Inborn purine/pyrimidine/nucleotide metabolism error [5C55] [36]
Probenecid DMMFWOJ Minor Increased metabolism of Carbamazepine caused by Probenecid mediated induction of CYP450 enzyme. Inborn purine/pyrimidine/nucleotide metabolism error [5C55] [124]
Lesinurad DMUR64T Moderate Increased metabolism of Carbamazepine caused by Lesinurad mediated induction of CYP450 enzyme. Inborn purine/pyrimidine/nucleotide metabolism error [5C55] [125]
TP-434 DM5A31S Major Increased metabolism of Carbamazepine caused by TP-434 mediated induction of CYP450 enzyme. Infectious gastroenteritis/colitis [1A40] [126]
Suvorexant DM0E6S3 Major Increased metabolism of Carbamazepine caused by Suvorexant mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [127]
Amobarbital DM0GQ8N Minor Increased metabolism of Carbamazepine caused by Amobarbital mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [37]
Ramelteon DM7IW9J Moderate Increased metabolism of Carbamazepine caused by Ramelteon mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [128]
Flurazepam DMAL4G0 Moderate Increased metabolism of Carbamazepine caused by Flurazepam mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [51]
Triazolam DMETYK5 Moderate Increased metabolism of Carbamazepine caused by Triazolam mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [51]
Zaleplon DMGFWSM Moderate Increased metabolism of Carbamazepine caused by Zaleplon mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [129]
Melatonin DMKWFBT Minor Increased metabolism of Carbamazepine caused by Melatonin mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [63]
Tasimelteon DMLOQ1V Major Increased metabolism of Carbamazepine caused by Tasimelteon mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [130]
ITI-007 DMUQ1DO Major Increased metabolism of Carbamazepine caused by ITI-007 mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [131]
Quazepam DMY4D87 Moderate Increased metabolism of Carbamazepine caused by Quazepam mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [51]
Estazolam DMZGXUM Moderate Increased metabolism of Carbamazepine caused by Estazolam mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [51]
Naloxegol DML0B41 Major Increased metabolism of Carbamazepine caused by Naloxegol mediated induction of CYP450 enzyme. Large intestine motility disorder [DB32] [36]
Pemigatinib DM819JF Major Increased metabolism of Carbamazepine caused by Pemigatinib mediated induction of CYP450 enzyme. Liver cancer [2C12] [36]
Crizotinib DM4F29C Major Increased metabolism of Carbamazepine caused by Crizotinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [63]
Porfimer Sodium DM7ZWNY Moderate Increased risk of photosensitivity reactions by the combination of Carbamazepine and Porfimer Sodium. Lung cancer [2C25] [132]
Ceritinib DMB920Z Major Increased metabolism of Carbamazepine caused by Ceritinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [133]
Lurbinectedin DMEFRTZ Major Decreased metabolism of Carbamazepine caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [134]
PF-06463922 DMKM7EW Major Increased metabolism of Carbamazepine caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [135]
Osimertinib DMRJLAT Major Increased metabolism of Carbamazepine caused by Osimertinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [63]
BIBW 2992 DMTKD7Q Moderate Accelerated clearance of Carbamazepine due to the transporter induction by BIBW 2992. Lung cancer [2C25] [136]
Pralsetinib DMWU0I2 Major Increased metabolism of Carbamazepine caused by Pralsetinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [137]
Capmatinib DMYCXKL Major Increased metabolism of Carbamazepine caused by Capmatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [138]
Selpercatinib DMZR15V Major Increased metabolism of Carbamazepine caused by Selpercatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [36]
Artesunate DMR27C8 Moderate Increased metabolism of Carbamazepine caused by Artesunate mediated induction of UGT. Malaria [1F40-1F45] [139]
Chloroquine DMSI5CB Moderate Increased metabolism of Carbamazepine caused by Chloroquine mediated induction of CYP450 enzyme. Malaria [1F40-1F45] [63]
Hydroxychloroquine DMSIVND Moderate Increased metabolism of Carbamazepine caused by Hydroxychloroquine mediated induction of CYP450 enzyme. Malaria [1F40-1F45] [63]
Calaspargase pegol DMQZBXI Moderate Increased risk of hepatotoxicity by the combination of Carbamazepine and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [140]
Idelalisib DM602WT Major Increased metabolism of Carbamazepine caused by Idelalisib mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [141]
GDC-0199 DMH0QKA Major Increased metabolism of Carbamazepine caused by GDC-0199 mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [142]
IPI-145 DMWA24P Major Increased metabolism of Carbamazepine caused by IPI-145 mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [143]
Acalabrutinib DM7GCVW Major Increased metabolism of Carbamazepine caused by Acalabrutinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [144]
Clofarabine DMCVJ86 Moderate Increased risk of hepatotoxicity by the combination of Carbamazepine and Clofarabine. Mature B-cell lymphoma [2A85] [145]
Blinatumomab DMGECIJ Moderate Decreased metabolism of Carbamazepine caused by Blinatumomab mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [146]
Ibrutinib DMHZCPO Major Increased metabolism of Carbamazepine caused by Ibrutinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [36]
Ponatinib DMYGJQO Moderate Increased metabolism of Carbamazepine caused by Ponatinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [63]
Arry-162 DM1P6FR Moderate Increased metabolism of Carbamazepine caused by Arry-162 mediated induction of UGT. Melanoma [2C30] [63]
Vemurafenib DM62UG5 Major Increased metabolism of Carbamazepine caused by Vemurafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [63]
Selumetinib DMC7W6R Major Increased metabolism of Carbamazepine caused by Selumetinib mediated induction of CYP450 enzyme. Melanoma [2C30] [147]
LGX818 DMNQXV8 Major Increased metabolism of Carbamazepine caused by LGX818 mediated induction of CYP450 enzyme. Melanoma [2C30] [148]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Carbamazepine caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [63]
Estrone DM5T6US Moderate Increased metabolism of Carbamazepine caused by Estrone mediated induction of CYP450 enzyme. Menopausal disorder [GA30] [66]
Ethinyl estradiol DMODJ40 Major Increased metabolism of Carbamazepine caused by Ethinyl estradiol mediated induction of CYP450 enzyme. Menopausal disorder [GA30] [84]
Danazol DML8KTN Moderate Decreased metabolism of Carbamazepine caused by Danazol mediated inhibition of CYP450 enzyme. Menstrual cycle bleeding disorder [GA20] [149]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Carbamazepine and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [150]
Ubrogepant DM749I3 Major Increased metabolism of Carbamazepine caused by Ubrogepant mediated induction of CYP450 enzyme. Migraine [8A80] [151]
Rimegepant DMHOAUG Major Increased metabolism of Carbamazepine caused by Rimegepant mediated induction of CYP450 enzyme. Migraine [8A80] [152]
Lasmiditan DMXLVDT Moderate Additive CNS depression effects by the combination of Carbamazepine and Lasmiditan. Migraine [8A80] [153]
Exjade DMHPRWG Moderate Increased metabolism of Carbamazepine caused by Exjade mediated induction of UGT. Mineral absorption/transport disorder [5C64] [63]
Dihydrotachysterol DMFB97P Moderate Increased metabolism of Carbamazepine caused by Dihydrotachysterol mediated induction of CYP450 enzyme. Mineral deficiency [5B5K] [75]
Flibanserin DM70DTN Major Increased metabolism of Carbamazepine caused by Flibanserin mediated induction of CYP450 enzyme. Mood disorder [6A60-6E23] [154]
Midazolam DMXOELT Moderate Increased metabolism of Carbamazepine caused by Midazolam mediated induction of CYP450 enzyme. Mood/affect symptom [MB24] [51]
Panobinostat DM58WKG Major Increased metabolism of Carbamazepine caused by Panobinostat mediated induction of CYP450 enzyme. Multiple myeloma [2A83] [155]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Carbamazepine and Thalidomide. Multiple myeloma [2A83] [156]
Siponimod DM2R86O Major Increased metabolism of Carbamazepine caused by Siponimod mediated induction of CYP450 enzyme. Multiple sclerosis [8A40] [63]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Carbamazepine and Ocrelizumab. Multiple sclerosis [8A40] [157]
Ozanimod DMT6AM2 Major Additive serotonergic effects by the combination of Carbamazepine and Ozanimod. Multiple sclerosis [8A40] [158]
Deflazacort DMV0RNS Major Increased metabolism of Carbamazepine caused by Deflazacort mediated induction of CYP450 enzyme. Muscular dystrophy [8C70] [36]
Rifabutin DM1YBHK Moderate Increased metabolism of Carbamazepine caused by Rifabutin mediated induction of CYP450 enzyme. Mycobacterium infection [1B10-1B21] [37]
Romidepsin DMT5GNL Moderate Increased metabolism of Carbamazepine caused by Romidepsin mediated induction of CYP450 enzyme. Mycosis fungoides [2B01] [159]
Fedratinib DM4ZBK6 Major Increased metabolism of Carbamazepine caused by Fedratinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [36]
Nilotinib DM7HXWT Major Increased metabolism of Carbamazepine caused by Nilotinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [160]
Imatinib DM7RJXL Major Increased metabolism of Carbamazepine caused by Imatinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [161]
Dasatinib DMJV2EK Major Increased metabolism of Carbamazepine caused by Dasatinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [63]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive immunosuppressive effects by the combination of Carbamazepine and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [162]
Vorapaxar DMA16BR Major Increased metabolism of Carbamazepine caused by Vorapaxar mediated induction of CYP450 enzyme. Myocardial infarction [BA41-BA43] [163]
Modafinil DMYILBE Moderate Increased metabolism of Carbamazepine caused by Modafinil mediated induction of CYP450 enzyme. Narcolepsy [7A20] [63]
Rolapitant DM8XP26 Major Increased metabolism of Carbamazepine caused by Rolapitant mediated induction of CYP450 enzyme. Nausea/vomiting [MD90] [36]
Netupitant DMEKAYI Major Increased metabolism of Carbamazepine caused by Netupitant mediated induction of CYP450 enzyme. Nausea/vomiting [MD90] [63]
Ondansetron DMOTQ1I Moderate Increased metabolism of Carbamazepine caused by Ondansetron mediated induction of CYP450 enzyme. Nausea/vomiting [MD90] [36]
E-2007 DMJDYNQ Moderate Increased metabolism of Carbamazepine caused by E-2007 mediated induction of CYP450 enzyme. Neuropathy [8C0Z] [36]
Bupropion DM5PCS7 Moderate Increased metabolism of Carbamazepine caused by Bupropion mediated induction of CYP450 enzyme. Nicotine use disorder [6C4A] [63]
Entrectinib DMMPTLH Major Increased metabolism of Carbamazepine caused by Entrectinib mediated induction of CYP450 enzyme. Non-small cell lung cancer [2C25] [164]
Polythiazide DMCH80F Moderate Increased risk of hyponatremia by the combination of Carbamazepine and Polythiazide. Oedema [MG29] [105]
Levomethadyl Acetate DM06HG5 Major Increased metabolism of Carbamazepine caused by Levomethadyl Acetate mediated induction of CYP450 enzyme. Opioid use disorder [6C43] [165]
S-297995 DM26IH8 Major Increased metabolism of Carbamazepine caused by S-297995 mediated induction of CYP450 enzyme. Opioid use disorder [6C43] [166]
Apraclonidine DMO4PVE Moderate Additive CNS depression effects by the combination of Carbamazepine and Apraclonidine. Optic nerve disorder [9C40] [167]
Valdecoxib DMAY7H4 Moderate Increased metabolism of Carbamazepine caused by Valdecoxib mediated induction of CYP450 enzyme. Osteoarthritis [FA00-FA05] [168]
Diclofenac DMPIHLS Moderate Increased metabolism of Carbamazepine caused by Diclofenac mediated induction of CYP450 enzyme. Osteoarthritis [FA00-FA05] [63]
Olaparib DM8QB1D Major Increased metabolism of Carbamazepine caused by Olaparib mediated induction of CYP450 enzyme. Ovarian cancer [2C73] [63]
Rucaparib DM9PVX8 Moderate Increased metabolism of Carbamazepine caused by Rucaparib mediated induction of CYP450 enzyme. Ovarian cancer [2C73] [169]
MK-4827 DMLYGH4 Moderate Accelerated clearance of Carbamazepine due to the transporter induction by MK-4827. Ovarian cancer [2C73] [170]
Dextropropoxyphene DM23HCX Major Decreased metabolism of Carbamazepine caused by Dextropropoxyphene mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [171]
Butorphanol DM5KYPJ Major Increased metabolism of Carbamazepine caused by Butorphanol mediated induction of CYP450 enzyme. Pain [MG30-MG3Z] [63]
Hydrocodone DMQ2JO5 Major Increased metabolism of Carbamazepine caused by Hydrocodone mediated induction of CYP450 enzyme. Pain [MG30-MG3Z] [63]
Istradefylline DM20VSK Major Increased metabolism of Carbamazepine caused by Istradefylline mediated induction of CYP450 enzyme. Parkinsonism [8A00] [172]
Rasagiline DM3WKQ4 Major Additive serotonergic effects by the combination of Carbamazepine and Rasagiline. Parkinsonism [8A00] [41]
Pimavanserin DMR7IVC Moderate Increased metabolism of Carbamazepine caused by Pimavanserin mediated induction of CYP450 enzyme. Parkinsonism [8A00] [173]
Abametapir DM2RX0I Moderate Decreased metabolism of Carbamazepine caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [174]
Lefamulin DME6G97 Major Accelerated clearance of Carbamazepine due to the transporter induction by Lefamulin. Pneumonia [CA40] [175]
Prednisone DM2HG4X Moderate Increased metabolism of Carbamazepine caused by Prednisone mediated induction of CYP450 enzyme. Postoperative inflammation [1A00-CA43] [76]
Hydrocortisone DMGEMB7 Moderate Increased metabolism of Carbamazepine caused by Hydrocortisone mediated induction of CYP450 enzyme. Postoperative inflammation [1A00-CA43] [76]
Ergonovine DM0VEC1 Moderate Increased metabolism of Carbamazepine caused by Ergonovine mediated induction of CYP450 enzyme. Postpartum haemorrhage [JA43] [63]
Lonafarnib DMGM2Z6 Major Increased metabolism of Carbamazepine caused by Lonafarnib mediated induction of CYP450 enzyme. Premature ageing appearance [LD2B] [176]
ABIRATERONE DM8V75C Major Increased metabolism of Carbamazepine caused by ABIRATERONE mediated induction of CYP450 enzyme. Prostate cancer [2C82] [177]
Relugolix DMK7IWL Major Increased metabolism of Carbamazepine caused by Relugolix mediated induction of CYP450 enzyme. Prostate cancer [2C82] [178]
Darolutamide DMV7YFT Major Increased metabolism of Carbamazepine caused by Darolutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [179]
Ustekinumab DMHTYK3 Moderate Altered metabolism of Carbamazepine due to Ustekinumab alters the formation of CYP450 enzymes. Psoriasis [EA90] [36]
Apremilast DMTWS9E Major Increased metabolism of Carbamazepine caused by Apremilast mediated induction of CYP450 enzyme. Psoriasis [EA90] [180]
Ixekizumab DMXW92T Moderate Altered metabolism of Carbamazepine due to Ixekizumab alters the formation of CYP450 enzymes. Psoriasis [EA90] [36]
Riociguat DMXBLMP Moderate Increased metabolism of Carbamazepine caused by Riociguat mediated induction of CYP450 enzyme. Pulmonary hypertension [BB01] [181]
Everolimus DM8X2EH Major Increased metabolism of Carbamazepine caused by Everolimus mediated induction of CYP450 enzyme. Renal cell carcinoma [2C90] [52]
Axitinib DMGVH6N Major Increased metabolism of Carbamazepine caused by Axitinib mediated induction of CYP450 enzyme. Renal cell carcinoma [2C90] [182]
Temsirolimus DMS104F Major Increased metabolism of Carbamazepine caused by Temsirolimus mediated induction of CYP450 enzyme. Renal cell carcinoma [2C90] [63]
Upadacitinib DM32B5U Major Increased metabolism of Carbamazepine caused by Upadacitinib mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [183]
Tocilizumab DM7J6OR Moderate Altered metabolism of Carbamazepine due to Tocilizumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [36]
Canakinumab DM8HLO5 Moderate Altered metabolism of Carbamazepine due to Canakinumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [36]
Tofacitinib DMBS370 Major Increased metabolism of Carbamazepine caused by Tofacitinib mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [63]
Rilonacept DMGLUQS Moderate Altered metabolism of Carbamazepine due to Rilonacept alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [36]
Golimumab DMHZV7X Moderate Altered metabolism of Carbamazepine due to Golimumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [36]
Dexamethasone DMMWZET Moderate Increased metabolism of Carbamazepine caused by Dexamethasone mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [76]
Sarilumab DMOGNXY Moderate Altered metabolism of Carbamazepine due to Sarilumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [36]
Leflunomide DMR8ONJ Major Increased risk of hepatotoxicity by the combination of Carbamazepine and Leflunomide. Rheumatoid arthritis [FA20] [52]
Quetiapine DM1N62C Major Increased metabolism of Carbamazepine caused by Quetiapine mediated induction of CYP450 enzyme. Schizophrenia [6A20] [63]
Aripiprazole DM3NUMH Moderate Increased metabolism of Carbamazepine caused by Aripiprazole mediated induction of CYP450 enzyme. Schizophrenia [6A20] [184]
Paliperidone DM7NPJS Moderate Accelerated clearance of Carbamazepine due to the transporter induction by Paliperidone. Schizophrenia [6A20] [63]
Thiothixene DMDINC4 Moderate Increased metabolism of Carbamazepine caused by Thiothixene mediated induction of CYP450 enzyme. Schizophrenia [6A20] [185]
Fentanyl DM8WAHT Major Increased metabolism of Carbamazepine caused by Fentanyl mediated induction of CYP450 enzyme. Sensation disturbance [MB40] [63]
Avanafil DM75CXN Moderate Increased metabolism of Carbamazepine caused by Avanafil mediated induction of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [186]
Tadalafil DMJZHT1 Moderate Increased metabolism of Carbamazepine caused by Tadalafil mediated induction of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [36]
Voxelotor DMCS6M5 Major Increased metabolism of Carbamazepine caused by Voxelotor mediated induction of CYP450 enzyme. Sickle-cell disorder [3A51] [187]
LDE225 DMM9F25 Major Increased metabolism of Carbamazepine caused by LDE225 mediated induction of CYP450 enzyme. Skin cancer [2C30-2C37] [188]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Carbamazepine caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [36]
Larotrectinib DM26CQR Major Accelerated clearance of Carbamazepine due to the transporter induction by Larotrectinib. Solid tumour/cancer [2A00-2F9Z] [63]
Methylprednisolone DM4BDON Moderate Increased metabolism of Carbamazepine caused by Methylprednisolone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [76]
Vinblastine DM5TVS3 Moderate Increased metabolism of Carbamazepine caused by Vinblastine mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [189]
Docetaxel DMDI269 Moderate Increased metabolism of Carbamazepine caused by Docetaxel mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [190]
Trabectedin DMG3Y89 Major Increased metabolism of Carbamazepine caused by Trabectedin mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [36]
Armodafinil DMGB035 Moderate Increased metabolism of Carbamazepine caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [63]
LEE011 DMMX75K Major Decreased metabolism of Carbamazepine caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [191]
Etoposide DMNH3PG Moderate Increased metabolism of Carbamazepine caused by Etoposide mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [192]
Prednisolone DMQ8FR2 Moderate Increased metabolism of Carbamazepine caused by Prednisolone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [76]
Vandetanib DMRICNP Moderate Increased metabolism of Carbamazepine caused by Vandetanib mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [193]
Norethindrone DMTY169 Major Increased metabolism of Carbamazepine caused by Norethindrone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [84]
Taxol DMUOT9V Moderate Increased metabolism of Carbamazepine caused by Taxol mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [194]
Pitolisant DM8RFNJ Major Increased metabolism of Carbamazepine caused by Pitolisant mediated induction of CYP450 enzyme. Somnolence [MG42] [36]
Naltrexone DMUL45H Moderate Increased risk of hepatotoxicity by the combination of Carbamazepine and Naltrexone. Substance abuse [6C40] [195]
Warfarin DMJYCVW Moderate Increased metabolism of Carbamazepine caused by Warfarin mediated induction of CYP450 enzyme. Supraventricular tachyarrhythmia [BC81] [79]
Pomalidomide DMTGBAX Moderate Accelerated clearance of Carbamazepine due to the transporter induction by Pomalidomide. Systemic sclerosis [4A42] [196]
Fostamatinib DM6AUHV Major Increased metabolism of Carbamazepine caused by Fostamatinib mediated induction of CYP450 enzyme. Thrombocytopenia [3B64] [197]
As-1670542 DMV05SW Major Increased metabolism of Carbamazepine caused by As-1670542 mediated induction of CYP450 enzyme. Thrombocytopenia [3B64] [198]
Apixaban DM89JLN Major Accelerated clearance of Carbamazepine due to the transporter induction by Apixaban. Thrombosis [DB61-GB90] [36]
Brilinta DMBR01X Major Increased metabolism of Carbamazepine caused by Brilinta mediated induction of CYP450 enzyme. Thrombosis [DB61-GB90] [199]
Cabozantinib DMIYDT4 Major Increased metabolism of Carbamazepine caused by Cabozantinib mediated induction of CYP450 enzyme. Thyroid cancer [2D10] [200]
Tizanidine DMR2IQ4 Moderate Additive CNS depression effects by the combination of Carbamazepine and Tizanidine. Tonus and reflex abnormality [MB47] [201]
Sirolimus DMGW1ID Major Accelerated clearance of Carbamazepine due to the transporter induction by Sirolimus. Transplant rejection [NE84] [63]
Tacrolimus DMZ7XNQ Major Increased metabolism of Carbamazepine caused by Tacrolimus mediated induction of CYP450 enzyme. Transplant rejection [NE84] [202]
Canagliflozin DMFRM1I Moderate Increased metabolism of Carbamazepine caused by Canagliflozin mediated induction of UGT. Type 2 diabetes mellitus [5A11] [63]
Linagliptin DMWFJTR Moderate Increased metabolism of Carbamazepine caused by Linagliptin mediated induction of CYP450 enzyme. Type 2 diabetes mellitus [5A11] [203]
Elagolix DMB2C0E Moderate Increased metabolism of Carbamazepine caused by Elagolix mediated induction of CYP450 enzyme. Uterine fibroid [2E86] [204]
Triamcinolone DM98IXF Moderate Increased metabolism of Carbamazepine caused by Triamcinolone mediated induction of CYP450 enzyme. Vasomotor/allergic rhinitis [CA08] [76]
Betrixaban DM2C4RF Moderate Accelerated clearance of Carbamazepine due to the transporter induction by Betrixaban. Venous thromboembolism [BD72] [205]
Amiodarone DMUTEX3 Major Increased metabolism of Carbamazepine caused by Amiodarone mediated induction of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [206]
Ganciclovir DM1MBYQ Moderate Additive myelosuppressive effects by the combination of Carbamazepine and Ganciclovir. Virus infection [1A24-1D9Z] [63]
Valganciclovir DMS2IUH Moderate Additive myelosuppressive effects by the combination of Carbamazepine and Valganciclovir. Virus infection [1A24-1D9Z] [63]
⏷ Show the Full List of 311 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Allura red AC dye E00338 33258 Colorant
D&C red no. 28 E00491 6097185 Colorant
D&C red no. 30 E00456 3000709 Colorant
Diethyl phthalate E00135 6781 Plasticizing agent; Solvent
FD&C blue no. 1 E00263 19700 Colorant
FD&C blue no. 2 E00446 2723854 Colorant
Mannitol E00103 6251 Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Oleic acid E00421 445639 Emulsifying agent; Penetration agent; Solubilizing agent
Quinoline yellow WS E00309 24671 Colorant
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Stearic acid E00079 5281 Emulsifying agent; Solubilizing agent; Viscosity-controlling agent; lubricant
Sunset yellow FCF E00255 17730 Colorant
Carmellose sodium E00625 Not Available Disintegrant
Citric acid monohydrate E00271 22230 Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
Eisenoxyd E00585 56841934 Colorant
FD&C red no. 3 E00629 Not Available Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Ferrosoferric oxide E00231 14789 Colorant
Glycerin E00026 753 Antimicrobial preservative; Emollient; Flavoring agent; Humectant; Lubricant; Plasticizing agent; Solvent; Suppository base; Tonicity agent; Viscosity-controlling agent
Hexahydric alcohol E00083 5780 Diluent; Flavoring agent; Humectant; Plasticizing agent
Hypromellose E00634 Not Available Coating agent
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Medium-chain triglyceride E00640 Not Available Emollient; Lubricant; Surfactant
Poloxamer 188 E00645 Not Available Emulsifying agent; Solubilizing agent; Surfactant
Potassium sorbate E00566 23676745 Antimicrobial preservative
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Propylene glycol distearate E00395 110800 Emollient; Opacifying agent; Surfactant
Saccharose E00091 5988 Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium hydroxide E00234 14798 Alkalizing agent
Sorbitan monolaurate E00508 11046239 Dispersing agent; Emulsifying agent; Solubilizing agent; Surfactant; Suspending agent; Vaccine adjuvant
Sucrose 1,6-distearate E00593 71587490 Dispersing agent; Emulsifying agent; Modified-release agent; Solubilizing agent; Surfactant; lubricant
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Triethyl citrate E00128 6506 Plasticizing agent; Solvent
⏷ Show the Full List of 37 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Carbamazepine 100 mg capsule 100 mg 12 HR Extended Release Oral Capsule Oral
Carbamazepine 200 mg capsule 200 mg 12 HR Extended Release Oral Capsule Oral
Carbamazepine 200 mg tablet 200 mg Chewable Tablet Oral
Carbamazepine 300 mg capsule 300 mg 12 HR Extended Release Oral Capsule Oral
Carbamazepine 100 mg tablet 100 mg Chewable Tablet Oral
Carbamazepine 200 mg tablet 200 mg 12 HR Extended Release Oral Tablet Oral
Carbamazepine 200 mg tablet 200 mg 12 HR Extended Release Tablet Oral
Carbamazepine 100 mg tablet 100 mg 12 HR Extended Release Oral Tablet Oral
Carbamazepine 400 mg tablet 400 mg 12 HR Extended Release Oral Tablet Oral
Carbamazepine 400 mg tablet 400 mg 12 HR Extended Release Tablet Oral
Carbamazepine 100 mg tablet 100 mg Oral Tablet Oral
Carbamazepine 200 mg tablet 200 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

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175 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
176 Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
177 Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.
178 Product Information. Orgovyx (relugolix). Myovant Sciences, Inc., Brisbane, CA.
179 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
180 Product Information. Otezla (apremilast). Celgene Corporation, Summit, NJ.
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187 Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
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195 Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
196 Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
197 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
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200 Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
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203 Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
204 Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
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