Details of Disease

General Information of Disease (ID: DISI7I8Y)

Disease Name	Subarachnoid hemorrhage
Synonyms	subarachnoid hemorrhage; subarachnoid hemorrhage (disease); subarachnoid haemorrhage (disease)
Disease Class	8B01: Subarachnoid haemorrhage
Definition	Intracranial hemorrhage into the subarachnoid space.
Disease Hierarchy	DIS1GZDX: Neurovascular disorder DIS6ZC3X: Brain disease DISI7I8Y: Subarachnoid hemorrhage
ICD Code	ICD-11 ICD-11: 8B01 Expand ICD-11 '8B01 Expand ICD-10 'I60; 'I60.8; 'I60.9 Expand ICD-9 430,852.0,852.1
Disease Identifiers	MONDO ID MONDO_0005099 MESH ID D013345 UMLS CUI C0038525 MedGen ID 11625 HPO ID HP:0002138 SNOMED CT ID 21454007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Tirilazad mesylate	DMCRIHP	Approved	Small molecular drug	[1]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
EG-1962	DMTM62W	Phase 3	NA	[2]
SFX-01	DMAQW9M	Phase 2	NA	[3]
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This Disease is Treated as An Indication in 1 Drugs in Phase 1 Trial

Drug Name	Drug ID	Highest Status	Drug Type	REF
Deferoxamine	DMG0C81	Phase 1/2 Trial	Small molecular drug	[4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 84 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADORA1	TTK25J1	Limited	Biomarker	[5]
ADRB1	TTR6W5O	Limited	Biomarker	[6]
CRY2	TTAO58M	Limited	Biomarker	[7]
CTSG	TTQAJF1	Limited	Altered Expression	[8]
EDN1	TTJR60Z	Limited	Biomarker	[9]
EDNRB	TT3ZTGU	Limited	Altered Expression	[10]
EPHA4	TTG84D3	Limited	Altered Expression	[11]
FDPS	TTIKWV4	Limited	Biomarker	[12]
FES	TTLBY21	Limited	Biomarker	[12]
MAPKAP1	TTWDKCL	Limited	Biomarker	[13]
NFE2L2	TTA6ZN2	Limited	Biomarker	[14]
NOS2	TTF10I9	Limited	Biomarker	[15]
NOS3	TTCM4B3	Limited	Genetic Variation	[16]
NRN1	TTS05MJ	Limited	Biomarker	[17]
RPS6KA5	TTYXEPL	Limited	Biomarker	[18]
RXFP1	TTMAHD1	Limited	Altered Expression	[19]
SSRP1	TTETDKQ	Limited	Biomarker	[20]
TLR4	TTISGCA	Limited	Biomarker	[21]
TNC	TTUCPMY	Limited	Biomarker	[22]
GRIA1	TTVPQTF	Disputed	Biomarker	[23]
AGER	TTMO9HF	moderate	Altered Expression	[24]
HMGB1	TTWQYB7	moderate	Altered Expression	[25]
HP	TTLC8E1	moderate	Genetic Variation	[26]
MPO	TTVCZPI	moderate	Biomarker	[27]
ABCC8	TTP835K	Strong	Biomarker	[28]
AIF1	TT12MEP	Strong	Biomarker	[29]
ATF4	TTQCKWT	Strong	Biomarker	[30]
BECN1	TT5M7LN	Strong	Biomarker	[31]
C3	TTJGY7A	Strong	Therapeutic	[32]
CALCA	TTVSFJW	Strong	Biomarker	[33]
CCL20	TT2XAZY	Strong	Biomarker	[34]
CXCL1	TTLK1RW	Strong	Biomarker	[35]
DAPK3	TTERVQN	Strong	Altered Expression	[36]
ESR1	TTZAYWL	Strong	Biomarker	[37]
F3	TT38MDJ	Strong	Genetic Variation	[38]
GLI1	TTJOMH6	Strong	Biomarker	[39]
GSK3B	TTRSMW9	Strong	Biomarker	[40]
HCN1	TTNB6UQ	Strong	Biomarker	[41]
HSPD1	TT9HL5R	Strong	Biomarker	[42]
HTR1B	TTK8CXU	Strong	Biomarker	[43]
ICAM1	TTA1L39	Strong	Biomarker	[44]
KCNJ10	TTG140O	Strong	Therapeutic	[45]
MMP13	TTHY57M	Strong	Biomarker	[46]
MMP2	TTLM12X	Strong	Biomarker	[47]
MYLK	TT18ETS	Strong	Biomarker	[48]
NQO1	TT8XK6L	Strong	Biomarker	[49]
NTRK2	TTKN7QR	Strong	Biomarker	[50]
PCSK1	TTED9LZ	Strong	Biomarker	[51]
POSTN	TT8ALTZ	Strong	Altered Expression	[52]
RALBP1	TTVSRUA	Strong	Altered Expression	[53]
ROCK2	TTGWKQJ	Strong	Biomarker	[54]
SHH	TTIENCJ	Strong	Biomarker	[39]
SORD	TTLSRBZ	Strong	Biomarker	[55]
TACR1	TTZPO1L	Strong	Biomarker	[43]
TBL1X	TTAL6S1	Strong	Biomarker	[56]
TMBIM6	TT7QSMG	Strong	Biomarker	[57]
TRPM4	TTJ2HKA	Strong	Biomarker	[58]
TXNIP	TTTLDZK	Strong	Altered Expression	[59]
UCP3	TT12RJK	Strong	Genetic Variation	[60]
UTRN	TTNO1VA	Strong	Biomarker	[61]
UTS2	TTERU0T	Strong	Altered Expression	[62]
APLN	TT87D3J	Definitive	Biomarker	[63]
APLNR	TTJ8E43	Definitive	Altered Expression	[64]
C5	TTKANGO	Definitive	Biomarker	[65]
CBS	TTVZJ7G	Definitive	Genetic Variation	[66]
DDIT4	TTVEOY6	Definitive	Biomarker	[67]
GAP43	TTSGLN5	Definitive	Biomarker	[68]
GFAP	TTI6FFX	Definitive	Altered Expression	[69]
GRM1	TTVBPDM	Definitive	Biomarker	[70]
MANF	TT56RYE	Definitive	Altered Expression	[71]
MASP2	TTR01E9	Definitive	Biomarker	[72]
NTN1	TT0AH4L	Definitive	Biomarker	[73]
PLA2G7	TTDNFMT	Definitive	Biomarker	[74]
PPARG	TTT2SVW	Definitive	Altered Expression	[75]
RIPK1	TTVJHX8	Definitive	Biomarker	[76]
RNPEP	TTD74YX	Definitive	Biomarker	[77]
RYR1	TTU5CIX	Definitive	Genetic Variation	[78]
S100A12	TTQ4ESF	Definitive	Biomarker	[33]
S1PR4	TTZ8C5Q	Definitive	Biomarker	[79]
SIRT3	TTVZLIJ	Definitive	Altered Expression	[80]
TNFSF12	TTBTDM1	Definitive	Biomarker	[81]
TREM1	TTHZQP0	Definitive	Biomarker	[82]
TRIM27	TTTO3QN	Definitive	Biomarker	[83]
UGCG	TTPHEX3	Definitive	Biomarker	[84]
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⏷ Show the Full List of 84 DTT(s)

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC30A3	DTKMECW	Limited	Biomarker	[85]
SLC25A15	DTHEMTY	Disputed	Biomarker	[86]
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This Disease Is Related to 4 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
MARS1	DE0K52I	Limited	Biomarker	[87]
CRMP1	DE0EUXB	Strong	Biomarker	[61]
GCLC	DESYL1F	Definitive	Biomarker	[84]
MMEL1	DEYCUQ2	Definitive	Biomarker	[88]
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This Disease Is Related to 84 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
APPL1	OT8VR95S	Limited	Biomarker	[89]
CLDN3	OT71MN9S	Limited	Altered Expression	[90]
CXCL3	OTSL94KH	Limited	Biomarker	[91]
DBP	OTE0W7LN	Limited	Biomarker	[92]
ECI1	OTRQTK84	Limited	Biomarker	[93]
ECSCR	OT9L72MD	Limited	Biomarker	[94]
ERLIN1	OTUOOODY	Limited	Genetic Variation	[13]
HAP1	OT6SG0JQ	Limited	Genetic Variation	[95]
ITM2C	OTHVMXE3	Limited	Biomarker	[13]
KAT2A	OTN0W2SW	Limited	Altered Expression	[96]
MAP3K12	OT5HODDD	Limited	Biomarker	[36]
MAPK8IP3	OT0X8ACY	Limited	Biomarker	[36]
MNT	OTPC4ANL	Limited	Biomarker	[97]
MRS2	OTICD11V	Limited	Biomarker	[98]
NEXN	OTKB0B0H	Limited	Biomarker	[99]
NGEF	OT9QUXJ3	Limited	Altered Expression	[11]
PANX1	OTXPEDOK	Limited	Altered Expression	[100]
PCMT1	OTGYVSGU	Limited	Biomarker	[101]
PELI1	OTMLBCLC	Limited	Altered Expression	[102]
RIOX1	OTN41QXP	Limited	Biomarker	[97]
RIOX2	OT2YFPI2	Limited	Biomarker	[97]
SLA2	OTNVE666	Limited	Biomarker	[87]
TRAPPC9	OTF0CVMC	Limited	Genetic Variation	[13]
AGGF1	OTA7U2T8	Disputed	Altered Expression	[103]
CRYGD	OTW29JC4	Disputed	Biomarker	[104]
HSPB6	OTFPLGZI	Disputed	Biomarker	[105]
LRPAP1	OT6DVD2Q	Disputed	Biomarker	[106]
MOCOS	OT0TL3Q5	Disputed	Altered Expression	[107]
MPG	OTAHW80B	Disputed	Biomarker	[108]
PPP6R3	OTIXD60Q	Disputed	Biomarker	[109]
PRRX2	OT8UR4AU	Disputed	Biomarker	[110]
SMCP	OTXKY794	Disputed	Altered Expression	[107]
SPTAN1	OT6VY3A3	Disputed	Biomarker	[111]
ST8SIA2	OTRBBBD8	Disputed	Biomarker	[112]
ACSM3	OT0AE1IV	moderate	Biomarker	[113]
THSD1	OTKPGFHS	moderate	Genetic Variation	[114]
AQP4	OTA9MYD5	Strong	Altered Expression	[115]
BNIP3	OT4SO7J4	Strong	Therapeutic	[116]
CLDN5	OTUX60YO	Strong	Biomarker	[14]
CLEC4E	OT7P8ICY	Strong	Biomarker	[117]
COL3A1	OTT1EMLM	Strong	Genetic Variation	[118]
DAPK2	OTWODUQG	Strong	Biomarker	[61]
DENR	OTXP9HOY	Strong	Biomarker	[61]
ELN	OTFSO7PG	Strong	Genetic Variation	[119]
FCN1	OTK6ZHXH	Strong	Altered Expression	[120]
INTU	OTXB13E6	Strong	Biomarker	[121]
MPRIP	OT5FV5NS	Strong	Biomarker	[122]
MST1	OTOC4UNG	Strong	Biomarker	[123]
NEFL	OTQESJV4	Strong	Biomarker	[124]
NGB	OTW0SIUY	Strong	Altered Expression	[125]
NLK	OT2LETFS	Strong	ModifyingMutation	[126]
OCLN	OTSUTVWL	Strong	Altered Expression	[127]
OR10A4	OTYYB8SY	Strong	Genetic Variation	[128]
PHB2	OTCAX3AW	Strong	Biomarker	[14]
PKD1	OT5ALRZ5	Strong	Genetic Variation	[129]
PRKN	OTJBN41W	Strong	Therapeutic	[130]
PTCH1	OTMG07H5	Strong	Biomarker	[39]
RIPK3	OTL1D484	Strong	Biomarker	[122]
SARDH	OTQ49Q27	Strong	Biomarker	[55]
SDHB	OTRE1M1T	Strong	Biomarker	[55]
SDS	OT5WTJ2M	Strong	Biomarker	[55]
TJP1	OTBDCUPK	Strong	Altered Expression	[52]
ANXA7	OTLMD0TK	Definitive	Biomarker	[131]
APBB3	OTNUTR0N	Definitive	Biomarker	[132]
BTBD8	OT3A3RD7	Definitive	Biomarker	[133]
CCL13	OTNX0JD0	Definitive	Genetic Variation	[134]
DNM1L	OTXK1Q1G	Definitive	Biomarker	[135]
FCN3	OTPRENLS	Definitive	Altered Expression	[120]
HPX	OT14T7Q1	Definitive	Biomarker	[136]
IRF9	OTK4MYQJ	Definitive	Altered Expression	[137]
LYPD4	OTYNO8BS	Definitive	Genetic Variation	[138]
MAP2	OT6UYT3X	Definitive	Biomarker	[139]
MASP1	OTWWCNZP	Definitive	Biomarker	[120]
NEFH	OTMSCW5I	Definitive	Biomarker	[140]
NET1	OTZHNMJV	Definitive	Biomarker	[141]
PDP1	OT82RTMT	Definitive	Biomarker	[142]
PLXNB1	OTCA7JIT	Definitive	Biomarker	[88]
POLDIP3	OTTB5SV7	Definitive	Altered Expression	[52]
PRRX1	OTTZK5G8	Definitive	Altered Expression	[143]
RAB34	OTHKTSA0	Definitive	Biomarker	[144]
ROMO1	OTIEYVBW	Definitive	Biomarker	[145]
SCARA5	OTOVA96E	Definitive	Genetic Variation	[81]
SYN1	OTMNPWC1	Definitive	Biomarker	[68]
TSPAN33	OTH6C0WU	Definitive	Biomarker	[88]
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⏷ Show the Full List of 84 DOT(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	ClinicalTrials.gov (NCT02614742) SFX-01 After Subarachnoid Haemorrhage (SAS). U.S. National Institutes of Health.
4	Deferoxamine FDA Label
5	Attenuation of cerebral vasospasm and secondary injury by 17beta-estradiol following experimental subarachnoid hemorrhage.J Neurosurg. 2009 Mar;110(3):457-61. doi: 10.3171/2008.6.17622.
6	Adrenoceptor polymorphisms and the risk of cardiac injury and dysfunction after subarachnoid hemorrhage.Stroke. 2006 Jul;37(7):1680-5. doi: 10.1161/01.STR.0000226461.52423.dd. Epub 2006 May 25.
7	Hypothesis on the Role of Cryptochromes in Inflammation and Subarachnoid Hemorrhage Outcome.Front Neurol. 2017 Nov 28;8:637. doi: 10.3389/fneur.2017.00637. eCollection 2017.
8	Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage.Stroke. 2005 Apr;36(4):737-40. doi: 10.1161/01.STR.0000157598.02014.37. Epub 2005 Feb 17.
9	MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats.PLoS One. 2019 Apr 12;14(4):e0215398. doi: 10.1371/journal.pone.0215398. eCollection 2019.
10	A novel multicolor flow-cytometry application for quantitative detection of receptors on vascular smooth muscle cells.PLoS One. 2017 Oct 30;12(10):e0186504. doi: 10.1371/journal.pone.0186504. eCollection 2017.
11	Critical role of EphA4 in early brain injury after subarachnoid hemorrhage in rat.Exp Neurol. 2017 Oct;296:41-48. doi: 10.1016/j.expneurol.2017.07.003. Epub 2017 Jul 8.
12	HMGB1 promotes neurovascular remodeling via Rage in the late phase of subarachnoid hemorrhage.Brain Res. 2017 Sep 1;1670:135-145. doi: 10.1016/j.brainres.2017.06.001. Epub 2017 Jun 9.
13	Association of genetic variants with hemorrhagic stroke in Japanese individuals.Int J Mol Med. 2010 Apr;25(4):649-56. doi: 10.3892/ijmm_00000388.
14	Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats.Exp Neurol. 2019 Jul;317:1-9. doi: 10.1016/j.expneurol.2019.02.009. Epub 2019 Feb 16.
15	The role of constitutive and inducible nitric oxide synthase in the human brain after subarachnoid hemorrhage.J Neurosurg Sci. 2007 Mar;51(1):1-9.
16	The Correlation of Endothelial Nitric Oxide Synthase (eNOS) Polymorphism and Other Risk Factors with Aneurysmal Subarachnoid Hemorrhage: A Case-Control Study.Neurol India. 2019 Jul-Aug;67(4):1006-1012. doi: 10.4103/0028-3886.266231.
17	Neuritin attenuates early brain injury in rats after experimental subarachnoid hemorrhage.Int J Neurosci. 2017 Dec;127(12):1087-1095. doi: 10.1080/00207454.2017.1337013. Epub 2017 Jun 14.
18	MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats.Oncol Lett. 2017 Sep;14(3):2940-2946. doi: 10.3892/ol.2017.6496. Epub 2017 Jun 30.
19	Upregulation of relaxin after experimental subarachnoid hemorrhage in rabbits.Biomed Res Int. 2014;2014:836397. doi: 10.1155/2014/836397. Epub 2014 Jul 16.
20	Elucidating novel mechanisms of brain injury following subarachnoid hemorrhage: an emerging role for neuroproteomics.Neurosurg Focus. 2010 Jan;28(1):E10. doi: 10.3171/2009.10.FOCUS09223.
21	The role of TLR4 and HO-1 in neuroinflammation after subarachnoid hemorrhage.J Neurosci Res. 2020 Mar;98(3):549-556. doi: 10.1002/jnr.24515. Epub 2019 Aug 29.
22	Tenascin-C in brain injuries and edema after subarachnoid hemorrhage: Findings from basic and clinical studies.J Neurosci Res. 2020 Jan;98(1):42-56. doi: 10.1002/jnr.24330. Epub 2018 Sep 22.
23	Effect of Progesterone on Cerebral Vasospasm and Neurobehavioral Outcomes in a Rodent Model of Subarachnoid Hemorrhage.World Neurosurg. 2018 Feb;110:e150-e159. doi: 10.1016/j.wneu.2017.10.118. Epub 2017 Oct 31.
24	Soluble receptor for advanced glycation end products as a biomarker of symptomatic vasospasm in subarachnoid hemorrhage.J Neurosurg. 2019 Nov 1;134(1):122-130. doi: 10.3171/2019.8.JNS191269.
25	Exosomes from Bone Marrow Mesenchymal Stem Cells Can Alleviate Early Brain Injury After Subarachnoid Hemorrhage Through miRNA129-5p-HMGB1 Pathway.Stem Cells Dev. 2020 Feb 15;29(4):212-221. doi: 10.1089/scd.2019.0206. Epub 2019 Dec 30.
26	Haptoglobin genotype and aneurysmal subarachnoid hemorrhage: Individual patient data analysis.Neurology. 2019 Apr 30;92(18):e2150-e2164. doi: 10.1212/WNL.0000000000007397. Epub 2019 Apr 5.
27	LXA4 ameliorates cerebrovascular endothelial dysfunction by reducing acute inflammation after subarachnoid hemorrhage in rats.Neuroscience. 2019 Jun 1;408:105-114. doi: 10.1016/j.neuroscience.2019.03.038. Epub 2019 Mar 22.
28	Sulfonylurea receptor 1 expression is variable in adult and pediatric brain tumors.Clin Neuropathol. 2018 Sep/Oct;37(5):221-227. doi: 10.5414/NP301102.
29	Activation of epiplexus macrophages in hydrocephalus caused by subarachnoid hemorrhage and thrombin.CNS Neurosci Ther. 2019 Oct;25(10):1134-1141. doi: 10.1111/cns.13203. Epub 2019 Aug 21.
30	Tauroursodeoxycholic acid prevents ER stress-induced apoptosis and improves cerebral and vascular function in mice subjected to subarachnoid hemorrhage.Brain Res. 2020 Jan 15;1727:146566. doi: 10.1016/j.brainres.2019.146566. Epub 2019 Nov 25.
31	Inhibition of BECN1 Suppresses Lipid Peroxidation by Increasing System X(c)(-) Activity in Early Brain Injury after Subarachnoid Hemorrhage.J Mol Neurosci. 2019 Apr;67(4):622-631. doi: 10.1007/s12031-019-01272-5. Epub 2019 Feb 4.
32	Protective effects of Ephedra sinica extract on blood-brain barrier integrity and neurological function correlate with complement C3 reduction after subarachnoid hemorrhage in rats.Neurosci Lett. 2015 Nov 16;609:216-22. doi: 10.1016/j.neulet.2015.10.056. Epub 2015 Oct 27.
33	Vascular pathology of large cerebral arteries in experimental subarachnoid hemorrhage: Vasoconstriction, functional CGRP depletion and maintained CGRP sensitivity.Eur J Pharmacol. 2019 Mar 5;846:109-118. doi: 10.1016/j.ejphar.2019.01.007. Epub 2019 Jan 14.
34	Transcriptional regulation of inflammatory and extracellular matrix-regulating genes in cerebral arteries following experimental subarachnoid hemorrhage in rats. Laboratory investigation.J Neurosurg. 2007 Nov;107(5):1015-22. doi: 10.3171/JNS-07/11/1015.
35	Interferon- attenuates lung inflammation following experimental subarachnoid hemorrhage.Crit Care. 2010;14(4):R157. doi: 10.1186/cc9232. Epub 2010 Aug 23.
36	DLK silencing attenuated neuron apoptosis through JIP3/MA2K7/JNK pathway in early brain injury after SAH in rats.Neurobiol Dis. 2017 Jul;103:133-143. doi: 10.1016/j.nbd.2017.04.006. Epub 2017 Apr 8.
37	17-Estradiol attenuates secondary injury through activation of Akt signaling via estrogen receptor alpha in rat brain following subarachnoid hemorrhage.J Surg Res. 2013 Jul;183(1):e23-30. doi: 10.1016/j.jss.2013.01.033. Epub 2013 Feb 8.
38	Intrathecal administration of nusinersen in adult and adolescent patients with spinal muscular atrophy and scoliosis: Transforaminal versus conventional approach.Neuromuscul Disord. 2019 Oct;29(10):742-746. doi: 10.1016/j.nmd.2019.08.007. Epub 2019 Aug 23.
39	The role of the sonic hedgehog signaling pathway in early brain injury after experimental subarachnoid hemorrhage in rats.Neurosci Lett. 2013 Sep 27;552:81-6. doi: 10.1016/j.neulet.2013.07.042. Epub 2013 Aug 7.
40	Apolipoprotein E-Mimetic Peptide COG1410 Promotes Autophagy by Phosphorylating GSK-3 in Early Brain Injury Following Experimental Subarachnoid Hemorrhage.Front Neurosci. 2018 Mar 5;12:127. doi: 10.3389/fnins.2018.00127. eCollection 2018.
41	Role of HCN channels in neuronal hyperexcitability after subarachnoid hemorrhage in rats.J Neurosci. 2012 Feb 29;32(9):3164-75. doi: 10.1523/JNEUROSCI.5143-11.2012.
42	Heat shock proteins expression in brain stem after subarachnoid hemorrhage in rats.Acta Neurochir Suppl. 2003;86:477-82. doi: 10.1007/978-3-7091-0651-8_98.
43	Neurokinin-1 receptor antagonism in a rat model of subarachnoid hemorrhage: prevention of upregulation of contractile ETB and 5-HT1B receptors and cerebral blood flow reduction.J Neurosurg. 2007 May;106(5):881-6. doi: 10.3171/jns.2007.106.5.881.
44	Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPAR/NFB signaling pathway after subarachnoid hemorrhage in rats. Brain Behav Immun. 2018 Mar;69:190-202. doi: 10.1016/j.bbi.2017.11.012. Epub 2017 Nov 21.
45	p53-induced uncoupling expression of aquaporin-4 and inwardly rectifying K+ 4.1 channels in cytotoxic edema after subarachnoid hemorrhage.CNS Neurosci Ther. 2012 Apr;18(4):334-42. doi: 10.1111/j.1755-5949.2012.00299.x. Epub 2012 Mar 15.
46	Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in the rat.J Neurosurg. 2006 Sep;105(3):438-44. doi: 10.3171/jns.2006.105.3.438.
47	High Serum Level of Matrix Metalloproteinase-7 Is Associated With Increased Risk of Spontaneous Subarachnoid Hemorrhage.Stroke. 2018 Jul;49(7):1626-1631. doi: 10.1161/STROKEAHA.118.020660. Epub 2018 Jun 7.
48	Inhibition of human immunodeficiency virus type 1 replication by a bioavailable serine/threonine kinase inhibitor, fasudil hydrochloride.AIDS Res Hum Retroviruses. 1998 Mar 1;14(4):293-8. doi: 10.1089/aid.1998.14.293.
49	Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage.J Neurosci Res. 2011 Apr;89(4):515-23. doi: 10.1002/jnr.22577. Epub 2011 Jan 21.
50	Preservation of tropomyosin-related kinase B (TrkB) signaling by sodium orthovanadate attenuates early brain injury after subarachnoid hemorrhage in rats.Stroke. 2011 Feb;42(2):477-83. doi: 10.1161/STROKEAHA.110.597344. Epub 2010 Dec 30.
51	Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway.Front Neurosci. 2019 Jan 7;12:990. doi: 10.3389/fnins.2018.00990. eCollection 2018.
52	Selective Toll-Like Receptor 4 Antagonists Prevent Acute Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice.Mol Neurobiol. 2019 Feb;56(2):976-985. doi: 10.1007/s12035-018-1145-2. Epub 2018 May 31.
53	RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage.Exp Neurol. 2017 Sep;295:116-124. doi: 10.1016/j.expneurol.2017.06.003. Epub 2017 Jun 2.
54	ROCK2 regulates autophagy in the hippocampus of rats after subarachnoid hemorrhage.Neuroreport. 2018 Dec 12;29(18):1571-1577. doi: 10.1097/WNR.0000000000001154.
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56	Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage.Front Neurosci. 2019 Nov 15;13:1223. doi: 10.3389/fnins.2019.01223. eCollection 2019.
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