Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTLQ6P8R)

DOT Name Serine/threonine-protein kinase 11-interacting protein (STK11IP)
Synonyms LKB1-interacting protein 1
Gene Name STK11IP
Related Disease
Lung cancer ( )
Lung carcinoma ( )
Neoplasm ( )
Carcinoma ( )
Adenocarcinoma ( )
Peutz-Jeghers syndrome ( )
UniProt ID
S11IP_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF15904
Sequence
MTTAQRDSLLWKLAGLLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHLGPWGPGQTGFV
ALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGPGPTGPIKIFPFKSLRHLELRGVPL
HCLHGLRGIYSQLETLICSRSLQALEELLSACGGDFCSALPWLALLSANFSYNALTALDS
SLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLILR
GNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGNPLWFHPEHRAA
TAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPPLPWPVGSTPETSGGPDLS
DSLSSGGVVTQPLLHKVKSRVRVRRASISEPSDTDPEPRTLNPSPAGWFVQQHPELELMS
SFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQ
ESPQKMSEEVRAEPQEEEEEKEGKEEKEEGEMVEQGEEEAGEEEEEEQDQKEVEAELCRP
LLVCPLEGPEGVRGRECFLRVTSAHLFEVELQAARTLERLELQSLEAAEIEPEAQAQRSP
RPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLTPVTNVAREQLG
EARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTESPAVCPNCGSDHVVLLAV
SRGTPNRERKQGEQSLAPSPSASPVCHPPGHGDHLDRAKNSPPQAPSTRDHGSWSLSPPP
ERCGLRSVDHRLRLFLDVEVFSDAQEEFQCCLKVPVALAGHTGEFMCLVVVSDRRLYLLK
VTGEMREPPASWLQLTLAVPLQDLSGIELGLAGQSLRLEWAAGAGRCVLLPRDARHCRAF
LEELLDVLQSLPPAWRNCVSATEEEVTPQHRLWPLLEKDSSLEARQFFYLRAFLVEGPST
CLVSLLLTPSTLFLLDEDAAGSPAEPSPPAASGEASEKVPPSGPGPAVRVREQQPLSSLS
SVLLYRSAPEDLRLLFYDEVSRLESFWALRVVCQEQLTALLAWIREPWEELFSIGLRTVI
QEALALDR
Function May regulate STK11/LKB1 function by controlling its subcellular localization.
Reactome Pathway
Neutrophil degranulation (R-HSA-6798695 )

Molecular Interaction Atlas (MIA) of This DOT

6 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Lung cancer DISCM4YA Definitive Biomarker [1]
Lung carcinoma DISTR26C Definitive Biomarker [1]
Neoplasm DISZKGEW Strong Biomarker [2]
Carcinoma DISH9F1N moderate Biomarker [3]
Adenocarcinoma DIS3IHTY Limited Altered Expression [4]
Peutz-Jeghers syndrome DISF27ZJ Limited Biomarker [5]
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⏷ Show the Full List of 6 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
4 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the expression of Serine/threonine-protein kinase 11-interacting protein (STK11IP). [6]
Doxorubicin DMVP5YE Approved Doxorubicin decreases the expression of Serine/threonine-protein kinase 11-interacting protein (STK11IP). [7]
Cisplatin DMRHGI9 Approved Cisplatin decreases the expression of Serine/threonine-protein kinase 11-interacting protein (STK11IP). [8]
Decitabine DMQL8XJ Approved Decitabine affects the expression of Serine/threonine-protein kinase 11-interacting protein (STK11IP). [9]
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2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
PMID28870136-Compound-52 DMFDERP Patented PMID28870136-Compound-52 decreases the phosphorylation of Serine/threonine-protein kinase 11-interacting protein (STK11IP). [10]
Coumarin DM0N8ZM Investigative Coumarin decreases the phosphorylation of Serine/threonine-protein kinase 11-interacting protein (STK11IP). [10]
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References

1 Typing tumors using pathways selected by somatic evolution.Nat Commun. 2018 Oct 8;9(1):4159. doi: 10.1038/s41467-018-06464-y.
2 EWSR1 genetic rearrangements in salivary gland tumors: a specific and very common feature of hyalinizing clear cell carcinoma.Am J Surg Pathol. 2013 Apr;37(4):571-8. doi: 10.1097/PAS.0b013e3182772a15.
3 STRAD in Peutz-Jeghers syndrome and sporadic cancers.J Clin Pathol. 2005 Oct;58(10):1091-5. doi: 10.1136/jcp.2005.026013.
4 Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.Hum Pathol. 2007 Sep;38(9):1351-60. doi: 10.1016/j.humpath.2007.01.022. Epub 2007 May 22.
5 Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2.Cytogenet Genome Res. 2002;97(3-4):171-8. doi: 10.1159/000066620.
6 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
7 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
8 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
9 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
10 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.