Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTVU4B6B)

DOT Name	Protein DPCD (DPCD)
Gene Name	DPCD
Related Disease	Hydrocephalus ( )
UniProt ID	DPCD_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF14913
Sequence	MAVTGWLESLRTAQKTALLQDGRRKVHYLFPDGKEMAEEYDEKTSELLVRKWRVKSALGA MGQWQLEVGDPAPLGAGNLGPELIKESNANPIFMRKDTKMSFQWRIRNLPYPKDVYSVSV DQKERCIIVRTTNKKYYKKFSIPDLDRHQLPLDDALLSFAHANCTLIISYQKPKEVVVAE SELQKELKKVKTAHSNDGDCKTQ
Function	May play a role in the formation or function of ciliated cells.
Tissue Specificity	Highly expressed in the testis. Weakly expressed in pancreas, skeletal muscle and heart. Expression increases during ciliated cell differentiation.

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance		REF
Hydrocephalus	DISIZUF7	Strong	Biomarker	[1]
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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DOT

9 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the expression of Protein DPCD (DPCD).	[2]
Ciclosporin	DMAZJFX	Approved	Ciclosporin decreases the expression of Protein DPCD (DPCD).	[3]
Doxorubicin	DMVP5YE	Approved	Doxorubicin increases the expression of Protein DPCD (DPCD).	[4]
Cupric Sulfate	DMP0NFQ	Approved	Cupric Sulfate decreases the expression of Protein DPCD (DPCD).	[5]
Ivermectin	DMDBX5F	Approved	Ivermectin decreases the expression of Protein DPCD (DPCD).	[6]
Temozolomide	DMKECZD	Approved	Temozolomide decreases the expression of Protein DPCD (DPCD).	[7]
Urethane	DM7NSI0	Phase 4	Urethane decreases the expression of Protein DPCD (DPCD).	[8]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A affects the expression of Protein DPCD (DPCD).	[9]
Milchsaure	DM462BT	Investigative	Milchsaure decreases the expression of Protein DPCD (DPCD).	[10]
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⏷ Show the Full List of 9 Drug(s)

References

1	Congenital hydrocephalus in genetically engineered mice.Vet Pathol. 2012 Jan;49(1):166-81. doi: 10.1177/0300985811415708. Epub 2011 Jul 11.
2	Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
3	Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
4	Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
5	Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
6	Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
7	Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
8	Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
9	Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
10	Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.