Details of the Drug Combination

General Information of Drug Combination (ID: DC8CIQ3)

Drug Combination Name
NAFTOPIDIL Aceclofenac
Indication
Disease Entry Status REF
Disorder of Urinary Stent Phase 3 [1]
Component Drugs NAFTOPIDIL   DMQ8R4E Aceclofenac   DMZDF0B
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of NAFTOPIDIL
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Approved [2]
NAFTOPIDIL Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Adrenergic receptor alpha-1A (ADRA1A) TTNGILX ADA1A_HUMAN Inhibitor [3]
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NAFTOPIDIL Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [4]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [4]
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NAFTOPIDIL Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [5]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Affects Expression [5]
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Indication(s) of Aceclofenac
Disease Entry ICD 11 Status REF
Inflammation 1A00-CA43.1 Approved [2]
Aceclofenac Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Modulator [6]
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Aceclofenac Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [7]
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Aceclofenac Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
L-selectin (SELL) OT6RAJZR LYAM1_HUMAN Decreases Expression [8]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [9]
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References

1 ClinicalTrials.gov (NCT01959074) The Effect of Naftopidil for the Double-J Stent Discomfort
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64.
4 Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro. J Pharm Pharmacol. 2014 Nov;66(11):1534-51.
5 Autophagy Induced by Naftopidil Inhibits Apoptosis of Human Gastric Cancer Cells. Anticancer Res. 2018 Feb;38(2):803-809. doi: 10.21873/anticanres.12287.
6 Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac. Clin Pharmacol Ther. 2003 Sep;74(3):222-35.
7 Metabolism of aceclofenac in humans. Drug Metab Dispos. 1996 Aug;24(8):834-41.
8 Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. J Biol Chem. 2002 Oct 11;277(41):38212-21. doi: 10.1074/jbc.M205142200. Epub 2002 Jul 29.
9 Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. Biochem Biophys Res Commun. 2004 Dec 24;325(4):1298-303. doi: 10.1016/j.bbrc.2004.10.176.