Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTUYHB84)

DOT Name Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Synonyms
Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light chain 3 beta
Gene Name MAP1LC3B
Related Disease
Rheumatoid arthritis ( )
Type-1/2 diabetes ( )
Adenocarcinoma ( )
Alzheimer disease ( )
Astrocytoma ( )
B-cell neoplasm ( )
Bone osteosarcoma ( )
Carcinoma ( )
Colon cancer ( )
Colon carcinoma ( )
Colorectal carcinoma ( )
Diabetic retinopathy ( )
Epithelial ovarian cancer ( )
Gastric cancer ( )
Glioma ( )
Hepatitis C virus infection ( )
Hepatocellular carcinoma ( )
Medullary thyroid gland carcinoma ( )
Myocardial ischemia ( )
Oral lichen planus ( )
Osteoarthritis ( )
Osteosarcoma ( )
Ovarian cancer ( )
Ovarian neoplasm ( )
Parkinson disease ( )
Prostate cancer ( )
Prostate carcinoma ( )
Stomach cancer ( )
Systemic lupus erythematosus ( )
Breast cancer ( )
Breast carcinoma ( )
Invasive breast carcinoma ( )
Non-small-cell lung cancer ( )
Pulmonary fibrosis ( )
Renal cell carcinoma ( )
Triple negative breast cancer ( )
Urinary bladder neoplasm ( )
Adult glioblastoma ( )
Advanced cancer ( )
Breast neoplasm ( )
Clear cell renal carcinoma ( )
Glioblastoma multiforme ( )
Melanoma ( )
Metastatic malignant neoplasm ( )
Neuroblastoma ( )
UniProt ID
MLP3B_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
PDB ID
1V49; 2LUE; 2N9X; 2ZJD; 3VTU; 3VTV; 3VTW; 3WAO; 3X0W; 4WAA; 5D94; 5DCN; 5GMV; 5MS2; 5MS5; 5MS6; 5V4K; 5W9A; 5XAC; 5XAD; 5XAE; 6J04; 6LAN; 7ELG
Pfam ID
PF02991
Sequence
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFG
MKLSV
Function
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Upon nutrient stress, directly recruits cofactor JMY to the phagophore membrane surfaces and promotes JMY's actin nucleation activity and autophagosome biogenesis during autophagy.
Tissue Specificity Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver.
KEGG Pathway
Mitophagy - animal (hsa04137 )
Autophagy - animal (hsa04140 )
Ferroptosis (hsa04216 )
Apelin sig.ling pathway (hsa04371 )
NOD-like receptor sig.ling pathway (hsa04621 )
Amyotrophic lateral sclerosis (hsa05014 )
Pathways of neurodegeneration - multiple diseases (hsa05022 )
Shigellosis (hsa05131 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Reactome Pathway
PINK1-PRKN Mediated Mitophagy (R-HSA-5205685 )
TBC/RABGAPs (R-HSA-8854214 )
Receptor Mediated Mitophagy (R-HSA-8934903 )
Pexophagy (R-HSA-9664873 )
Translation of Replicase and Assembly of the Replication Transcription Complex (R-HSA-9679504 )
Translation of Replicase and Assembly of the Replication Transcription Complex (R-HSA-9694676 )
SARS-CoV-2 modulates autophagy (R-HSA-9754560 )
KEAP1-NFE2L2 pathway (R-HSA-9755511 )
Macroautophagy (R-HSA-1632852 )

Molecular Interaction Atlas (MIA) of This DOT

45 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Rheumatoid arthritis DISTSB4J Definitive Genetic Variation [1]
Type-1/2 diabetes DISIUHAP Definitive Altered Expression [2]
Adenocarcinoma DIS3IHTY Strong Biomarker [3]
Alzheimer disease DISF8S70 Strong Altered Expression [4]
Astrocytoma DISL3V18 Strong Biomarker [5]
B-cell neoplasm DISVY326 Strong Altered Expression [6]
Bone osteosarcoma DIST1004 Strong Altered Expression [7]
Carcinoma DISH9F1N Strong Altered Expression [8]
Colon cancer DISVC52G Strong Biomarker [9]
Colon carcinoma DISJYKUO Strong Biomarker [9]
Colorectal carcinoma DIS5PYL0 Strong Biomarker [10]
Diabetic retinopathy DISHGUJM Strong Altered Expression [11]
Epithelial ovarian cancer DIS56MH2 Strong Biomarker [12]
Gastric cancer DISXGOUK Strong Altered Expression [13]
Glioma DIS5RPEH Strong Biomarker [14]
Hepatitis C virus infection DISQ0M8R Strong Altered Expression [15]
Hepatocellular carcinoma DIS0J828 Strong Biomarker [16]
Medullary thyroid gland carcinoma DISHBL3K Strong Altered Expression [17]
Myocardial ischemia DISFTVXF Strong Biomarker [18]
Oral lichen planus DISVEAJA Strong Altered Expression [19]
Osteoarthritis DIS05URM Strong Biomarker [20]
Osteosarcoma DISLQ7E2 Strong Altered Expression [7]
Ovarian cancer DISZJHAP Strong Biomarker [12]
Ovarian neoplasm DISEAFTY Strong Biomarker [12]
Parkinson disease DISQVHKL Strong Biomarker [21]
Prostate cancer DISF190Y Strong Biomarker [22]
Prostate carcinoma DISMJPLE Strong Biomarker [22]
Stomach cancer DISKIJSX Strong Altered Expression [13]
Systemic lupus erythematosus DISI1SZ7 Strong Biomarker [23]
Breast cancer DIS7DPX1 moderate Biomarker [24]
Breast carcinoma DIS2UE88 moderate Biomarker [24]
Invasive breast carcinoma DISANYTW moderate Biomarker [25]
Non-small-cell lung cancer DIS5Y6R9 moderate Altered Expression [26]
Pulmonary fibrosis DISQKVLA moderate Biomarker [27]
Renal cell carcinoma DISQZ2X8 moderate Biomarker [28]
Triple negative breast cancer DISAMG6N moderate Biomarker [25]
Urinary bladder neoplasm DIS7HACE moderate Altered Expression [29]
Adult glioblastoma DISVP4LU Limited Altered Expression [30]
Advanced cancer DISAT1Z9 Limited Genetic Variation [31]
Breast neoplasm DISNGJLM Limited Altered Expression [32]
Clear cell renal carcinoma DISBXRFJ Limited Biomarker [28]
Glioblastoma multiforme DISK8246 Limited Altered Expression [30]
Melanoma DIS1RRCY Limited Altered Expression [33]
Metastatic malignant neoplasm DIS86UK6 Limited Biomarker [34]
Neuroblastoma DISVZBI4 Limited Altered Expression [35]
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⏷ Show the Full List of 45 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 2 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Fluorouracil DMUM7HZ Approved Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) affects the response to substance of Fluorouracil. [111]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Approved Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) increases the response to substance of Eicosapentaenoic acid/docosa-hexaenoic acid. [112]
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68 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [36]
Ciclosporin DMAZJFX Approved Ciclosporin increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [37]
Tretinoin DM49DUI Approved Tretinoin increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [38]
Acetaminophen DMUIE76 Approved Acetaminophen increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [39]
Doxorubicin DMVP5YE Approved Doxorubicin increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [40]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [41]
Cisplatin DMRHGI9 Approved Cisplatin increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [42]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [43]
Arsenic DMTL2Y1 Approved Arsenic increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [44]
Quercetin DM3NC4M Approved Quercetin increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [45]
Temozolomide DMKECZD Approved Temozolomide increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [46]
Arsenic trioxide DM61TA4 Approved Arsenic trioxide increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [47]
Hydrogen peroxide DM1NG5W Approved Hydrogen peroxide increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [48]
Vorinostat DMWMPD4 Approved Vorinostat increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [36]
Triclosan DMZUR4N Approved Triclosan decreases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [49]
Methotrexate DM2TEOL Approved Methotrexate increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [50]
Phenobarbital DMXZOCG Approved Phenobarbital affects the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [52]
Demecolcine DMCZQGK Approved Demecolcine increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [53]
Niclosamide DMJAGXQ Approved Niclosamide increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [54]
Ethanol DMDRQZU Approved Ethanol increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [56]
Paclitaxel DMLB81S Approved Paclitaxel increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [57]
Sodium phenylbutyrate DMXLBCQ Approved Sodium phenylbutyrate decreases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [60]
Imatinib DM7RJXL Approved Imatinib increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [61]
Nefazodone DM4ZS8M Approved Nefazodone increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [63]
Atazanavir DMSYRBX Approved Atazanavir increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [63]
Trovafloxacin DM6AN32 Approved Trovafloxacin increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [67]
Nelfinavir mesylate DMFX6G8 Approved Nelfinavir mesylate increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [68]
Amsacrine DMZKYIV Approved Amsacrine increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [69]
Levofloxacin DMS60RB Approved Levofloxacin increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [67]
AZD5363 DM9SKW8 Approved AZD5363 increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [71]
Naftopidil DMQ8R4E Approved Naftopidil affects the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [72]
Urethane DM7NSI0 Phase 4 Urethane increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [73]
SNDX-275 DMH7W9X Phase 3 SNDX-275 increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [74]
Resveratrol DM3RWXL Phase 3 Resveratrol increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [75]
Epigallocatechin gallate DMCGWBJ Phase 3 Epigallocatechin gallate increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [76]
Curcumin DMQPH29 Phase 3 Curcumin increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [77]
Fenretinide DMRD5SP Phase 3 Fenretinide increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [78]
Chloroquine DMSI5CB Phase 3 Trial Chloroquine increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [56]
Triptolide DMCMDVR Phase 3 Triptolide increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [79]
AZD4547 DM3827C Phase 2/3 AZD4547 affects the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [71]
Belinostat DM6OC53 Phase 2 Belinostat increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [81]
phorbol 12-myristate 13-acetate DMJWD62 Phase 2 phorbol 12-myristate 13-acetate increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [82]
ANW-32821 DMMJOZD Phase 2 ANW-32821 increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [83]
Azd2014 DMOEARH Phase 2 Azd2014 increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [71]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [85]
Leflunomide DMR8ONJ Phase 1 Trial Leflunomide increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [86]
Tetrandrine DMAOJBX Phase 1 Tetrandrine increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [88]
BETULINIC ACID DMBUI2A Phase 1 BETULINIC ACID increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [89]
AZD8186 DMWYF1H Phase 1 AZD8186 affects the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [71]
MG-132 DMKA2YS Preclinical MG-132 increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [91]
EHT-1864 DMYAMP5 Terminated EHT-1864 increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [92]
Bisphenol A DM2ZLD7 Investigative Bisphenol A increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [93]
Trichostatin A DM9C8NX Investigative Trichostatin A increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [81]
Formaldehyde DM7Q6M0 Investigative Formaldehyde increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [53]
Coumestrol DM40TBU Investigative Coumestrol decreases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [94]
Sulforaphane DMQY3L0 Investigative Sulforaphane increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [95]
chloropicrin DMSGBQA Investigative chloropicrin increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [96]
Deguelin DMXT7WG Investigative Deguelin increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [97]
3R14S-OCHRATOXIN A DM2KEW6 Investigative 3R14S-OCHRATOXIN A increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [98]
Paraquat DMR8O3X Investigative Paraquat increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [99]
D-glucose DMMG2TO Investigative D-glucose increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [100]
Rapamycin Immunosuppressant Drug DM678IB Investigative Rapamycin Immunosuppressant Drug increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [57]
U0126 DM31OGF Investigative U0126 decreases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [100]
Cordycepin DM72Y01 Investigative Cordycepin affects the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [102]
Apigenin DMI3491 Investigative Apigenin increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [103]
OLEANOLIC_ACID DMWDMJ3 Investigative OLEANOLIC_ACID increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [105]
Buthionine sulfoximine DMJ46CB Investigative Buthionine sulfoximine increases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [100]
2-APB DM9AKVR Investigative 2-APB decreases the expression of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [110]
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⏷ Show the Full List of 68 Drug(s)
5 Drug(s) Affected the Protein Interaction/Cellular Processes of This DOT
Drug Name Drug ID Highest Status Interaction REF
Marinol DM70IK5 Approved Marinol increases the degradation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [51]
PMID28870136-Compound-52 DMFDERP Patented PMID28870136-Compound-52 increases the cleavage of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [90]
PF-1913539 DMXEU14 Discontinued in Phase 3 PF-1913539 increases the cleavage of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [90]
Bafilomycin A1 DMUNK59 Investigative Bafilomycin A1 increases the cleavage of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [106]
G15 DMMEC9D Investigative G15 affects the localization of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [109]
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15 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Hydroquinone DM6AVR4 Approved Hydroquinone increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [55]
Clozapine DMFC71L Approved Clozapine increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [58]
Sertraline DM0FB1J Approved Sertraline increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [62]
Artesunate DMR27C8 Approved Artesunate increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [64]
Sevoflurane DMC9O43 Approved Sevoflurane increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [65]
2-deoxyglucose DMIAHVU Approved 2-deoxyglucose increases the prenylation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [66]
Miconazole DMPMYE8 Approved Miconazole increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [70]
Amiodarone DMUTEX3 Phase 2/3 Trial Amiodarone increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [80]
Ym155 DM5Q1W4 Phase 2 Ym155 increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [84]
LY294002 DMY1AFS Phase 1 LY294002 increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [87]
E-64D DMCVXBE Preclinical E-64D increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [62]
acrolein DMAMCSR Investigative acrolein increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [101]
Dorsomorphin DMKYXJW Investigative Dorsomorphin decreases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [104]
ABBV-744 DMTEA9C Investigative ABBV-744 increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [107]
BUTEIN DM8E54P Investigative BUTEIN increases the lipidation of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [108]
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⏷ Show the Full List of 15 Drug(s)
1 Drug(s) Affected the Biochemical Pathways of This DOT
Drug Name Drug ID Highest Status Interaction REF
Rifampicin DM5DSFZ Approved Rifampicin decreases the metabolism of Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B). [59]
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