Molecular Interaction Atlas (MIA) |
|
Indication(s) of ARRY-162 |
Disease Entry |
ICD 11 |
Status |
REF |
Melanoma |
2C30
|
Approved |
[2] |
|
|
ARRY-162 Interacts with 2 DTT Molecule(s)
DTT Name |
DTT ID |
UniProt ID |
Mode of Action |
REF |
MAPK/ERK kinase kinase (MAP3K)
|
TTROQ37
|
NOUNIPROTAC
|
Modulator
|
[5] |
ERK activator kinase (MEK)
|
TTZCRP3
|
NOUNIPROTAC
|
Inhibitor
|
[2] |
------------------------------------------------------------------------------------ |
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ARRY-162 Interacts with 2 DTP Molecule(s)
DTP Name |
DTP ID |
UniProt ID |
Mode of Action |
REF |
P-glycoprotein 1 (ABCB1)
|
DTUGYRD
|
MDR1_HUMAN
|
Substrate
|
[6] |
Breast cancer resistance protein (ABCG2)
|
DTI7UX6
|
ABCG2_HUMAN
|
Substrate
|
[6] |
------------------------------------------------------------------------------------ |
|
|
|
|
|
ARRY-162 Interacts with 2 DME Molecule(s)
DME Name |
DME ID |
UniProt ID |
Mode of Action |
REF |
Cytochrome P450 1A2 (CYP1A2)
|
DEJGDUW
|
CP1A2_HUMAN
|
Metabolism
|
[7] |
UDP-glucuronosyltransferase 1A1 (UGT1A1)
|
DEYGVN4
|
UD11_HUMAN
|
Metabolism
|
[8] |
------------------------------------------------------------------------------------ |
|
|
|
|
|
Indication(s) of Brigatinib |
Disease Entry |
ICD 11 |
Status |
REF |
Anaplastic large cell lymphoma |
2A90.A
|
Approved |
[3] |
Non-small-cell lung cancer |
2C25.Y
|
Approved |
[4] |
|
|
Brigatinib Interacts with 1 DTT Molecule(s)
DTT Name |
DTT ID |
UniProt ID |
Mode of Action |
REF |
ALK tyrosine kinase receptor (ALK)
|
TTPMQSO
|
ALK_HUMAN
|
Inhibitor
|
[3] |
------------------------------------------------------------------------------------ |
|
|
|
|
|
Brigatinib Interacts with 2 DTP Molecule(s)
DTP Name |
DTP ID |
UniProt ID |
Mode of Action |
REF |
Breast cancer resistance protein (ABCG2)
|
DTI7UX6
|
ABCG2_HUMAN
|
Substrate
|
[9] |
ATP-binding cassette sub-family B member 5 (ABCB5)
|
DTKVEXO
|
ABCB5_HUMAN
|
Substrate
|
[9] |
------------------------------------------------------------------------------------ |
|
|
|
|
|
Brigatinib Interacts with 1 DME Molecule(s)
DME Name |
DME ID |
UniProt ID |
Mode of Action |
REF |
Cytochrome P450 2C8 (CYP2C8)
|
DES5XRU
|
CP2C8_HUMAN
|
Metabolism
|
[10] |
------------------------------------------------------------------------------------ |
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