Details of the Drug Combinations

General Information of This Drug (ID: DM6A0X7)

• Drug Name: Pravastatin (DM6A0X7)
• Synonyms: Eptastatin; Oliprevin; Pravastatina; Pravastatine; Pravastatinum; Pravator; Vasten; Pravastatin Sodium Salt; Pravastatina [Spanish]; Pravastatine [French]; Pravastatinum [Latin]; KS-5015; Pravachol (TN); Pravastatin (INN); Pravastatin [INN:BAN]; Pravastatin tert-Octylamine Salt; Pravator (TN); RMS-431; Selektine (TN); SQ-31,000; (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid; (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid; 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha))-1-Naphthaleneheptanoic acid

Indication

Adult acute monocytic leukemia; ICD 11: N.A.; Status: Approved [1]; Arteriosclerosis; ICD 11: BD40; Status: Approved [1]; Hypercholesterolaemia; ICD 11: 5C80.0; Status: Approved [2]; Hyperlipidemia, familial combined, LPL related; ICD 11: N.A.; Status: Approved [1]; Hypertriglyceridemia; ICD 11: 5C80.1; Status: Approved [1]; Stroke; ICD 11: 8B20; Status: Investigative [1]

• Therapeutic Class: Anticholesteremic Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

3 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Pravastatin + Panobinostat	DCK2LD2	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Pravastatin + Marizomib	DCUA7QQ	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Pravastatin + Idarubicin	DCEW84I	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]

13 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AKB-6548 + Pravastatin	DC38281	AKB-6548	Drug Interaction Potentiation	[4]
Pravastatin + Valsartan	DC4W0ED	Valsartan	Hypertension	[5]
Pravastatin + Dalcetrapib	DCLREJB	Dalcetrapib	Dyslipidemia	[6]
Pravastatin + Rosuvastatin	DCT4VKM	Rosuvastatin	Type IIa and IIb Hypercholesterolaemia	[7]
Pravastatin + [3H]estrone-3-sulphate	DC6H7OB	[3H]estrone-3-sulphate	Hyperlipidaemia	[8]
Pravastatin + Atorvastatin	DC2YZPU	Atorvastatin	Rheumatoid Arthritis	[9]
Pravastatin + RG6046	DCB04DR	RG6046	Breast Cancer	[10]
Pravastatin + Bortezomib	DCOW9GD	Bortezomib	Leukemia	[11]
Pravastatin + CATECHIN	DCXHG7P	CATECHIN	Dyslipidemias	[12]
Lisinopril + Pravastatin	DCAQXPO	Lisinopril	Breast Carcinoma	[13]
Pravastatin + SODIUM CITRATE	DCJIS89	SODIUM CITRATE	Autosomal Dominant Polycystic Kidney Disease	[14]
Pravastatin + Fosinopril	DCEYFCZ	Fosinopril	Microalbuminuria	[15]
Pravastatin + Pravastatin	DC1ZOKP	Pravastatin	HIV Infections	[16]

References

• [1] Pravastatin FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2953).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT03801733) Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin
• [5] ClinicalTrials.gov (NCT00738972) Left Ventricular Hypertrophy Reduction With Statins in Hypertensives Patients (MK0653A-168)
• [6] ClinicalTrials.gov (NCT00697203) A Study to Assess the Effect of RO4607381 in Patients With Relatively Low Levels of High Density Lipoprotein-Cholesterol (HDL-C)
• [7] ClinicalTrials.gov (NCT00631189) Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic Patients
• [8] Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2(7):517-26.
• [9] ClinicalTrials.gov (NCT04608344) Study to Evaluate Organic Anion Transporting Polypeptide (OATP) Transporter-Mediated Drug-Drug Interactions Between Filgotinib and Statins as Probe Drugs in Healthy Participants
• [10] ClinicalTrials.gov (NCT02621957) Effect of GDC-0810 on the Pharmacokinetics of Pravastatin in Healthy Female Subjects of Non-Childbearing Potential
• [11] ClinicalTrials.gov (NCT02484261) Monitoring and Treatment of Relapsed Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation in Children
• [12] ClinicalTrials.gov (NCT02431013) Cilostazol-Simvastatin Drug Interaction Study
• [13] ClinicalTrials.gov (NCT04190433) Autophagy Activation for the Alleviation of Cardiomyopathy Symptoms After Anthracycline Treatment, ATACAR Trial
• [14] ClinicalTrials.gov (NCT04284657) Pravastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease
• [15] ClinicalTrials.gov (NCT03073018) Prevention of Renal and Vascular Endstage Disease Intervention Trial
• [16] ClinicalTrials.gov (NCT00630734) Genetic Predictors of Variability in the Drug-drug Interaction Between Darunavir/Ritonavir and Pravastatin