Details of the Drug Combinations

General Information of This Drug (ID: DM7L8SG)

Drug Name
AZD8055   DM7L8SG
Synonyms
AZD8055; 1009298-09-2; AZD-8055; AZD 8055; [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol; (5-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol; UNII-970JJ37FPW; 970JJ37FPW; CHEMBL1801204; AK109550; (5-(2,4-Bis((S)-3-methylmorpholino)pyrido-[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol; (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1/2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

48 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + AZD8055 DC9XF10 (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + AZD8055 DCBP1UZ ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
ABT-263 + AZD8055 DC9LXD0 ABT-263 Glioblastoma (Cell Line: JHH-136) [3]
AS602868 + AZD8055 DCCA682 AS602868 Glioblastoma (Cell Line: JHH-136) [2]
AZD8055 + Ruxolitinib DCHLSIF Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
AZD8055 + Ruxolitinib DCL1DI2 Ruxolitinib Hodgkin lymphoma (Cell Line: HDLM-2) [2]
AZD8055 + Ruxolitinib DCU160P Ruxolitinib T-cell leukemia/lymphoma (Cell Line: ED-40515) [2]
AZD8055 + Trametinib DCAJRS9 Trametinib Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
AZD8055 + Trametinib DCZQ41N Trametinib Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
AZD8055 + Trametinib DCL1OQV Trametinib Glioblastoma (Cell Line: JHH-136) [2]
AZD8055 + Cladribine DCR95QJ Cladribine Glioblastoma (Cell Line: JHH-136) [2]
AZD8055 + JQ1 DC0I3UN JQ1 Ewing sarcoma (Cell Line: TC-71) [2]
AZD8055 + Carfilzomib DC090AK Carfilzomib Ewing sarcoma (Cell Line: TC-71) [2]
AZD8055 + Panobinostat DCTVAIT Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
AZD8055 + Fomepizole DC4TGRK Fomepizole Ewing sarcoma (Cell Line: TC-71) [2]
AZD8055 + Everolimus DC3X8J9 Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
AZD8055 + TAK-733 DCWC3E1 TAK-733 Glioblastoma (Cell Line: JHH-136) [2]
AZD8055 + Docetaxel DCCPZWL Docetaxel Ewing sarcoma (Cell Line: TC-71) [2]
AZD8055 + THAPSIGARGIN DCCLX1Y THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [2]
AZD8055 + GDC-0980/RG7422 DCHN5V2 GDC-0980/RG7422 Glioblastoma (Cell Line: JHH-136) [2]
AZD8055 + Cotellic DCQFZ45 Cotellic Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
AZD8055 + Cotellic DCDY037 Cotellic Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
AZD8055 + Cotellic DCHQM09 Cotellic Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
AZD8055 + PHA-739358 DCUWCSH PHA-739358 Ewing sarcoma (Cell Line: TC-71) [2]
AZD8055 + Vincristine DC0X3B5 Vincristine Ewing sarcoma (Cell Line: TC-71) [2]
AZD8055 + Pelitinib DCC2IIB Pelitinib Glioblastoma (Cell Line: JHH-136) [2]
AZD8055 + GSK2126458 DCQB2T5 GSK2126458 Glioblastoma (Cell Line: JHH-136) [2]
AZD8055 + Obatoclax DC2RQ39 Obatoclax Glioblastoma (Cell Line: JHH-136) [2]
AZD8055 + Podofilox DCHG9OK Podofilox Glioblastoma (Cell Line: JHH-136) [2]
AZD8055 + Romidepsin DCJSR1I Romidepsin Ewing sarcoma (Cell Line: TC-71) [2]
AZD8055 + Mitotane DC5E6GT Mitotane Ewing sarcoma (Cell Line: TC-71) [2]
Bardoxolone methyl + AZD8055 DC0ZXXA Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
BN-2629 + AZD8055 DCQ5ZV7 BN-2629 Ewing sarcoma (Cell Line: TC-71) [2]
CA4P + AZD8055 DCC17X1 CA4P Glioblastoma (Cell Line: JHH-136) [2]
Cabozantinib + AZD8055 DCYH5NW Cabozantinib Ewing sarcoma (Cell Line: TC-71) [2]
Cantharidin + AZD8055 DCBI5UW Cantharidin Ewing sarcoma (Cell Line: TC-71) [2]
Carfilzomib + AZD8055 DCS7COI Carfilzomib Ewing sarcoma (Cell Line: TC-71) [2]
Cycloheximide + AZD8055 DCP79JG Cycloheximide Ewing sarcoma (Cell Line: TC-71) [2]
Efaproxyn + AZD8055 DC4VVI5 Efaproxyn Ewing sarcoma (Cell Line: TC-71) [2]
Everolimus + AZD8055 DC249EH Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Fenretinide + AZD8055 DCOIF0N Fenretinide Glioblastoma (Cell Line: JHH-136) [2]
LY2523355 + AZD8055 DC1WOPI LY2523355 Ewing sarcoma (Cell Line: TC-71) [2]
LY2874455 + AZD8055 DCL8ZEO LY2874455 Ewing sarcoma (Cell Line: TC-71) [2]
MK-1775 + AZD8055 DC16FFF MK-1775 Ewing sarcoma (Cell Line: TC-71) [2]
MK-2206 + AZD8055 DCBUA3G MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
Steroid derivative 1 + AZD8055 DC1G572 Steroid derivative 1 Ewing sarcoma (Cell Line: TC-71) [2]
Topetecan + AZD8055 DCBY6C9 Topetecan Glioblastoma (Cell Line: JHH-136) [2]
Verteporfin + AZD8055 DCXFRLV Verteporfin Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 48 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7714).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.