General Information of This Drug (ID: DM93VBZ)

Drug Name
LY2835219   DM93VBZ
Synonyms Abemaciclib; 1231929-97-7; Verzenio; LY-2835219; UNII-60UAB198HK; LY2835219 (free base);
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Solid tumour/cancer 2A00-2F9Z Phase 3 [2]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

13 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Bafilomycin A1 + LY2835219 DCUI17H Bafilomycin A1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Erlotinib + LY2835219 DC94UEB Erlotinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
LY2835219 + Crizotinib DCXUMGU Crizotinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
LY2835219 + Panobinostat DCPHBQL Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
LY2835219 + Selumetinib DCGNNLQ Selumetinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
LY2835219 + Vincristine DCEG21B Vincristine Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
LY2835219 + Doxorubicin DC0Y4RQ Doxorubicin Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
MK-1775 + LY2835219 DC6JONG MK-1775 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
PD-0325901 + LY2835219 DCW2KK0 PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Pyrazinamide + LY2835219 DCETMM9 Pyrazinamide Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Ribavirin-TP + LY2835219 DCPVTPZ Ribavirin-TP Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Teriflunomide + LY2835219 DCR1DUW Teriflunomide Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
THAPSIGARGIN + LY2835219 DCTD8U8 THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
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⏷ Show the Full List of 13 DrugCom(s)
38 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
ABIRATERONE + LY2835219 DCLEBJ0 ABIRATERONE Advanced Cancer [4]
Clarithromycin + LY2835219 DC6IN7U Clarithromycin Neoplasm [5]
Everolimus + LY2835219 DCHRH0E Everolimus Breast Neoplasms [6]
Fulvestrant + LY2835219 DC0DGRR Fulvestrant Advanced Cancer [7]
Gemcitabine + LY2835219 DCWQDSF Gemcitabine Carcinoma, Non-small Cell Lung [8]
LY2835219 + LY2835219 DCL0TJ2 LY2835219 HR+/HER2- Breast Cancer [9]
LY2835219 + Temozolomide DCNZB8A Temozolomide Relapsed Solid Tumor [10]
LY2835219 + Hydroxychloroquine DC2D0P2 Hydroxychloroquine Solid Tumor [11]
LY2835219 + Temozolomide DC2E1ZE Temozolomide Relapsed Solid Tumor [10]
LY2835219 + Sunitinib DC39RDV Sunitinib Renal Cell Carcinoma Metastatic [12]
LY2835219 + LY3039478 DC3RV09 LY3039478 Solid Tumor [13]
LY2835219 + Bicalutamide DC9WWHD Bicalutamide Breast Cancer [14]
LY2835219 + Anastrozole DCAP4QX Anastrozole Breast Neoplasms [6]
LY2835219 + Letrozole DCBRVQY Letrozole Breast Neoplasms [6]
LY2835219 + MK-4827 DCCFYMI MK-4827 Anatomic Stage I Breast Cancer AJCC v8 [15]
LY2835219 + Exemestane DCUZLDF Exemestane Breast Neoplasms [6]
LY2835219 + Pemetrexed DCZXWWR Pemetrexed Carcinoma, Non-small Cell Lung [8]
Olaparib + LY2835219 DC2UJA3 Olaparib Recurrent Ovarian High Grade Serous Adenocarcinoma [16]
RAD-1901 + LY2835219 DCXY87G RAD-1901 Breast Cancer [17]
RAD-1901 + LY2835219 DC2AU8U RAD-1901 Breast Neoplasms [18]
RAD-1901 + LY2835219 DCLRU53 RAD-1901 Breast Cancer [19]
Ruxolitinib + LY2835219 DCXVBR5 Ruxolitinib Myelofibrosis Due to and Following Polycythemia Vera [20]
Degarelix + LY2835219 DCNMY6P Degarelix Male Breast Cancer [21]
Fulvestrant + LY2835219 DCR3Q0K Fulvestrant Anatomic Stage IV Breast Cancer AJCC v8 [22]
Fulvestrant + LY2835219 DC9JUZ2 Fulvestrant Breast Cancer [23]
Fulvestrant + LY2835219 DCJSKSZ Fulvestrant Breast Cancer Metastatic [24]
LY2835219 + Anastrozole DC24QBY Anastrozole Breast Cancer [25]
LY2835219 + Letrozole DC3V2G3 Letrozole Recurrent Endometrial Carcinoma [26]
LY2835219 + Gonadorelin DC5BMCN Gonadorelin Early Breast Cancer [27]
LY2835219 + Metformin DCEM6V9 Metformin Endometrial Cancer [28]
LY2835219 + Temozolomide DCEQDY1 Temozolomide Neoplasms [29]
LY2835219 + Temozolomide DCNVPW7 Temozolomide Sarcoma, Ewing [30]
LY2835219 + Hydroxychloroquine DC7L5M5 Hydroxychloroquine Breast Cancer [31]
LY2835219 + Osimertinib DC8DL1L Osimertinib Lung Cancer [32]
LY2835219 + Tamoxifen DCAF96A Tamoxifen Male Breast Cancer [21]
LY2835219 + Letrozole DCPBCJQ Letrozole Endometrial Cancer [28]
Fulvestrant + LY2835219 DCVYG39 Fulvestrant Breast Cancer [33]
LY2835219 + Letrozole DCCPSYD Letrozole Breast Cancer [34]
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⏷ Show the Full List of 38 DrugCom(s)

References

1 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7382).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT04071262) A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Therapies in Japanese Participants With Advanced Cancer
5 ClinicalTrials.gov (NCT02117648) A Study of LY2835219 in Participants With Cancer
6 ClinicalTrials.gov (NCT02057133) A Study of LY2835219 (Abemaciclib) in Combination With Therapies for Breast Cancer That Has Spread
7 ClinicalTrials.gov (NCT01394016) A Phase 1 Study of LY2835219 In Participants With Advanced Cancer
8 ClinicalTrials.gov (NCT02079636) A Study of Abemaciclib (LY2835219) in Combination With Another Anti-cancer Drug in Participants With Lung Cancer (NSCLC)
9 ClinicalTrials.gov (NCT05789771) Abemaciclib for the Treatment of Luminal Metastatic breAst caNcer in the Real-life Clinical pracTice in Russia.
10 ClinicalTrials.gov (NCT04238819) A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma
11 ClinicalTrials.gov (NCT04316169) Hydroxychloroquine, Abemaciclib and Endocrine Therapy in Hormone Receptor Positive (HR+)/Her 2 Negative Breast Cancer
12 ClinicalTrials.gov (NCT03905889) A Study of Abemaciclib in Combination With Sunitinib in Metastatic Renal Cell Carcinoma
13 ClinicalTrials.gov (NCT02784795) A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health.
14 ClinicalTrials.gov (NCT05095207) Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
15 ClinicalTrials.gov (NCT04481113) Abemaciclib and Niraparib Before Surgery for the Treatment of Hormone Receptor Positive HER2 Negative Breast Cancer
16 ClinicalTrials.gov (NCT04633239) Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer
17 ClinicalTrials.gov (NCT05563220) Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Patients With Metastatic Breast Cancer
18 ClinicalTrials.gov (NCT05386108) Study of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to HR+/HER2- Breast Cancer
19 ClinicalTrials.gov (NCT04791384) Phase Ib/II Trial of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to HR+/Her2- Breast Cancer
20 ClinicalTrials.gov (NCT05714072) A Study of Ruxolitinib in Combination With Abemaciclib for the Treatment of Myelofibrosis
21 ClinicalTrials.gov (NCT05501704) ETHAN - ET for Male BC
22 ClinicalTrials.gov (NCT04256941) Aromatase Inhibitor Therapy With or Without Fulvestrant for the Treatment of HR Positive Metastatic Breast Cancer With an ERS1 Activating Mutation, the INTERACT Study
23 ClinicalTrials.gov (NCT05524584) Anastrazole, Fulvestrant & Abemaciclib for HR+HER2- Metastatic Breast Cancer
24 ClinicalTrials.gov (NCT04603183) ABemaciclib, ET paclItaxel in aGgressive HR+/HER2- MBC trIaL
25 ClinicalTrials.gov (NCT02441946) A Neoadjuvant Study of Abemaciclib (LY2835219) in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast Cancer
26 ClinicalTrials.gov (NCT04469764) Abemaciclib for the Treatment of Recurrent Ovarian or Endometrial Cancer
27 ClinicalTrials.gov (NCT04293393) Neoadjuvant Study Chemotherapy vs Letrozole + Abemaciclib in HR+/HER2- High/Intermediate Risk Breast Cancer Patients
28 ClinicalTrials.gov (NCT03675893) Abemaciclib + Letrozole +/- Metformin in Recurrent or Persistent Endometrial Cancer
29 ClinicalTrials.gov (NCT05999994) A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
30 ClinicalTrials.gov (NCT05440786) CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma
31 ClinicalTrials.gov (NCT04523857) ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer
32 ClinicalTrials.gov (NCT04545710) Osimertinib and Abemaciclib in EGFR Mutant Non-Small Cell Lung Cancer After Osimertinib Resistance
33 ClinicalTrials.gov (NCT02763566) A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer
34 ClinicalTrials.gov (NCT02246621) A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer