Details of the Drug Combinations

General Information of This Drug (ID: DM9R0ZL)

Drug Name
CA4P   DM9R0ZL
Synonyms
Fosbretabulin disodium; 168555-66-6; Combretastatin A4 disodium phosphate; CA4DP; Fosbretabulin (disodium); Zybrestat; UNII-702RHR475O; Combretastatin A4 Phosphate Disodium Salt; Fosbretabulin disodium [USAN]; 702RHR475O; Combretastatin A-4 phosphate; Fosbretabulin disodium (USAN); CHEMBL289351; Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium; AC1OCF9S; Fosbretabulin Disodium Salt; CA-4P; CA 4P; SCHEMBL321426; C18H19O8P.2Na; MolPort-006-823-175; ACT03122; 3559AH; s7204; AKOS027327946; BCP9000542; CS-1484; NSC-752293; Fosbr
Indication
Disease Entry ICD 11 Status REF
Neuroendocrine cancer 2B72.1 Phase 2 [1]
Ovarian cancer 2C73 Phase 2 [1]
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

48 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Abexinostat + CA4P DCA47F5 Abexinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ABT-263 + CA4P DC5V4CT ABT-263 Glioblastoma (Cell Line: JHH-136) [3]
Afatinib + CA4P DCD6E4L Afatinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
BMS-754807 + CA4P DC3Z6AN BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
CA4P + Gefitinib DCGV69I Gefitinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + GDC0941 DCKIFTU GDC0941 Glioblastoma (Cell Line: JHH-136) [2]
CA4P + Ruxolitinib DC3Z552 Ruxolitinib T-cell leukemia/lymphoma (Cell Line: ED-40515) [2]
CA4P + PD-0325901 DCTPSTS PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Trametinib DCC4G7O Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Trametinib DCKM6F1 Trametinib Glioblastoma (Cell Line: JHH-136) [2]
CA4P + Cladribine DCPK56Z Cladribine Glioblastoma (Cell Line: JHH-136) [2]
CA4P + JQ1 DCO26JX JQ1 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + JQ1 DCU06XJ JQ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
CA4P + Panobinostat DCJR0ZO Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
CA4P + Panobinostat DCHEZJK Panobinostat Glioblastoma (Cell Line: JHH-136) [2]
CA4P + Ym155 DCAJJ87 Ym155 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + RTB101 DCRLOPH RTB101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Fostamatinib DCIANR9 Fostamatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + AZD8055 DCC17X1 AZD8055 Glioblastoma (Cell Line: JHH-136) [2]
CA4P + Cantharidin DCV9U6W Cantharidin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Evacetrapib DCR8V32 Evacetrapib Glioblastoma (Cell Line: JHH-136) [2]
CA4P + SCH 727965 DC68EX1 SCH 727965 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Daporinad DC0ML31 Daporinad Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + THAPSIGARGIN DCOGAGW THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + SNS-032 DCPGWTM SNS-032 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + GDC-0980/RG7422 DC35FTU GDC-0980/RG7422 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + GDC-0980/RG7422 DC3H74G GDC-0980/RG7422 Glioblastoma (Cell Line: JHH-136) [2]
CA4P + Mitomycin DCSUFVV Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
CA4P + SNDX-275 DCNCZQN SNDX-275 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + OSI-027 DCLUSNN OSI-027 Glioblastoma (Cell Line: JHH-136) [2]
CA4P + Flavopiridol DCS4BQR Flavopiridol Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + AS602868 DCAH5I9 AS602868 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Tamoxifen DC8JBGF Tamoxifen Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Ciclopirox DCRJAVG Ciclopirox Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Mebendazole DCHSO8B Mebendazole Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Bardoxolone methyl DC3XF8I Bardoxolone methyl Glioblastoma (Cell Line: JHH-136) [2]
CA4P + BIIB-021 DCJRX1D BIIB-021 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Obatoclax DCW09TM Obatoclax Glioblastoma (Cell Line: JHH-136) [2]
CA4P + BMS-754807 DC26UV6 BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + PF-04691502 DCI5SJW PF-04691502 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Dasatinib DCIOTLP Dasatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + Ruxolitinib DC9LTBX Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
Marimastat + CA4P DCZTE63 Marimastat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Mebendazole + CA4P DCBQVJ6 Mebendazole Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Mebendazole + CA4P DCHTZ61 Mebendazole Glioblastoma (Cell Line: JHH-136) [2]
MK-2206 + CA4P DC1ZTB8 MK-2206 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + CA4P DCNI4FE THZ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Trametinib + CA4P DCW6XU0 Trametinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
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⏷ Show the Full List of 48 DrugCom(s)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.