Details of the Drug Combinations

General Information of This Drug (ID: DM9S1EA)

Drug Name
Pepstatin   DM9S1EA
Synonyms
AC1NUZ3J; L-Valinamide, N-(3-methyl-1-oxobutyl)-L-valyl-N-(4-((2-((1-(2-carboxy-1-hydroxyethyl)-3-methylbutyl)amino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl)-, (1S-(1R*,2R*,4(R*(R*(R*)))))-; N-Isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-gamma-aminoheptanoyl-L-alanyl-3-hydroxy-6-methyl-gamma-aminoheptanoic acid
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Terminated [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

103 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Allopurinol + Pepstatin DCWTSB2 Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aprepitant + Pepstatin DC3KG1W Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + Pepstatin DC38HUR Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Armodafinil + Pepstatin DCDNT5O Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atenolol + Pepstatin DCJH4LT Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Pepstatin DCW1HWK BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Pepstatin DCAM9DF Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bosentan + Pepstatin DCPCZ53 Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Buspirone + Pepstatin DCMCWI4 Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Carglumic acid + Pepstatin DCN8YF9 Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Pepstatin DCHDT9I Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + Pepstatin DC93YHT Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cinacalcet + Pepstatin DC7K8QS Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cisatracurium + Pepstatin DC6C1QI Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clindamycin + Pepstatin DCKCGE2 Clindamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Pepstatin DCM7UM5 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Darunavir + Pepstatin DCFW05A Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dronedarone + Pepstatin DCS81Z2 Dronedarone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Eptifibatide + Pepstatin DCOAK4K Eptifibatide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethinyl estradiol + Pepstatin DC3LRDX Ethinyl estradiol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gefitinib + Pepstatin DC5IFN1 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Pepstatin DC02QCK GYKI-52466 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Pepstatin DCWWO7F Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Pepstatin DCNNTKC Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Kanamycin + Pepstatin DC6O8IN Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + Pepstatin DCO29TS Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lumefantrine + Pepstatin DCO1L3O Lumefantrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methotrexate + Pepstatin DCG65PG Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methoxsalen + Pepstatin DC81QI7 Methoxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Miglustat + Pepstatin DCJR1P3 Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Pepstatin DCZ5W32 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nabilone + Pepstatin DCORKXC Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Niclosamide + Pepstatin DCB6S2L Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitrosoglutathione + Pepstatin DC09AM7 Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Olanzapine + Pepstatin DCFOV9N Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Oxyphenbutazone + Pepstatin DCHIH05 Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pargyline + Pepstatin DCSM421 Pargyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Paromomycin + Pepstatin DCSRGRU Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Ribavirin-TP DCNQZIA Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Citalopram DC8WXPN Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Epinephrine DCJLFU2 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + PMID28460551-Compound-2 DCYQVV7 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + LIAROZOLE DCQBWV7 LIAROZOLE Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Anamorelin DCTMWGB Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Fomepizole DCSU7BB Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Ramelteon DC3J0SN Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Tranexamic acid DCZQQB9 Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + BHV-0223 DCLXPI6 BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Metyrosine DC4AOIJ Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Cycloguanil DC5XKRQ Cycloguanil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + SCH 727965 DCIZHTM SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Amodiaquine DC7PY05 Amodiaquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Itraconazole DC84F4M Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Emetine DCHRJ62 Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Phenprocoumon DCIUZKM Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + JZL195 DC7ZMSV JZL195 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + VR-776 DCNCIGP VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + PFK-158 DCTNSAI PFK-158 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Eflornithine DC3MHCM Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Trifluoperazine DC7AQVT Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Oseltamivir DC2POZL Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Diazoxide DC9IKPX Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Benserazide DC3R47O Benserazide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Idarubicin DCQKHHW Idarubicin Glioblastoma? (Cell Line: T98G) [2]
Pepstatin + Methocarbamol DCE10AG Methocarbamol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + BRL-15572 DCAKE20 BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Probenecid DCIQ53J Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Pramipexole DC5JEP4 Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Methylene blue DCDOGGV Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Tropisetron DCLKMFO Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Acamprosate DC5F2OZ Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Mesalazine DC7N7HD Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Miconazole DC4LZXY Miconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Maprotiline DCSKEH3 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Acetohexamide DCS11HV Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Leflunomide DCN6AYN Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Novobiocin DCI33DT Novobiocin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Asenapine DC9IJ5G Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Quinine DCX1A1D Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Endoxifen DC9ISLB Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Mycophenolic acid DCCSPEC Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Pizotyline DCZO0BU Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Doxorubicin DCQ5H29 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Olmesartan medoxomil DCNAZUH Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Estramustine DCY3WQC Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Lithium Citrate DCSRQPH Lithium Citrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Metaxalone DCJ2X6C Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + ML323 DCRGWCF ML323 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Aciclovir DC29OI6 Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Acetohydroxamic Acid DCVKMCD Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Tacrolimus DCVECWT Tacrolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + Pepstatin DCBL4OJ Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Rufinamide + Pepstatin DCTDJSO Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sumatriptan + Pepstatin DCMYXSC Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tamoxifen + Pepstatin DCH06RJ Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + Pepstatin DCXHWGA Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terazosin + Pepstatin DCGJ2W8 Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Teriflunomide + Pepstatin DCBJI3V Teriflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testosterone + Pepstatin DCV5PHQ Testosterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tindamax + Pepstatin DCY66O2 Tindamax Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolvaptan + Pepstatin DCF10TK Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + Pepstatin DCGX9FX Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Vinblastine + Pepstatin DCKU227 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004280)
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.